Clinical trials: Breast Lesion
Metastases to Bone, Metastatic Breast Cancer
Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS Study
Osteolytic bone metastases and myeloma bone lesions are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alter quality of life and that have a huge…
- Conditions
- Metastases to Bone, Metastatic Breast Cancer, Metastatic NSCLC
- Trial name
- MEKANOS (NCT04170634)
- Testing
- Evaluation of the fracture risk using data from routine qCT (quantitative Computed Tomography) scan and numerical simulation
- Where
- 12 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
MEthods for LOcalization of Different Types of Breast Lesions
In the last decades, the proportion of breast cancer (BC) patients receiving breast-conserving surgery has increased steadily, reaching 70-80% in developed countries.
- Trial name
- MELODY (NCT05559411)
- Where
- Germany
- Volunteers
- 7,416 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Breast Cancer
Magseed Pro(R)/ Sentimag(R) Gen3
The purpose of this study is to provide prospective evidence that the Magseed Pro® marker /Sentimag® Gen3 system is safe and effective for marking A. suspicious/biopsy-proven positive axillary lymph nodes; and B.
- Trial name
- NCT05142787
- Testing
- Magseed Pro(R) and Sentimag(R) Gen3 by Endomagnetics
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 224 people
- Sponsor
- Endomagnetics Ltd.
Breast Neoplasms
Ultrasound Elastography of Breast Lesions
Our hypothesis is that the addition of ShearWave Elastography (SWE) to a conventional breast ultrasound examination provides useful information for the radiologist when imaging lesions in the breast, as compared to conventional…
- Trial name
- BE1 (NCT00716482)
- Where
- 16 sites in United States, France and 3 more
- Volunteers
- 1,681 people
- Sponsor
- SuperSonic Imagine
Atypical Ductal Hyperplasia (ADH) of the Breast
Atypical Lesions of the Breast: Close Observation Versus Excision (ALCOVE)
This study is designed to look at whether it is feasible to observe women with atypical ductal hyperplasia (ADH) of the breast, or whether surgical excision is necessary.
- Trial name
- ALCOVE (NCT01925586)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Yale University
Breast - Female, Dense Breast Parenchyma
Evaluation and Reclassification of ( BI-RADS 3) Breast Lesions in Dense Breast
This prospective study aims to compare combined breast ultrasound (US) and digital mammography (DM) with digital breast tomosynthesis (DBT) in the evaluation and reclassification of BI-RADS 3 (probably benign) breast lesions.
- Conditions
- Breast - Female, Dense Breast Parenchyma, Breast Lesion, Digital Mammography
- Trial name
- NCT07804147
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Breast Cancer Diagnosis, Breast Cancer Detection
Second-Look Ultrasound Post Contrast-Enhanced Mammography for Additional Lesions Characterization
This study investigates the utility of second-look ultrasound (US) following contrast-enhanced mammography (CEM) to characterize additional lesions detected during routine breast imaging.
- Trial name
- NCT06846814
- Testing
- CEM protocol
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Graziella di Grezia
Mastectomy, Segmental, Breast Neoplasm Malignant Female
Safety and Performance of REGENERA Breast Implant in Women Affected by Malignant Breast Lesion Treated by Lumpectomy
The goals of this clinical trial are: demonstrate the safety of REGENERA breast implant in patients undergoing lumpectomy of malignant breast lesions demonstrate the safety and performance of REGENERA in terms of investigator's…
- Trial name
- NCT05941299
- Testing
- REGENERA breast implant implantation
- Where
- 9 sites in Italy, Spain
- Volunteers
- 92 people
- Sponsor
- Tensive SRL
Breast Cancer
Using Diagnostic Tools to Stage Breast Cancer
This project is aimed at investigating the relative diagnostic and synergy of four state of the art breast imaging techniques (magnetic resonance imaging (MRI), full-field digital mammography (DMAM), ultrasound, and positron…
- Trial name
- NCT00367666
- Testing
- MRI, Digital Mammography, Ultrasound and Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pennsylvania
Breast Cancer
Clinical Effectiveness of CEM in Diagnosis of Additional Findings at Preoperative Breast Magnetic Resonance Imaging
In order to explain the value of adding CESM into the clinical pathway, and also to obtain the relevant clinical data to support future update of clinical guideline, we plan to evaluate the detection rate of CESM for additional…
- Trial name
- COMBO-I (NCT06475066)
- Testing
- contrast-enhanced spectral mammography
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Small Breast Lesions, Dense Breast Tissue
Molecular Breast Imaging: A Novel Technology for Detection of Malignant Breast Lesions
Detection of breast cancer as early as possible is an ongoing imaging challenge.The purpose of the current study is to assess the clinical performance of the new scintigraphic technology, a dedicated breast gamma camera composed…
- Conditions
- Small Breast Lesions, Dense Breast Tissue, Discrepancy With Clinical Examination, Equivocal Mammographic, Sonographic or MRI Lesion
- Trial name
- NCT01004666
- Where
- Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Premalignant Lesion
High-risk Breast Lesions: A Multicenter Retrospective Study
In this multicenter study, the goal was to document the excisional biopsy or follow-up results of high risk lesions diagnosed on image guided CNB/VAB, and evaluate the clinical, imaging and histologic features for associated…
- Trial name
- NCT04926688
- Where
- Turkey (Türkiye)
- Volunteers
- 1,345 people
- Sponsor
- Ege University
Breast Neoplasms, DWI
Multiple B-value Diffusion-weighted Imaging(DWI) in Evaluation of Breast Lesions
Breast cancer is the most commonly diagnosed cancer in women and its definite diagnose is still challenge for radiologist. This study is going to evaluate multi-b value diffusion weighted imaging in discrimination of breast…
- Trial name
- NCT02529384
- Testing
- Breast magnetic resonance scanning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Breast Cancer
Accuracy of VABB Elite 10G Versus BARD 14G CNB
In this study, patients whose breast ultrasound showed a space-occupying lesion and needed biopsy to clarify the pathology were selected as the research subjects.
- Trial name
- NCT04612439
- Testing
- VABB Elite 10G, BARD 14G CNB
- Where
- China
- Volunteers
- 1,470 people, healthy volunteers welcome
- Sponsor
- Fudan University
Breast Cancer
Dual-energy Contrast-enhanced (2D and 3D Mammography Versus Contrast-enhanced MRI)- A Pilot Study
This is a pilot study to evaluate 2D contrast-enhanced mammography image and 3D (tomosynthesis) contrast-enhanced images to contrast enhanced MRI in women with greater than 95% probability of breast cancer (BIRADS 5) or confirmed…
- Trial name
- NCT01433640
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hologic, Inc.
Breast Cancer
Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis
The objective is to better identify suspicious breast lesions that need to be biopsied for malignancy in women currently recommended for biopsy. The long-term goal is to reduce unnecessary biopsies and increase biopsy yield.
- Trial name
- NCT05369546
- Testing
- q3CB
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Hawaii
Breast Cancer
Cancer Predictive Score on Breast MRI
Sometimes, breast ultrasound and mammographic can't be diagnose suspsious lesions ( no substratum). So a MRI-guided breast biopsy is perfomed and disclosed ultimately benign lesions.
- Trial name
- NCT04914494
- Where
- France
- Volunteers
- 428 people
- Sponsor
- University Hospital, Montpellier
Breast Cancer
Histologic Diagnoses of Incidentally Detected Lesions on MRI
Patients who received breast MRI will be evaluated for a variety of indications including : # each indication : 1) known cancer staging for local exent, 2)high risk, 3)high suspicion clinical finding, 4)questionable mammo…
- Trial name
- NCT00579735
- Sponsor
- University of Arkansas
Breast Lesions
Angiogenesis in Early Breast Cancer for Prognosis Prediction
This study will investigate the association of angiogenesis in breast cancer measured by magnetic resonance imaging and biomarkers with long-term prognosis of patients.
- Trial name
- NCT00599105
- Testing
- magnetic resonance imaging
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Recurrent Breast Cancer, Stage IV Breast Cancer
Diagnostic Accuracy and Safety Study of FES PET/CT in Assessment of ER Status of Recurrent or Metastatic Breast Cancer
The standard diagnostic workup for recurrent or metastatic breast cancer includes biopsy and determination of tumor estrogen status according to National Comprehensive Cancer Network and European Society for Medical Oncology.
- Trial name
- NCT01986569
- Testing
- [18F]fluoroestradiol (FES)
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Asan Medical Center