Clinical trials: Broken Leg, active
Fracture Arm, Fracture Leg
Accuro XV Ultrasound Imaging System for BoneEnhance and Fracture Detection Algorithms
The Accuro XV is a cart-based, bedside ultrasound instrument that incorporates new signal processing-based technologies for enhanced bone and soft-tissue imaging.
- Conditions
- Fracture Arm, Fracture Leg, Wrist Injury, Ankle Injury
- Trial name
- NCT07853768
- Testing
- Accuro XV Ultrasound Imaging System
- Where
- 10 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Rivanna Medical, Inc.
Pain, Procedural, Analgesia
Procedural Sedation and Analgesia for Treatment of Adults With Fractures and Dislocations in the Emergency Department
The goal of this observational study is to evaluate the effectiveness and safety of different procedural sedation and analgesia methods used for adults with painful fractures requiring reduction treatment in the emergency…
- Conditions
- Pain, Procedural, Analgesia, Extremity Injury, Patient Satisfaction
- Trial name
- PAINEX (NCT07314450)
- Testing
- Usual Care
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Region Zealand
Arthropathy of Knee, Arthropathy of Hip
Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery
The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery.
- Conditions
- Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
- Trial name
- NCT05381818
- Testing
- Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
Lower Extremity Fracture
Perioperative Nutrition Optimization for Reducing Complications After Surgical Fracture Fixation
The objective of this multi-center, prospective, placebo-controlled, randomized study is to compare oral conditionally essential amino acid (CEAA) supplementation for decreasing the key postoperative complications of…
- Trial name
- NCT07155447
- Testing
- CEAA supplementation
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Fracture Healing, Tibial Fractures
Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Tibial Shaft Fractures
The goal of this clinical trial is to learn whether personalized weight-bearing prescriptions using Smart Crutch Tips™ can improve recovery after surgery for tibial shaft fractures.
- Trial name
- NCT07092579
- Testing
- Smart Crutch Tips™, Finite Element Analysis (FEA), Iterative walking
- Where
- 18 sites in Ukraine
- Volunteers
- 30 people
- Sponsor
- Comeback Mobility Inc
Pediatric Patients, Orthopedic Surgery
Nociception Level Index as a Verbal Tool of Pain in Children
60 children under 6 years old, scheduled for orthopedic surgery for limb fracture or neuromuscular and bone deformities will be randomized by closed envelope method into two groups (n=30) either receiving standard pain management…
- Conditions
- Pediatric Patients, Orthopedic Surgery, Extremity Fractures Lower, Extremity Fractures Upper
- Trial name
- NCT05716243
- Testing
- The nociception level index monitorization, The nociception level index measurement;postoperative
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Surgical Site Infection
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF)…
- Trial name
- POTENT (NCT05763602)
- Testing
- povidone-iodine topical ointment
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Loreen Herwaldt
Lower Extremity Fracture, Surgical Fracture Repair
Pre-Incision Peripheral Nerve Blocks for Lower Extremity Fracture Surgery in Older Adults
Fractures of the lower leg are especially difficult for older adults. They are more likely to have serious complications, require longer healing times, and have a higher risk of death This occurs because their bodies cannot…
- Conditions
- Lower Extremity Fracture, Surgical Fracture Repair, Orthopaedic Trauma, Orthogeriatric Fractures
- Trial name
- NCT07217626
- Testing
- Local anesthesia injections
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Maryland, Baltimore
Lower Limb; Fusion, Congenital, Lower Limb Fracture
Investigating Auto Adjusting Dynamic AFO
Offloading Ankle Foot Orthoses (AFOs) are devices designed for people following lower-limb reconstruction to restore mobility by reducing mechanical loading through the injury site and redistributing it proximally.
- Conditions
- Lower Limb; Fusion, Congenital, Lower Limb Fracture, Ankle Foot Injury
- Trial name
- NCT04623853
- Testing
- Variable Stiffness AFO
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Washington
Patients With Fractures
Osteogenon in Orthopedics and Traumatology
The aim of this study was to evaluate the supportive effect of the ossein-hydroxyapatite complex in fracture healing. The investigators hypothesized that the ossein-hydroxyapatite complex would positively impact fracture healing…
- Trial name
- Osteogenon (NCT07210281)
- Testing
- received an ossein-hydroxyapatite complex
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- University of Opole
Ceserean Section, Lower Limb Fractures
Infection Prevention for "Bellwether" Surgery in Ethiopia
The study examines surgical site infections and antimicrobial resistance following life-saving surgeries like C-sections and leg fracture repairs in Ethiopia.
- Conditions
- Ceserean Section, Lower Limb Fractures, Surgical Site Infection (SSI)
- Trial name
- NCT07647796
- Testing
- Surgical Site Infection Prevention and Control (IPC) Bundle
- Where
- Ethiopia
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT07828613)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 31 sites in United States
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Lower Extremity Fracture
Suture Versus Staples for Wound Closure in Orthopaedic Trauma Surgery
This pilot study is designed to assess the feasibility of comparing skin closure methods - sutures versus staples - and subsequent rates of surgical site infection following open reduction and internal fixation surgery for…
- Trial name
- SvS (NCT06586814)
- Testing
- Suture, Staple
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Lower Limb; Sprain (Strain), Lower Limb Fracture
Implementation of an App-based Walking Aid Skills Training Program
Walking aids (WA), such as crutches, canes, and walkers allow individuals to move independently after lower body impairment. Improper WA use may lead to upper body discomfort, pain, or injury.
- Conditions
- Lower Limb; Sprain (Strain), Lower Limb Fracture, Stroke, Multiple Sclerosis
- Trial name
- NCT05347875
- Testing
- Walking aid skills app, Breathing skills app
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Smoking, Tibia Fracture
Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing
The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic…
- Trial name
- NCT05859451
- Testing
- Tobacco Heating System (THS), Smoking abstinence
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Lower Limb Fracture
Prognostic Value of Preoperative Frailty Assessment in Geriatric Lower Limb Orthopedic Surgery
This retrospective study evaluates the effectiveness of frailty assessment tools-specifically the Risk Analysis Index (RAI) and the 5-Item Modified Frailty Index (5-mFI)-in predicting postoperative outcomes for elderly patients…
- Trial name
- NCT07422025
- Testing
- Preoperative Frailty Scoring
- Where
- Egypt
- Volunteers
- 149 people
- Sponsor
- Benha University
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage in Severe Lower Extremity Trauma
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT06293469)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Lower Extremity Fractures
Feasibility of Structured Resistance Training After Lower Extremity Fracture
Adults recovering from surgically managed diaphyseal femur or tibia fractures often experience persistent weakness, pain, and functional limitations despite successful fracture healing.
- Trial name
- NCT07629180
- Testing
- Structured Supervised Resistance Training and Coaching Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's