Clinical trials: Breast Cancer, Breast Neoplasms
Metastatic Breast Cancer
Phase I/II Trial of Sorafenib Plus Ixabepilone in HER2-Negative Metastatic Breast Cancer
In this study, patients with metastatic HER2-negative breast cancer will receive treatment with ixabepilone and sorafenib until disease progression or unacceptable toxicity occurs.
- Trial name
- NCT00825734
- Testing
- Sorafenib, Ixabepilone
- Where
- 15 sites in United States
- Volunteers
- 83 people
- Sponsor
- SCRI Development Innovations, LLC
Breast Cancer
A Trial of SHR-1210 (an Anti-PD-1 Antibody) in Combination With Apatinib in Patients With Advanced TNBC
This is a Phase II, Open-labeled, Randomised, Parallel, Non-comparative, Two-arms, Investigator-initiated Clinical Trial of SHR-1210 (Anti-PD-1 Antibody) in Combination With Apatinib (VEGFR2 inhibitor) in Subjects with Advanced…
- Trial name
- NCT03394287
- Testing
- SHR-1210, Apatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
Elevate! : An Elderly Breast Cancer Cohort Study
This study is focused on understanding how the investigators can improve upon breast cancer and health outcomes for older participants with breast cancer.
- Trial name
- NCT03818087
- Testing
- Observational cohort
- Where
- 4 sites in United States
- Volunteers
- 253 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Combination Chemotherapy With or Without Trastuzumab in Treating Patients With Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00295893
- Testing
- cyclophosphamide, docetaxel, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- City of Hope Medical Center
Breast Cancer
Bioequivalency Study of Exemestane 25 mg Tablet Under Fasted Conditions
The objective of this study was to prove the bioequivalence of Exemestane 25 mg tablet under fasted conditions
- Trial name
- NCT01331421
- Testing
- exemestane
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Breast Cancer
Clinical Trial of Trametes Versicolor in Women With Breast Cancer
RATIONALE: Coriolus versicolor mushroom extract may slow the growth of cancer cells and may be an effective treatment for breast cancer.
- Trial name
- NCT00680667
- Testing
- Coriolus versicolor extract
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Breast Cancer, Fatigue
Acupressure for Pain and Opioid Use Among Breast Cancer Patients
This study seeks to determine the feasibility of recruiting and training participants in self-acupressure, for women undergoing primary breast cancer surgery or delayed reconstruction surgery.
- Conditions
- Breast Cancer, Fatigue, Chronic Pain
- Trial name
- AcuPOP (NCT03655600)
- Testing
- Self-administered acupressure
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Breast Cancer
Circulating miRNAs as Biomarkers of Hormone Sensitivity in Breast Cancer
This is a biomedical and prospective study of interventional type. The trial will include 29 patients over a period of 15 months + 24 months of follow up maximum.
- Trial name
- MIRHO (NCT01612871)
- Testing
- Tamoxifen, Letrozole , Anastrozole, Exemestane
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- Institut Claudius Regaud
Breast Neoplasms
Study of Fluorodeoxyglucose (FluGlucoScan) in Patients With Breast Cancer: Correlation With Histologic Findings of Sentinel Node Biopsies and Axillary Dissection
Breast cancer affects many women. One of the places to which it can spread is the lymph glands under the arm. The type of treatment offered to patients often will depend on whether those lymph glands have cancer in them or not.
- Trial name
- NCT00123799
- Testing
- Positron Emission Tomography Imaging
- Where
- Canada
- Volunteers
- 199 people
- Sponsor
- AHS Cancer Control Alberta
Breast Cancer
A Study of GDC-0927 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer
This is an open-label, dose-finding, safety, pharmacokinetics (PK), and evidence-of-activity study of GDC-0927 in postmenopausal women with locally advanced or metastatic Estrogen Receptor Positive (ER+) Human Epidermal Growth…
- Trial name
- NCT02316509
- Testing
- GDC-0927
- Where
- 13 sites in United States, Spain
- Volunteers
- 43 people
- Sponsor
- Genentech, Inc.
PIK3CA Mutation, Solid Tumor, Adult
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
This is an open-label, FIH study designed to evaluate the maximum tolerated dose, recommended Phase 2 dose, safety, tolerability, PK, pharmacodynamics, and preliminary antineoplastic activity of RLY-2608, in advanced solid tumor…
- Conditions
- PIK3CA Mutation, Solid Tumor, Adult, HER2-negative Breast Cancer, Breast Cancer
- Trial name
- NCT05216432
- Testing
- RLY-2608, Fulvestrant, Palbociclib 125mg
- Where
- 37 sites in United States, Australia and 3 more
- Volunteers
- 930 people
- Sponsor
- Relay Therapeutics, Inc.
Breast Cancer
Five Sessions Intervention to Facilitate Adaptation to Breast Cancer
To test the effects of 2 different 5-wk stress management interventions (cognitive behavioral training or relaxation training) vs.
- Trial name
- NCT02103387
- Testing
- Cognitive Behavioral Training, Relaxation Training, Health Education Control
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of Miami
Breast Cancer
Dragon Boat Race Versus Family Unsupervised Training to Improve the Physical Function and Quality of Life in Breast Cancer Patients
Investigators plans to conduct a randomized, open, single center clinical study of Dragon Boat Race versus family unsupervised training to improve the physical function and quality of life in breast cancer patients to compare the…
- Trial name
- NCT07162298
- Testing
- Dragon Boat Training, Home-based Unsupervised Training
- Where
- China
- Volunteers
- 72 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Breast Cancer
Chronic Post Breast Surgery Pain
The purpose of this study is to learn if paravertebral block (PVB) will reduce chronic pain after surgery. Our hypothesis is that chronic pain from breast surgery as a consequence of central sensitization can be prevented by…
- Trial name
- NCT00847067
- Testing
- Paravertebral block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Locally Advanced Breast Cancer, Metastatic Breast Cancer
Efficacy and Safety of Tenalisib (RP6530), in Patients With Locally Advanced or Metastatic Breast Cancer
Phase II, randomized, open-label study, designed to evaluate the preliminary efficacy and safety of tenalisib at two dose levels in 40 patients with locally advanced or metastatic breast cancer.
- Trial name
- NCT05021900
- Testing
- Tenalisib 800mg, Tenalisib 1200mg
- Where
- 3 sites in Georgia
- Volunteers
- 40 people
- Sponsor
- Rhizen Pharmaceuticals SA
Healthy
DDI Study With Multiple-dose LX4211 and Single Dose Rosuvastatin
This study will be conducted as a single-center, open-label, 2-period, single-sequence, drug-drug interaction study to assess the effects of multiple-dose LX4211 400 mg (2 × 200-mg tablets qd × 7 days) on the PK of single-dose…
- Trial name
- NCT02300363
- Testing
- Treatment A (rosuvastatin), Treatment B (LX4211), Treatment C (rosuvastatin + 400 mg LX4211 administered concomitantly)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Primary Breast Cancer, Recurrent/Metastatic Breast Cancer
Breast Cancer Proteomics and Molecular Heterogeneity
Primary objective: The primary objective is to define the proteomic and molecular characteristics of primary and recurrent/ metastatic breast tumours with special focus on the expression of S100 protein and the estrogen receptor…
- Trial name
- NCT01840293
- Where
- 6 sites in Ireland
- Volunteers
- 1,780 people
- Sponsor
- Cancer Trials Ireland
Postmenopausal Osteoporosis
Prevention of Osteoporosis in Breast Cancer Survivors
The purpose of this study is to test whether strength/weight training exercises enhance the effectiveness of calcium, vitamin D, and risedronate for the prevention and treatment of osteoporosis in postmenopausal breast cancer…
- Trial name
- NCT00567606
- Testing
- Strength/Weight Training & Drug/Supplement, Drug/Supplement only
- Where
- 4 sites in United States
- Volunteers
- 249 people
- Sponsor
- University of Nebraska
Male Breast Cancer
Testosterone & Tamoxifen Trial
This is a concise single arm, feasibility study, which will be executed in the University Medical Center Groningen, The Netherlands.
- Trial name
- T&T (NCT05156606)
- Testing
- AndroGel
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- University Medical Center Groningen
Breast Cancer
Paclitaxel Plus Bevacizumab for Older Patients With Breast Cancer
This study will evaluate the efficacy, safety and effect on quality of life of weekly paclitaxel plus bevacizumab as first line treatment in elderly patients (≥ 70 years old) with metastatic breast cancer.
- Trial name
- NCT01120158
- Testing
- Bevacizumab, Paclitaxel
- Where
- 11 sites in Greece
- Volunteers
- 46 people
- Sponsor
- Hellenic Oncology Research Group
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