Clinical trials: Bronchoalveolar Lavage Fluid
Acute Lung Injury
Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury
The exosomes in the experimental group and the control group were sequenced to find the difference of the two groups, providing a basis for subsequent basic research.
- Trial name
- NCT05058768
- Testing
- The lungs causes and extrapulmonary factors
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
ARDS, Human, Aspiration Pneumonia
Potential Biomarkers and Pathogenic Mechanism for Reflux Aspiration-induced Lung Injury.
There is limited research on aspiration pneumonia-induced ARDS (Acute Respiratory Distress Syndrome), and currently there is a lack of studies on corresponding biomarkers and pathogenic mechanisms.
- Trial name
- NCT06164639
- Testing
- aspiration, bronchial alveolar fluid, EIT V/Q test
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Infection
Massively Parallel Sequencing to Identify Microbiological Organisms in Bronchoalveolar Lavage Fluid
Patients who are post hematopoietic stem cell transplantation who require a bronchoalveolar lavage (BAL) for standard clinical car will have extra fluid collected and sent for massively parallel sequencing to see if it is as…
- Trial name
- NCT03995030
- Testing
- massively paralleled sequencing
- Volunteers
- 10 people
- Sponsor
- New York Medical College
Healthy
Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects
This is a Phase 1, multiple dose, open-label pharmacokinetic study conducted in healthy adult male and female subjects to determine and compare plasma, epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations of…
- Trial name
- NCT03303924
- Testing
- ETX2514 and sulbactam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Entasis Therapeutics
Invasive Fungal Disease, Lung Transplant Recipients
Assessing Diagnostic Methods for Invasive Fungal Disease in Lung Transplant Recipients
This study aims to assess the diagnostic performance of different tests, including metagenomic next-generation sequencing (mNGS), real-time PCR, galactomannan assay, and lateral-flow device tests, in detecting invasive fungal…
- Conditions
- Invasive Fungal Disease, Lung Transplant Recipients, Invasive Pulmonary Aspergillosis, Pneumocystis Jirovecii Pneumonia
- Trial name
- NCT06654076
- Volunteers
- 109 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Healthy Volunteers
Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers
To evaluate the intrapulmonary pharmacokinetics (PK), including epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations, of SPR206 as well as plasma concentrations of SPR206 in healthy adult volunteers.
- Trial name
- NCT04868292
- Testing
- SPR206
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL)
BAL Fluid Biomarkers in Sarcoma
This is a single-centre, Phase II, prospective study designed to assess BALF and TA-derived biomarkers in relation to metastatic burden in STS patients.
- Conditions
- Soft Tissue Sarcoma (STS), Bronchoalveolar Lavage (BAL), Bronchoalveolar Lavage Fluid
- Trial name
- NCT06815666
- Testing
- Bronchoscopy & Metastasectomy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
COVID-19 Pneumonia
Multiparametric Assessment of Peripheral Blood and Tissue Myeloid Cells. Phenotype for Precision Medicine in Patients With SARS-Cov-2 Infection
We hypothesise that patients with SARS-Cov-2 infection are characterized by progressive changes in distribution of distinct lung macrophages populations mediated by influx of circulating monocytes into the lungs .
- Trial name
- NCT05767853
- Testing
- Immune-phenotyping of tissue and peripheral blood myeloid compartment
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS