Clinical trials: Bronchopulmonary Dysplasia
Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia
Relationship Between EIT and Respiratory Status in Very Preterm Infants
Electrical Impedance Tomography (EIT) is a non-invasive imaging technique that can measure lung function in real time. This study will follow premature infants to see if EIT can help predict which infants will be successful in…
- Conditions
- Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia, Premature Lungs
- Trial name
- NCT06609135
- Testing
- Sentec LuMon Device (EIT system), Sentec Digital Monitoring System (transcutaneous CO2 monitor)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lawrence Rhein
Premature Birth, Bronchopulmonary Dysplasia
Assessment of Lung Structure and Function of Infants Born Prematurely
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
- Conditions
- Premature Birth, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00422305
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bronchopulmonary Dysplasia
Effect of Synchronized vs. Continuous HFNC Using NAVA on WOB in Infants With BPD
Patients will be randomized to begin the study with either NAVA-synchronized or continuous HFNC. Each patient will receive two 15-minute trials at different levels of continuous HFNC and two 15-minute trials at corresponding…
- Trial name
- NCT04274192
- Testing
- Synchronized HFNC at 6 liters per minute (LPM), Continuous HFNC at 6 liters per minute (LPM), Synchronized HFNC at 8 liters per minute (LPM)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant
Budesonide With Intratracheal Surfactants in Extremely Preterm Infants
This is a phase I/II trial in preterm infants aimed at identifying the optimal dose of budesonide with bovine lipid extract surfactant as vehicle for intratracheal administration.
- Trial name
- BITS (NCT04019106)
- Testing
- Budesonide in bovine lipid extract surfactant (BLES)
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Bronchopulmonary Dysplasia
Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis
The purpose of this study is to determine of clarithromycin effect on developing of bronchopulmonary dysplasia in preterm babies.
- Trial name
- Claprum (NCT01652118)
- Testing
- clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Prematurity; Extreme, Inflammation
Anakinra for Preterm Infants Pilot
Phase I/II study of anakinra to prevent the impact of perinatal inflammation in extremely premature infants.
- Trial name
- NCT05280340
- Testing
- Anakinra
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 25 people
- Sponsor
- Monash Medical Centre
Bronchopulmonary Dysplasia
Lung Ultrasound Score for Early Prediction of Bronchopulmonary Dysplasia in Preterm Newborns
Bronchopulmonary dysplasia (BPD) is one of the most common and severe complications of extreme prematurity, affecting approximately 40% of infants born before 28 weeks of gestation.
- Trial name
- LUS_BPD (NCT07633184)
- Testing
- Lung ultrasound at 7 (±1) days of life, Lung ultrasound at 14 (±2) days of life
- Where
- 4 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Infant, Premature, Diseases, Bronchopulmonary Dysplasia
A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams
The purpose of this study is to compare two methods of delivering Nasal Continuous Airway Pressure (NCPAP): Biphasic Mode and a continuous mode, to see which is better in getting babies off the ventilator and decreasing lung…
- Conditions
- Infant, Premature, Diseases, Bronchopulmonary Dysplasia, Apnea of Prematurity
- Trial name
- NCT00308789
- Testing
- Biphasic Infant flow NCPAP, CPAP
- Where
- Canada
- Volunteers
- 136 people
- Sponsor
- Mount Sinai Hospital, Canada
Infant,Premature, Bronchopulmonary Dysplasia
Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia
Multiple factors contribute to growth failure in infants with BPD, including poor nutrient stores, inadequate intake, increased losses, and increased needs.
- Conditions
- Infant,Premature, Bronchopulmonary Dysplasia, Growth Failure
- Trial name
- NCT03532555
- Testing
- Zinc Acetate, No supplemental zinc
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Utah
Bronchopulmonary Dysplasia, BPD
Follow-up Study of Safety and Efficacy in Subjects Who Completed PNEUMOSTEM® Phase II (MP-CR-012) Clinical Trial
This is a follow-up study to investigate the long-term safety and efficacy of PNEUMOSTEM® versus placebo, for the treatment of BPD in premature infants.
- Trial name
- NCT04003857
- Testing
- PNEUMOSTEM®, normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Medipost Co Ltd.
Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)
Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?
The goal of this study is to determine if giving a steroid medication (specifically, betamethasone) after birth can help extremely premature babies (born before 28 weeks) come off breathing machines safely and reduce their risk…
- Trial name
- NCT07447739
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Khang Nguyen
Preterm Infant, BPD - Bronchopulmonary Dysplasia
Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA
Extubation failure is a significant problem in preterm neonates and prolonged intubation is a well-documented risk factor for development of chronic lung disease.
- Conditions
- Preterm Infant, BPD - Bronchopulmonary Dysplasia, Barotrauma
- Trial name
- NCT03242057
- Testing
- NAVA, NIPPV
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Infantile Respiratory Distress Syndrome, Ventilator Lung; Newborn
Automatic Oxygen Control (SPOC) in Preterm Infants
Single-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (continous positive airway pressure (CPAP) or…
- Trial name
- optimalSPOC (NCT03785899)
- Testing
- SPOCnew, 8s SpO2 averaging, SPOCold
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Tuebingen
Ureaplasma Infections
Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants
The purpose of this study is to determine whether intravenous azithromycin is effective in eradicating Ureaplasma respiratory tract infection in preterm infants born at 24 to 28 weeks gestation.
- Trial name
- AZIPIII (NCT01778634)
- Testing
- Azithromycin
- Where
- 7 sites in United States
- Volunteers
- 121 people
- Sponsor
- University of Maryland, Baltimore
Bronchopulmonary Dysplasia, Healthy
Impact of an Exercise Program for Children Aged 4 to 6 Years With Bronchopulmonary Dysplasia
The purpose of this study is to determine the effects of a physical activity program for children with Bronchopulmonary Dysplasia.
- Trial name
- NCT02523521
- Testing
- Physical activity program
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hospital de Nens de Barcelona
Bronchopulmonary Dysplasia
Respiratory Oscillometry for the Prediction of Bronchopulmonary Dysplasia
The goal of this observational study is to learn about the correlation between respiratory system reactance, as assessed by respiratory oscillometry, and respiratory outcomes in preterm infants born before 32 weeks of gestation.
- Trial name
- REACT (NCT05986032)
- Testing
- Respiratory Oscillometry
- Where
- 6 sites in Austria, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Bronchopulmonary Dysplasia, Lung Diseases
High Frequency Ventilation in Premature Infants (HIFI)
To compare the efficacy and safety of high frequency ventilation (HFV) with that of standard, mechanical ventilation in premature infants of less than 2000 grams.
- Conditions
- Bronchopulmonary Dysplasia, Lung Diseases, Respiratory Distress Syndrome
- Trial name
- NCT00000567
- Testing
- high-frequency ventilation
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bronchopulmonary Dysplasia
Nasal Mask and Prong Use in Non-invasive Ventilation for Newborns
The study aims to investigate efficacy and safety of nasal mask and prongs used in non-invasive ventilation in newborns by using esophageal pressure transducer.
- Trial name
- NIV (NCT01989442)
- Testing
- binasal prongs, nasal mask
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara University
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
Bronchopulmonary Displasia
Investigation of Polymorphisms in Bronchopulmonary Dysplasia In Turkish Population
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects a ratio of up to 20-30% of infants prematurely born before 30rd week.
- Trial name
- NCT03467828
- Testing
- polymorphism analyzing
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Seda Yilmaz Semerci