Clinical trials: Breathlessness
Covid19, Dyspnea
Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19
A novel corona virus emerged in 2019 causing Corona Virus Disease 2019 (covid-19). In one year more than 80 000 000 cases worldwide were documented.
- Trial name
- NCT04732663
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Respiratory Distress, Hypoglycemia
Observational Study of Infants Born at 34 to 37 Weeks of Gestation Until the Age of 1 Year
Late preterm infants are at an increased risk for short and long term morbidity (during the 1st year of life, their neurodevelopmental status may also be delayed as compared to infants born at term).
- Conditions
- Respiratory Distress, Hypoglycemia, Feeding Intolerance, Jaundice
- Trial name
- NCT00550069
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Dyspnea, Breathlessness
Breathlessness During Exercise: Experience and Memory
Breathlessness during exertion is a major limiting factor for patients' physical capacity and activity. Increased exertional breathlessness often results in impaired activity, spiraling deconditioning and further worsening of…
- Trial name
- NCT03458182
- Testing
- Added exercise
- Where
- Sweden
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Magnus Ekström
Dyspnea; Cardiac
Test-Retest Reliability of Cardiopulmonary Exercise Testing With Echocardiography
CPETecho is progressively employed in diagnostic settings for pathophysiological detection, offering comprehensive assessment of both pulmonary and cardiac functions.
- Trial name
- REPEATCPETecho (NCT07281534)
- Testing
- CPETecho
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Asthma
Epinephrine Inhalation Aerosol USP, CLINICAL STUDY-B3 FOR ASSESSMENT OF PHARMACOKINETICS
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA134a propelled Metered Dose Inhaler (MDI) (E004), using a stable isotope deuterium-labeled epinephrine…
- Trial name
- NCT01255709
- Testing
- Arm T1: Primatene Mist HFA, Arm T2: Primatene Mist HFA, Arm C: Primatene Mist (epinephrine inhalation aerosol, USP)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Breathlessness
Inhaled Nebulized Furosemide & Physical Activity-Related Breathlessness
Breathlessness on exertion is a common and troublesome complaint of individuals with restrictive lung disorders. In these adults, breathlessness contributes to physical activity-limitation and avoidance and an adverse…
- Trial name
- NCT01851980
- Testing
- CWS, Furosemide
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Chest Pain, Shortness of Breath
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart…
- Trial name
- NCT06927973
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Obstructive Pulmonary Disease
Pathophysiological Mechanisms of Dyspnea and Activity-limitation in Mild Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a growing cause of death, disability and health care costs in Canada. Nevertheless, COPD remains largely under-diagnosed and under-treated, particularly in its early stages.
- Trial name
- NCT00975403
- Testing
- Dead space breathing, Room air breathing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Airway Obstruction, Dyspnea
Heliox in Experimental Upper Airway Obstruction
Currently it is common medical wisdom that HELIOX (mixture of Helium in Oxygen) with a fraction of Helium below 60% is not effective in reducing airway obstruction.
- Trial name
- NCT00788788
- Testing
- HELIOX
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Smoking
Functional Capacity, Subjective Dyspnea and Fatigue in Smokers
Smoking remains a significant public health problem among the young adult population. Epidemiological studies in Turkey show a steadily decreasing age of smoking initiation and a remarkably high rate of smoking among…
- Trial name
- NCT07520981
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Istinye University
COVID-19 Respiratory Infection
Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue
The objective of this project is to assess the effects of a 2-month cardiopulmonary rehabilitation program on cardiorespiratory fitness in long COVID19 patients.
- Trial name
- COVID-Rehab (NCT05035628)
- Testing
- Cardiopulmonary exercise training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Work of Breathing
The Role of Breathing Perception in Respiratory Control
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing…
- Trial name
- NCT07470099
- Testing
- Ambient Noise, Increased Auditory Feedback, Noise Distraction
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cystic Fibrosis Patients
Effects of Breathing Exercises Combined With Endurance and Strength Training in Patients With Cystic Fibrosis.
Cystic fibrosis (CF) is a multi-system inherited disease. It's a common autosomal recessive illness. It mostly affects the lungs, liver, and pancreatic exocrine glands, as well as the intestines.
- Trial name
- NCT05655637
- Testing
- Exercise
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Healthy, Dyspnea
Aerosol Inhalation Treatment for Dyspnea
The purpose of this protocol is to develop and test optimal delivery of aerosol furosemide, a treatment that has the potential to significantly improve symptom management and enhance the quality of care for patients with…
- Trial name
- NCT01440764
- Testing
- Furosemide, Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy Adults
Effects of Isocapnic Respiratory Muscle Endurance Training in Healthy Adults
Respiratory muscle training (RMT) strengthens breathing muscles and may improve exercise performance and reduce breathlessness. However, different training methods and devices create controversy in the field.
- Trial name
- NCT07103291
- Testing
- Respiratory muscle endurance training
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Obstructive Pulmonary Disease
Effects of Diaphragm and Abdominal Muscle Training on PFT and Dyspnea Among COPD Obstructive Pulmonary Disease Patients.
It will be a randomized control trial at Services Hospital Lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to Group A and Group B .
- Trial name
- NCT05587829
- Testing
- • Diaphragmatic breathing technique, basic breathing technique
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Post-Acute COVID-19, Post COVID-19 Condition
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
- Conditions
- Post-Acute COVID-19, Post COVID-19 Condition, Post Viral Fatigue, Dyspnea
- Trial name
- PASC VQ (NCT05866952)
- Testing
- Computed Tomography of the Chest
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
COVID-19, Dyspnea
Short Term Results of Tele-Rehabilitation
Most people who have coronavirus disease (COVID-19) recover completely without any sequelae. However, some patients continue to experience symptoms of COVID-19 even though their tests turn negative.
- Trial name
- NCT05381675
- Testing
- Tele-rehabillitation, Prescribed Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Work of Breathing
The Role of Heliox in Respiratory Control
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing…
- Trial name
- NCT07424014
- Testing
- Heliox inspirate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Trauma, Rib Fractures
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures
The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes.
- Conditions
- Trauma, Rib Fractures, Chest Wall Disorder, Respiratory Insufficiency
- Trial name
- NCT06533904
- Testing
- Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University