Clinical trials: Broccoli Sprout
Environmental Carcinogenesis
Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants
This study will examine the extent to which lower doses of a broccoli-derived beverage enhance the detoxication of air pollutants excreted in urine as compared to an maximal dose shown to be effective previously.
- Trial name
- NCT02656420
- Testing
- Broccoli Sprout-derived Beverage
- Where
- China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Asthma, COPD
The Effects of Broccoli Sprout Extract on Obstructive Lung Disease
The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.
- Trial name
- NCT00994604
- Testing
- broccoli sprout extract
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Effect of Sulforaphane-rich Broccoli Sprout Homogenate on Ozone Induced Inflammation Through Modulation of NRF2
Purpose: To determine if modulation of NRF2 with a Sulforaphane enriched supplement modifies responses to O3. Participants: Recruitment of up to 70 healthy volunteers, ages 18-50, for completion of 36 volunteers.
- Trial name
- BroccOz (NCT01625130)
- Testing
- Broccoli sprout homogenate, alfalfa sprout homogenate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Physical Performance, Glucose
Timing of Broccoli Sprout Intake to Improve Exercise Performance
This study examines how the timing of intake of a broccoli sprout-based drink (a natural source of isothiocyanates, ITCs) affects physiological responses, recovery, and performance after a standardized endurance cycling session.
- Conditions
- Physical Performance, Glucose, Glycogen Metabolism, Lactate
- Trial name
- NCT07461194
- Testing
- Broccoli sprout drink (isothiocyanate-rich
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Histone Deacetylase (HDAC) Activity
Dietary Histone Deacetylase Inhibitors (HDAC)
This pilot, three-week study will help scientists understand more about how the foods people eat can modify histone deacetylases, enzymes the body produces naturally.
- Trial name
- NCT01543074
- Testing
- Garlic oil, BSE
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Epidermolysis Bullosa Simplex, Pachyonychia Congenita
Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin
Adult participants will apply a broccoli sprout extract-jojoba oil compound to one arm every night under occlusion for 1 week. Jojoba oil alone will be applied to the other arm.
- Trial name
- NCT02592954
- Testing
- Jojoba oil with broccoli sprout extract
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Environmental Carcinogenesis
Broccoli Sprout Intervention in Qidong, P.R. China
This study is a 12 week placebo-controlled Phase II broccoli sprout intervention to be conducted in Qidong, P.R. China. One thousand two hundred people from the farming townships will be screened and three hundred eligible…
- Trial name
- NCT01437501
- Testing
- Broccoli Sprout Extract Beverage
- Where
- China
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy Adult Volunteers
Effects of 2 Different Broccoli Sprout Containing Supplements on Nasal Cells in Healthy Volunteers
Purpose: To compare the change in nasal cell HO-1 expression induced by two different preparations of sulforaphane (SFN)-containing nutritional supplements Participants: Healthy nonsmoking young adults, age 18-35 Procedures…
- Trial name
- Broccosprout (NCT01129466)
- Testing
- Supplement A followed by Supplement B, Supplement B followed by Supplement A
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Smoking
Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism
To determine whether glucobrassicin-rich Brussels sprouts can favorably modify the metabolism of the polycyclic aromatic hydrocarbon deuterated phenanthrene ([D10]phe) in current and former smokers
- Trial name
- NCT02999399
- Testing
- Brussel Sprouts, Deuterated Phenanthrene
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters
This phase II randomized, placebo-controlled trial evaluates whether daily supplementation with broccoli seed and sprout extract (BSSE), also known as Avmacol Extra Strength (ES), enhances the body's natural ability to detoxify…
- Conditions
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Occupational Malignant Neoplasm
- Trial name
- NCT06009926
- Testing
- Acetaminophen, Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Healthy Subject
Broccoli Sprout Extracts in Healthy Volunteers: A Pilot Study of Nrf2 Pathway Modulation in Oral Mucosa
A pilot study has been designed to determine (primary objective) if three brief interventions with three oral BSE regimens will alter mRNA biomarkers of Nrf2 pathway signaling, including NQO1, GSTs and AKRs, in the oral mucosa of…
- Trial name
- BSE (NCT02023931)
- Testing
- Broccoli Sprout Extract (BSE)
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Julie E. Bauman, MD, MPH
Allergic Airway Disease
Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose
Allergic airway disease is a term used to describe conditions such as allergic rhinitis and asthma. Among other causative agents, air pollutants and diesel exhaust in particular, have been shown to create and also worsen existing…
- Trial name
- NCT00882115
- Testing
- Broccoli sprout extract (BSE)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Rhinitis,Allergic
Effects of Broccoli Sprout Extract on Allergy Rhinitis
Allergic rhinitis is a common illness suffered among US Veterans. There are medications that help relieve allergy symptoms, including nasal steroid sprays and antihistamines.
- Trial name
- NCT02885025
- Testing
- Broccoli Sprout Extract, fluticasone nasal, normal saline nasal spray
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sickle Red Blood Cell, Fetal Hemoglobin
Effect of Broccoli Sprouts Homogenate on SS RBC
The overall purpose of this study is to obtain a better understanding of the biological response of red blood cells to sulforaphane contained in fresh broccoli sprouts that have been put through a blending process.
- Conditions
- Sickle Red Blood Cell, Fetal Hemoglobin, Oxidative Stress
- Trial name
- BSH (NCT01715480)
- Testing
- Broccosprouts® (Brassica Protection Products LLC) homogenate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Cigarette Smoking-Related Carcinoma
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
This phase II trial tests whether broccoli seed and sprout extract works to break down cancer causing substances of tobacco in heavy smokers. Smokers are at increased risk for developing lung, head and neck, and other cancers.
- Trial name
- NCT05121051
- Testing
- Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers
This randomized early phase I trial studies how well broccoli sprout/broccoli seed extract supplement works in decreasing toxicity in heavy smokers.
- Trial name
- NCT03402230
- Testing
- Broccoli Sprout/Broccoli Seed Extract Supplement, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Healthy Volunteers
Effect of Broccoli Sprout on Blood Levels of Sulforaphane to Reduce Responsiveness of Immune System
The investigators suggest that inducing anti-oxidant enzymes indirectly may be an effective means of providing vascular protection.
- Trial name
- NCT01357070
- Testing
- Brocco-sprout homogenate, Alfalfa sprout homogenate
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diet, Healthy
Discovery of Biological Signatures for Cruciferous Vegetable Intake (Single Serving)
The purpose of this project is to study the molecular and metabolic profiles in human plasma, urine and microbiome composition following the consumption of broccoli sprouts.
- Trial name
- NCT04641026
- Testing
- Broccoli sprouts, Deuterium oxide-labelled broccoli sprouts, Alfalfa sprouts
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Oregon State University