Clinical trials: Breath Analysis
Covid19
Performance Assessment of SARS-CoV-2 Detection Breath Biopsy - SARS-CoV-2 Study
The primary aim of this study is to investigate the performance of Breath Biopsy RD for the detection of SARS-CoV-2 in both a clinical and at home setting.
- Trial name
- COVID (NCT04508556)
- Testing
- Breath Biopsy face masks with removable filters and fitted PVA strip, Nasopharyngeal swab, oropharyngeal swabs
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Owlstone Ltd
Acute Liver Failure
13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF
The ALFSG-MBT protocol is for a multicenter, open label, non-randomized study to determine the value of Breath Identification® (BreathID®) N-(4-Methoxy-13C-phenyl)acetamide (13C-Methacetin) Breath Test System in predicting the…
- Trial name
- ALFSG-MBT (NCT02786836)
- Testing
- 13C-Methacetin
- Where
- 11 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy Subjects, Chronic Liver Disease
¹³C-Methacetin Breath Test (MBT) Methodology Study
Several factors will be tested to see if they have an influence on the methacetin breath test results. Each one of the factors has been raised as a possible source of distortion of the MBT result. I.
- Conditions
- Healthy Subjects, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT01205074
- Testing
- 13C Methacetin Breath Test, Grape fruit juice, Non selective beta blocker - Propranolol
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Lung Cancer, Non-Small Cell Lung Cancer
Breath Analysis for Evaluation of Radiation Exposure in Lung Cancer Patients Treated With Radiation
Patients treated with radiation therapy for lung tumors can experience inflammation after treatment. This study hopes to evaluate the use of breath analysis to evaluate changes in the composition of exhaled breath in patients…
- Conditions
- Lung Cancer, Non-Small Cell Lung Cancer, Small Cell Lung Cancer
- Trial name
- NCT01182155
- Testing
- Exhaled Breath Sampling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Prostate Cancer, Radiotherapy Side Effects
Using Breath, Cell Free DNA and Image Analysis to PRedIct Normal TissUe and Tumour Response During Prostate Cancer SBRT
Personalisation of radiotherapy dose based on real-time assessments of normal tissue and tumour response would maximise cure and minimise treatment related toxicity.
- Conditions
- Prostate Cancer, Radiotherapy Side Effects, Volatile Organic Compounds, DNA Damage
- Trial name
- PRINToUT (NCT04081428)
- Testing
- Stereotactic Body Radiotherapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Lothian
Inflammatory Bowel Diseases
AIRE-2 Device for Study of Breath Analysis in IBD
The goal of this Prospective single-blinded intervention feasibility study is the utilization of the AIRE-2 device and FoodMarble app to elucidate the interplay among diet, symptoms, and microbial fermentable features in IBD…
- Trial name
- AIRE-2 (NCT06541938)
- Testing
- low FODMAP diet, Lactose Sachet, Fructose Sachet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Gastrointestinal Dysfunction
Gastric Emptying Validation Pilot Study (MRI Val)
The primary aim of this study is to assess (in healthy volunteers) the rate at which a glucose drink leaves the stomach by sequential magnetic resonance imaging (MRI) of the stomach contents using a 0.5 tesla upright MRI scanner…
- Trial name
- MRIVal (NCT05765123)
- Testing
- Oral glucose tolerance test
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Lactose Intolerance
Effect of a Probiotic Formulation in Adults With Lactose Intolerance and Methanogenic Intestinal Overgrowth
Introduction: Lactose intolerance (LI) is characterized by specific gastrointestinal symptoms following the consumption of dairy products and lactose-containing foods, symptoms that may also be experienced by individuals with…
- Trial name
- LAC L-134/33 (NCT07652827)
- Testing
- Probiotic formulation
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Universidad de Concepcion
Pulmonary Fibrosis
Exhaled Breath Analysis Using eNose Technology as a Biomarker for Diagnosis and Disease Progression in Fibrotic ILD
The ILDnose study a multinational, multicenter, prospective, longitudinal study in outpatients with pulmonary fibrosis. The aim is to assess the accuracy of eNose technology as diagnostic tool for diagnosis and differentiation…
- Trial name
- ILDnose (NCT04680832)
- Testing
- Electronic nose
- Where
- 5 sites in Australia, France and 3 more
- Volunteers
- 600 people
- Sponsor
- Erasmus Medical Center
Autonomic Nervous System Diseases
Autonomic Responses During the Valsalva Maneuver and Deep Breathing Test Depend on the Experimental Setup
The purpose of this study is to determine the effects of procedural differences during the Valsalva maneuver and deep breathing test in autonomic nervous system testing.
- Trial name
- NCT02397681
- Testing
- Autonomic Function Testing
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center
Liver Diseases, Liver Cancer
Breath Analysis Based Disease Biomarkers
The purpose of the study is to develop a clinical test based on breath analysis that can be used for disease diagnosis or prognosis.
- Conditions
- Liver Diseases, Liver Cancer, COVID19
- Trial name
- NCT04341012
- Testing
- Collection of breath sample
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancer
Non-Invasive Biomarkers For Early Detection Of Lung Cancers
Recent studies have shown that low-dose chest CT scans can detect lung cancers in high-risk populations (age >50yo, >30 pack-years of tobacco use), and can lower cancer mortality.
- Trial name
- ISRUSAL01 (NCT01580332)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Douglas W. Johnson MD, FACR
Breath Test
HOspital Versus Primary Care Breath Test Environment (HOPE) Study
Through the HOPE study, the intention would be to determine whether exhaled breath volatile organic compound (VOC) profiles in Primary care differ from Secondary care.
- Trial name
- HOPE (NCT06611293)
- Testing
- Breath test
- Where
- 2 sites in United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obstructive Sleep Apnea
Effect of CPAP Therapy on Molecular Breath Patterns in Patients With OSA
Determination of changes in molecular breath patterns in OSA patients, naïve for OSA treatment before and after one month of CPAP therapy by untargeted, secondary electrospray ionisation-high resolution mass spectrometry…
- Trial name
- BrOSA (NCT04638933)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 53 people
- Sponsor
- Malcolm Kohler
Pulse Spectrum Analysis, Pulmonary Function
Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath Condensate
Our hypothesis is that radial arterial pulse may reflect the severity and airway function in asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery in adult asthmatics, and evaluate its…
- Conditions
- Pulse Spectrum Analysis, Pulmonary Function, FeNO, Metabolites
- Trial name
- NCT01719393
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Respiratory Distress Syndrome, Newborn, Ventilator-associated Lung Injury
Positioning During SBT in NICU Infants
Mechanical ventilation is a life-sustaining intervention in premature infants with respiratory difficulties. There is relative consensus when to intubate and provide positive pressure mechanical ventilation in the presence of…
- Trial name
- NCT02835209
- Testing
- Work of breathing during SBT
- Sponsor
- Christiana Care Health Services
Respiratory Diseases, Neurological Disorders
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents
This study is to investigate breath analysis (breath metabolomics) combined with established bioinformatic tools as a platform for companion diagnostics.
- Conditions
- Respiratory Diseases, Neurological Disorders, Type 1 Diabetes
- Trial name
- EBECA (NCT04461821)
- Testing
- Real-time SESI-MS breath analysis, Off-line breath analysis, Blood analysis
- Where
- Switzerland
- Volunteers
- 3,600 people
- Sponsor
- University Children's Hospital Basel
Pulmonary Disease, Chronic Obstructive
Prednisolone Novel Endpoint Study in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Prednisolone will be used as a model medication to identify new clinical outcomes for future evaluation of new therapies in short-term studies (up to 4 weeks) in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT00379730
- Testing
- Prednisolone
- Where
- 5 sites in Argentina, Chile and 2 more
- Volunteers
- 90 people
- Sponsor
- GlaxoSmithKline
Peptic Ulcer, Hemorrhage
Rapid Urease Test for Diagnosis of H. Pylori Infection in Patients With Peptic Ulcer Bleeding
Rapid urease test (RUT) is the most commonly used biopsy-based method to diagnose Helicobacter pylori (Hp) infection because of its simple, rapid and accurate characters.
- Trial name
- NCT01282853
- Testing
- endoscopic biopsy
- Where
- Taiwan
- Volunteers
- 116 people
- Sponsor
- Far Eastern Memorial Hospital
Bronchiectasis
Assessment of an Exhaled Breath Test to Detect Bronchiectasis
To investigate whether the breath test is able to detect bronchiectasis using breathomics. This study was conducted with a prospective specimen collection, evaluator-blinded, case-controlled clinical study designed to evaluate…
- Trial name
- NCT05293314
- Testing
- An exhaled breath test
- Where
- China
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China