Clinical trials: Breast-conserving Surgery
Stage IA Breast Cancer, Stage IB Breast Cancer
Intraoperative Electron Beam Radiotherapy Boost in Treating Patients With Stage I-II Breast Cancer Undergoing Surgery With Reconstruction
This phase II trial studies the side effects of intraoperative electron beam radiotherapy boost and to see how well it works in treating patients with stage I-II breast cancer undergoing surgery with reconstruction.
- Conditions
- Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer
- Trial name
- NCT02927912
- Testing
- Electron Beam Therapy, Lumpectomy, Quality-of-Life Assessment
- Where
- 5 sites in United States, Canada
- Volunteers
- 108 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
The purpose of this randomized Phase III study is to determine whether preoperative focused microwave heat treatment and chemotherapy combined are more effective than preoperative chemotherapy alone in the treatment of large…
- Trial name
- Medifocus301 (NCT01204801)
- Testing
- Focused Microwave Thermotherapy, Chemotherapy (control)
- Where
- 2 sites in United States, Canada
- Volunteers
- 238 people
- Sponsor
- Medifocus, Inc.
Breast Cancer
The Impact of Surgeon-Interpreted Intraoperative Margin Assessment During Breast Conserving Surgery on Postoperative Treatment
To learn if Pegulicianine Fluorescence-Guided Surgery (pFGS), which is part of the Lumicell Direct Visualization System, and Digital Breast Tomosynthesis (DBT) can improve the identification of tumor margins during a partial…
- Trial name
- NCT07140965
- Testing
- Pegulicianine Fluorescence-Guided Surgery, Digital Breast Tomosynthesis, Breast Conserving Therapy
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Surgery
Conserving Breast Surgery - Comparison of Conventional With Sonography
Aim of the study is to test whether surgical removal of a tumor under sonographic control as compared to conventional method reduces the rate of resections and local relapse
- Trial name
- MAC-001 (NCT02222675)
- Testing
- Sonography assisted breast surgery, Conventional breast surgery
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Tuebingen
Early-Stage Breast Carcinoma
Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer
Hypofractionation with simultaneous integrated boost has been investigated in a few trials and appears to be safe and feasible. Investigators initiated this multicenter two-armed phase III prospective trial to analyse the…
- Trial name
- HYPOSIB (NCT02474641)
- Testing
- Standard Radiation, Hypofractionation with SIB
- Where
- 88 sites in Germany
- Volunteers
- 2,324 people
- Sponsor
- University Hospital Schleswig-Holstein
Breast Cancer Female
Hypofractionated Radiation Therapy With Concomitant Boost in Treating Women After Breast Conserving Surgery
This phase II study is to evaluate the safety of hypofractionated whole breast radiation (HFRT) with simultaneous tumor bed boost(SIB) in women with early breast cancer after breast-conserving surgery.
- Trial name
- NCT03320421
- Testing
- Radiation therapy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Cancer, HER2-negative Breast Cancer
Clinical Study of Breast Conserving Surgery Combined With Intraoperative Radiotherapy for Early Breast Cancer
A Single-center, open, prospective study，for analyzing the local recurrence rate, the incidence of incision complications and the aesthetic effect of intraoperative radiotherapy in early breast cancer patients after…
- Trial name
- NCT06375798
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University Fourth Hospital
Early-Stage Breast Cancer
1-Week Versus 3-Week PBI
This non-inferiority, phase 3 clinical trial evaluates the cosmetic non-inferiority of a one-week regimen (26 Gy/5 Fx) versus a three-week regimen (40 Gy/15 Fx) using intensity-modulated radiation therapy (IMRT) for partial…
- Trial name
- NCT07832279
- Testing
- 3-week PBI, 1-week PBI
- Where
- China
- Volunteers
- 818 people
- Sponsor
- Fudan University
Breast Cancer - Ductal Carcinoma in Situ (DCIS), Breast-Conserving Surgery
Reoperation Rate in Breast-Conserving Surgery Using Confocal Histolog® Scanner for Intraoperative Margin Assessment
This PMPF study is proposed to evaluate in real life the reoperation rates (ROR) of breast cancer and/or DCIS surgery when including the use of the HLS in the context of breast lumpectomy margin assessment.
- Trial name
- SHIELD (NCT05946759)
- Testing
- Histolog Scanner
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- SamanTree Medical SA
Breast Cancer
Intraoperative Use of ClearEdge Device in Breast Conserving Surgery
Multi center, pivotal prospective, randomized clinical trial The proposed randomized controlled study will evaluate the benefits of adding the ClearEdge imaging device to the Standard of Care (SoC) of margins assessment in breast…
- Trial name
- NCT05456373
- Testing
- ClearEdge device
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- LS BioPath
Breast Neoplasms
Comparison of Intra-operative Radiotherapy With Post-operative Radiotherapy for Women With Ductal Carcinoma in Situ
Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation during surgery followed by external-beam radiation to the entire breast may kill more tumor cells.The clinical trial is conducting to compare the…
- Trial name
- NCT02389699
- Testing
- Intraoperative Radiotherapy, Whole breast radiation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Liao Ning
Breast Cancer, Early Stage
Ablation Compare With Surgery for Early Breast Cancer
Breast-conserving surgery has been widely used in clinical practice, but surgical incisions still impact postoperative patient satisfaction with breast appearance.
- Conditions
- Breast Cancer, Early Stage, Hormone Receptor Positive, Ablation
- Trial name
- NCT07484087
- Testing
- breast conserving surgery, cryo-thermal ablation
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Peking University People's Hospital
Early-Stage Breast Cancer
PBI for Low-risk Breast Cancer
This non-inferiority, phase 3 clinical trial evaluates the cosmetic non-inferiority of a one-week regimen (26 Gy/5 Fx) versus a three-week regimen (40 Gy/15 Fx) using intensity-modulated radiation therapy (IMRT) for partial…
- Trial name
- NCT07814365
- Testing
- 3-week PBI, 1-week PBI
- Where
- China
- Sponsor
- Fudan University
Breast Neoplasm Female, Breast Cancer
Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Breast conserving surgery (BCS) is performed on patients with breast cancer to resect and completely remove the cancer while conserving as much of the surrounding healthy tissue as possible.
- Trial name
- NCT04815083
- Testing
- Aminolevulinic Acid Hydrochloride, Eagle V1.2 Imaging System
- Where
- 7 sites in United States
- Volunteers
- 57 people
- Sponsor
- SBI ALApharma Canada, Inc.
Breast Cancer - Female, Surgery of Breast Cancer
Comparing Patient Reported Outcomes and Clinical Outcomes Based on Different Scar Placement in Patients Undergoing Standard Breast Conserving Surgery for Breast Cancer: The PROM-S Study.
This study is for patients with breast cancer and the objective is to compare patient reported outcome measures (PROMs) based on scar placement in patients undergoing standard breast-conserving surgery (sBCS).
- Trial name
- PROM-S (NCT07116642)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Early-Stage Breast Carcinoma
PICTURE Breast XS: Patient Information Combined for Local Therapy oUtcome Assessment in bREast Cancer - Cross-sectional
This project which is fully funded by the European Union FP7 Program is designed to pull together all the information we obtain from scans and x-rays to design a personalised 3-D digital model of each patient, their anatomy and…
- Trial name
- PICTURE XS (NCT02310984)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 222 people
- Sponsor
- University College, London
Breast Neoplasms
The Breast Surgery EnLight and LightPath Imaging System Study
This study will correlate the resection margin status of the breast cancer tumour (WLE specimen), cavity shavings (if any) and breast cavity, and the metastatic status of axillary lymph nodes as determined by EnLight, LightPath…
- Trial name
- NCT02151071
- Testing
- EnLight, LightPath
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Lightpoint Medical Limited
Breast Cancer
Study the Role of Positron Emission Mammography in Pre-surgical Planning for Breast Cancer
Women with newly diagnosed breast cancer anticipating breast-conserving surgery are enrolled into the study and will undergo both high-resolution positron emission mammographic (PEM) imaging and contrast-enhanced magnetic…
- Trial name
- NCT00484614
- Testing
- Positron Emission Mammography, Magnetic Resonance Imaging
- Where
- 6 sites in United States
- Volunteers
- 472 people
- Sponsor
- Naviscan PET Systems
Breast Cancer
Multiple Oncological Serial Scans Study
This is a pilot study comparing the appearance and volume of the post surgical region in the intact breast, as determined by 3 modalities: computed Xray tomography (CT), 3 Dimensional ultrasound (USS), Magnetic resonance imaging…
- Trial name
- MOSS (NCT01246726)
- Testing
- CT SCAN, MRI scan, 3D Ultrasound scan
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Breast Cancer, Pectoral Nerves Block
Comparing the QoR of PECS Block and GA in Breast-conserving Surgery With Sentinel Lymph Node Biopsy
The aim of this randomized controlled trial (RCT) is to assess the Quality of Recovery (QoR) in Breast-conserving Surgery (BCS) with Sentinel Lymph Node Biopsy (SLNB) using Pectoral Nerves (PECS) Block and General Anesthesia…
- Conditions
- Breast Cancer, Pectoral Nerves Block, Breast-Conserving Surgery, Sentinel Lymph Node Biopsy
- Trial name
- NCT06120439
- Testing
- PECS II combined with intercostal nerve blockade;, General anesthesia with laryngeal mask
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Jun Zhang