Clinical trials: Brown Adipose Tissue
Type2 Diabetes
Effects of Fructose/Glucose-rich Diet on Brown Fat in Healthy Subjects (GB7)
Activating brown and beige adipose tissue (herein described as BAT) has been recently recognized as a potential means to increase energy expenditure and lower blood glucose, however, BAT activity appears to be reduced with…
- Trial name
- GB7 (NCT03188835)
- Testing
- Diet, cold exposure, 18FDG
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Polycystic Ovary Syndrome (PCOS)
Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07896642
- Testing
- inositol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Adipose Tissue, Brown, Glucose Intolerance
L-arginine and Brown Adipose Tissue
The South Asian population is facing an epidemic of type 2 diabetes, of which the underlying cause is still unknown. It is currently hypothesized that an ethnic susceptibility towards a disturbed energy metabolism may underlie…
- Conditions
- Adipose Tissue, Brown, Glucose Intolerance, Nitric Oxide
- Trial name
- ArgMB (NCT02291458)
- Testing
- L-arginine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
HIV Infections
HIV Fat Redistribution and the Evaluation of Brown Fat
The specific aims of this study are to determine whether HIV-infected patients with significant fat redistribution and ectopic fat accumulation have increased brown adipose tissue using 18F-FDG Positron Emission Tomography…
- Trial name
- NCT01098045
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Menopause, Obesity
Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is…
- Trial name
- NCT02927392
- Testing
- Leuprolide acetate
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Lifestyle
BATokines as Biomarkers of Brown Fat in Humans
Brown adipose tissue (BAT) burns excess calories to produce heat in response to environmental cold. Rapidly growing evidence from rodent and human studies suggests that the presence and activation of brown fat are far more…
- Trial name
- NCT05050240
- Testing
- Cooling Vest Procedure, Fasting overnight
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity
Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI.
- Trial name
- NCT02220426
- Testing
- Xenon
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adiposity, Metabolic Complication
Insight Into New Brown Adipose Tissue Activators.
The general purpose of the study was to provide new information about the role of macronutrients intake, metabolomics, proteomics and microRNA on BAT activation.
- Conditions
- Adiposity, Metabolic Complication, Metabolic Disturbance, Healthy
- Trial name
- NCT04787952
- Testing
- cold expossure
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Obesity, Diabetes
A Role for Brown Adipose Tissue in Postprandial Thermogenesis?
Brown adipose (fat) tissue (BAT) is a type of fat tissue found in certain small rodents and human babies that is capable of extremely high rates of energy burning.
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT01974778
- Testing
- Meal
- Where
- Australia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity
Fasting Mimicking Diet and Beige/Brown Adipose Tissue in Humans
Obesity today has become one of the main public health concerns. As a consequence, different strategies have arisen to fight weight gain.
- Trial name
- NCT04385615
- Testing
- Fasting Mimicking Diet
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Thermogenesis
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator of brown adipose tissue, a…
- Trial name
- ASCENT (NCT05294965)
- Testing
- Fenoterol, Mild cold exposure
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Type 2 Diabetes
Activation of Brown Adipose Tissue Metabolism Using Mirabegron
Could sympathomimetics and sympatholytics drugs safe for the management of Type 2 Diabetes (T2D)? Based on recent evidence, we propose that pharmacological stimulation of Beta-3 adrenergic receptor (ADBR3) at higher doses of…
- Trial name
- GB9 (NCT04823442)
- Testing
- Mirabegron, Bisoprolol Fumarate
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes
Brown Adipose Tissue Metabolism in Type 2 Diabetes
Activation of brown adipose tissue (BAT) by cold exposure. BAT thermogenesis and BAT volume of metabolic activity will be assessed by Positron-Emitting-Tomography (PET/CT) and MRI/MRS imaging and new pharmacological methods to…
- Trial name
- GB8 (NCT05092945)
- Testing
- Cold exposure, Oral Nicotinic acid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy
Circadian Brown Adipose Tissue Metabolism
Brown adipose tissue is poorly understood fat that can metabolize glucose in order to generate heat. Since activated brown fat has a high metabolic rate, it is of great interest as a potential target to combat obesity.
- Trial name
- NCT02285270
- Testing
- FDG PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Caffeine-Induced Thermogenesis, Brown Adipose Tissue Activation
Caffeine-Induced Thermogenesis Assessed by Infrared Thermography
This study evaluated thermogenic and physiological responses to 200 mg of caffeine administered following a carbohydrate gel in healthy adults.
- Trial name
- NCT07868302
- Testing
- Carbohydrate Gel, Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Obesity
CB1 Receptors in Human Brown Adipose Tissue
This study investigates cannabinoid CB1 receptors in human brown adipose tissue (BAT) and other tissues using positron emission tomography (PET) imaging.
- Trial name
- CANBAT (NCT02941172)
- Testing
- Cold exposure, [18F]FMPEP-d2, [18F]FDG
- Where
- Finland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Resting Energy Expenditure, Thermogenesis
MIrabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT05990387
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity
Effects of b3-Adrenergic Receptor Agonists on Brown Adipose Tissue
This study will test the hypothesis that human brown adipose tissue (BAT) can be activated using a β3-adrenergic receptor (AR) agonist.
- Trial name
- NCT01783470
- Testing
- beta3-adrenergic receptor agonist
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aaron Cypess
Cardiometabolic Diseases, Postmenopause
Exercise and Prolonged Fasting to Improve Brown Adipose Tissue Function in Postmenopausal Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate mitochondrial function in interscapular brown adipose tissue (iBAT) in postmenopausal women and determine whether aerobic exercise, prolonged…
- Trial name
- EMPOWER-BAT (NCT07837752)
- Testing
- Aerobic exercise, Prolonged fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria