Clinical trials: Breast Malignant Tumor
Breast Neoplasm
Preventing Chemotherapy-induced Peripheral Neuropathy Using PRESIONA Exercise Program
The aim of this study is to determinate if therapeutic exercise with blood flow restriction (BFR) during neoadjuvant chemotherapy potentialy neurotoxic could prevent the onset of chemotherapy induced peripheral neuropathy (CIPN)…
- Trial name
- PRESIONA (NCT04652609)
- Testing
- PRESIONA
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad de Granada
Breast Cancer, Breast Cancer Surgery
Pre-Surgery Positron Emission Mammography in Patients With Newly Diagnosed Breast Cancer
The purpose of the study is to determine the optimal, lowest dose of radioactive tracer required for Positron Emission Mammography (PEM), and the accuracy and reliability of PEM in pre-surgical evaluations for patients with newly…
- Trial name
- NCT01241721
- Testing
- Positron Emission Mammography (PEM)
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Swedish Medical Center
Breast Cancer
Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer
This study evaluates the acute toxicity and feasibility of repeat breast conserving therapy with preoperative accelerated partial breast re-irradiation (PAPBI) in female patients aged 51 years or older with ipsilateral recurrent…
- Trial name
- PAPBI-3 (NCT06362616)
- Testing
- Preoperative accelerated partial breast irradiation, Breast conserving surgery, Sentinel node procedure
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
The Diagnosis and Prognosis of Nonpalpable Breast Cancer Detected by the US vs Mammography: a Clinical Noninferiority Trial.
To evaluate and compare the sensitivity, specificity, AUC, pathology results of core needle biopsy and surgical pathology results coincidence rate, tumor staging, and DFS (disease-free survival) of US-detected nonpalpable breast…
- Trial name
- NCT04360616
- Testing
- imaging
- Where
- China
- Volunteers
- 1,277 people
- Sponsor
- The First Affiliated Hospital of the Fourth Military Medical University
Breast Cancer
A Study to Determine Biopsy Rate in Participants With a First Relapse of Breast Cancer
This is a retrospective, and observational cohort study to determine the proportion of breast cancer first relapses, that are biopsied. The duration of the study will be approximately 24 months.
- Trial name
- NCT02761616
- Testing
- eBC treated participants
- Where
- 4 sites in Argentina
- Volunteers
- 76 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer, Chemotherapy
Effects of an Integrative Day-care Clinic Program for Breast Cancer Patients During Chemotherapy
The aim of the study was to evaluate a new integrative day-care clinic concept for breast cancer patients receiving chemotherapy. This is an explorative pilot study. Therefore, all outcomes are analyzed exploratively.
- Conditions
- Breast Cancer, Chemotherapy, Mind-Body-Medicine, Acupuncture
- Trial name
- NCT03868865
- Testing
- Integrative mind-body-medicine group program
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Universität Duisburg-Essen
Breast Cancer
Radiation Therapy in Women With Low Risk Early-Stage Breast Cancer Who Have Undergone Breast Conservation Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.
- Trial name
- IMPORT (NCT00814567)
- Testing
- radiation therapy
- Where
- United Kingdom
- Volunteers
- 2,018 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Breast Cancer, Breast Cyst
Pilot Clinical Study on a Low-power Electromagnetic Wave Breast Imaging Device for Cancer Screening Purposes.
The trialed investigational medical imaging device is a low-power microwave breast imaging system for cancer screening purposes. It is an active device which uses non-ionizing radiation.
- Trial name
- NCT03475992
- Testing
- Low-power microwave breast imaging system
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- MVG Industries SAS
Triple Negative Breast Cancer (TNBC)
A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer
The purpose of this study is to explore the feasibility and acceptability of a nurse-led, coping, and supportive care intervention for patients with triple-negative breast cancer.
- Trial name
- RESTORE (NCT07513311)
- Testing
- RESTORE, Enhanced Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Fulvestrant or Tamoxifen in Treating Postmenopausal Women Who Are Undergoing Surgery for Ductal Carcinoma in Situ of the Breast
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using fulvestrant or tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00126464
- Testing
- fulvestrant, tamoxifen citrate, conventional surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ
Hormone Therapy Or Chemotherapy Before Surgery Based on Gene Expression Analysis in Treating Patients With Breast Cancer
This randomized pilot clinical trial studied whether the Oncotype DX gene expression "Recurrence Score" (RS) would be useful for helping make a decision about which type of pre-operative treatment, hormone therapy or chemotherapy…
- Conditions
- Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ, Stage II Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT01293032
- Testing
- Neoadjuvant Therapy, Therapeutic Conventional Surgery, Laboratory Biomarker Analysis
- Where
- 8 sites in United States, Canada
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Head and Neck Cancer
Using Traditional Acupuncture in the Management of Cancer Treatment Related Lymphoedema
RATIONALE: Acupuncture and moxibustion may improve well-being and quality of life in patients with lymphedema caused by breast cancer or head, neck, and throat cancer.
- Conditions
- Breast Cancer, Head and Neck Cancer, Lymphedema
- Trial name
- AMWELL-SL (NCT00828516)
- Testing
- Acupuncture and moxibustion
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- East and North Hertfordshire NHS Trust
Sexual Dysfunction
BREast Cancer And Sexuality Treatment
The purpose of this project is to compare the effects of a group mindfulness treatment versus a group sex education on sexual desire, sexual distress, and sexual pain in breast cancer (BrCa) survivors.
- Trial name
- BREAST (NCT04472104)
- Testing
- MBCT-S, SexEd
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- University of British Columbia
Breast Cancer
Vinorelbine Metronomic Plus Bevacizumab as Salvage Therapy for Breast Cancer
To evaluate the efficacy of metronomic oral vinorelbine taken three times a week without break plus bevacizumab as salvage treatment in patients with metastatic breast cancer.
- Trial name
- NCT00694200
- Testing
- Vinorelbine, Bevacizumab
- Where
- 9 sites in Greece
- Volunteers
- 13 people
- Sponsor
- Hellenic Oncology Research Group
Breast Cancer
Efficacy and Safety of Non Invasive Vagal Stimulation to Prevent Chemotherapy-induced Nausea
Despite pharmaceutical innovations, chemotherapy induced nausea is frequent and largely participating to alter our patients quality of life.
- Trial name
- SILENCE (NCT04937309)
- Testing
- non invasive auricular vagal stimulation, usual medical treatment
- Where
- 8 sites in France
- Volunteers
- 338 people
- Sponsor
- University Hospital, Tours
Bone Pain in Stage I - III Breast Cancer
NOLAN: Naproxen or Loratadine and Neulasta
The primary objective of the study is to estimate the difference in bone pain between breast cancer patients receiving chemotherapy and pegfilgrastim and either no prophylactic intervention, prophylactic naproxen, or prophylactic…
- Trial name
- NOLAN (NCT01712009)
- Testing
- Naproxen, Loratadine, Pegfilgrastim
- Where
- 83 sites in United States
- Volunteers
- 600 people
- Sponsor
- Amgen
Breast Cancer, Cognitive Dysfunction
Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer
Investigator propose the first French randomized comparative study to assess the efficacy of a remotely supervised online cognitive stimulation program, compared to an unsupervised online cognitive exercise intervention, in…
- Trial name
- COG STIM 2 (NCT06027632)
- Testing
- Cognitive exercises with supervision, Cognitive exercises without supervision
- Where
- 25 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Francois Baclesse
HER 2 Positive Advanced Breast Cancer
HER2-positive Breast Cancer Without Intravenous Neoadjuvant Therapy
1. The primary goal of this clinical trial is to evaluate the pathological complete response (pCR) rate of oral paclitaxel solution combined with subcutaneous pertuzumab and trastuzumab in the neoadjuvant treatment of early or…
- Trial name
- NCT07848633
- Testing
- - Oral paclitaxel solution: 200 mg/m² orally twice daily on Day 1 and Day 8 of each cycle, subcutaneous pertuzumab and trastuzumab fixed-dose combination for a total of 6 cycles
- Volunteers
- 65 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Breast Cancer Female
Robotic Versus Conventional or Endoscopic Nipple Sparing Mastectomy in the Management of Breast Cancer-Prospective Study
This study will prospectively evaluate the surgical outcomes of robotic nipple sparing mastectomy (NSM) compared with endoscopic assisted NSM or conventional NSM in the management of breast cancer.
- Trial name
- RCENSM-P (NCT04037852)
- Testing
- robotic assisted nipple sparing mastectomy, Endoscopic assisted nipple sparing mastectomy, Conventional nipple sparing mastectomy
- Where
- 11 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Changhua Christian Hospital
Breast Cancer, Elderly
Gene Polymorphisms and Gene Products as Biological Markers of Aging and Correlation With Clinical Geriatric Assessment, Tolerance of Chemotherapy and Outcome in Elderly Breast Cancer Patients
The goal is to study the biology of aging in breast cancer patients, and to study the impact of chemotherapy on aging related blood biomarkers.
- Trial name
- EBS (NCT00849758)
- Where
- 2 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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