Clinical trials: Bupivacaine
Equivalent Concentrations, Different Volumes
Different Volumes and Equivalent Concentrations of Bupivacaine in Erector Spinae Plane Block in Modified Radical Mastectomy
This study aimed to compare and evaluate the efficiency of different volumes and equivalent concentrations of bupivacaine in erector spinae plane block in reducing the Postoperative pain after modified radical mastectomy.
- Conditions
- Equivalent Concentrations, Different Volumes, Bupivacaine, Erector Spinae Plane Block
- Trial name
- NCT07872371
- Testing
- Erector spinae plane block with 10 ml of 0.25% isobaric bupivacaine, Erector spinae plane block with 20 ml of 0.25% isobaric bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Total Knee Anthroplasty, Nerve Block
Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty
Effective postoperative pain management remains a cornerstone of enhanced recovery protocols following total knee arthroplasty (TKA).
- Conditions
- Total Knee Anthroplasty, Nerve Block, Ropivacaine, Liposomal Bupivacaine
- Trial name
- NCT07509866
- Testing
- Liposomal bupivacaine (LB), Ropivacaine with Perineural Dexamethasone, Ropivacaine with Perineural Dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Huazhong University of Science and Technology
Thyroidectomy, Bupivacaine
Ketamine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound Guided Bilateral Superficial Cervical Plexus Block in Thyroidectomy
The aim of this study is to compare the analgesic efficacy of Dexmedetomidine and Ketamine as adjuvants to Bupivacaine in ultrasound-guided Bilateral SCPB in patients undergoing thyroidectomy
- Conditions
- Thyroidectomy, Bupivacaine, Dexmedetomidine
- Trial name
- NCT07838831
- Testing
- Group C (Control group), Group D (Dexmedetomidine group), Group K (Ketamine group)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Morphine, Dexmedetomidine
Morphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in TAP Block in Lower Abdominal Surgeries
This study aimed to ascertain the safety and efficacy of dexmedetomidine in comparison to morphine as adjuvants to bupivacaine during transversus abdominis plane (TAP) block in postoperative pain management in adult patients…
- Conditions
- Morphine, Dexmedetomidine, Adjuvants, Bupivacaine
- Trial name
- NCT07842861
- Testing
- Transversus abdominis plane block + Dexmedetomidine, Morphine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Fentanyl, Dexmedetomidine
Fentanyl Vs Dexmedetomidine as Adjuvants to Bupivacaine in Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Arthroscopic Shoulder Surgeries
This study aimed to evaluate the effect of fentanyl versus dexmedetomidine as adjuvants to bupivacaine with comparison to bupivacaine alone in ultrasound-guided erector spinae plane block on the quality and duration of pain…
- Conditions
- Fentanyl, Dexmedetomidine, Bupivacaine, Erector Spinae Plane Block
- Trial name
- NCT07836595
- Testing
- Bupivacaine 0.25%, Bupivacaine 0.25% + Fentanyl 1µg/kg, Bupivacaine 0.25% + dexmedetomidine 1µg/kg
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Optimal Volume of Liposomal Bupivacaine
Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery
Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB.
- Trial name
- NCT06942689
- Testing
- Perform adductor canal block with liposomal bupivacaine.
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Parotid Neoplasm, Bupivacaine
Clinical Tolerance of an Intraparotid Injection of Bupivacaine, Combined With Dexamethasone, After Parotidectomy for Benign Tumor
There has been a paradigm shift toward less invasive surgical techniques for parotidectomies, primarily to mitigate post-surgical complications.
- Conditions
- Parotid Neoplasm, Bupivacaine, Dexamethasone
- Trial name
- PAROCAINE (NCT07812259)
- Testing
- Intraparotid injection of bupivacaine/ dexamethasone
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pain, Postoperative, Liposomal Bupivacaine
Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain
The supraclavicular brachial plexus block (BPB) is a frequently used anaesthetic method for upper limb surgeries, including distal radial fracture surgery.
- Conditions
- Pain, Postoperative, Liposomal Bupivacaine, Dexamethasone, Supraclavicular Brachial Plexus Block
- Trial name
- NCT07665762
- Testing
- 10ml 0.5% plain bupivacaine with 10ml 1.33% liposomal bupivacaine, 19ml 0.5% plain bupivacaine with 1ml (4mg) dexamethasone
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Abdominal Laparoscopic and/or Robotic Surgery, Local Anasthesia
Intraperitoneal Lidocaine and Bupivacaine for Postoperative Pain After Laparoscopic Surgery
The goal of this clinical trial is to determine the safety and efficacy of combined intraperitoneal local anesthetic instillation and port-site infiltration using lidocaine and bupivacaine in adults aged 18 to 60 undergoing…
- Conditions
- Abdominal Laparoscopic and/or Robotic Surgery, Local Anasthesia, Post Operative Pain, Acute, Lidocaine
- Trial name
- IPLA (NCT07775599)
- Testing
- Lidocaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Misr University for Science and Technology
Total Dose of Bupivacaine Administered During Labor
Dexmedetomidine as an Adjuvant During Dural Puncture Epidural
The study aimed to determine the effects of using varied doses of DEX on the concentration of bupivacaine injected for epidural labor analgesia, and to assess the benefits of the dural puncture epidural.
- Trial name
- NCT07506044
- Testing
- Epidural Catheter with bupivacaine, Epidural with dural puncture, Dexmedetomidine 0.4 added
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Menoufia University
Pain, Interscalene Blocks
Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Block.
Recent studies have highlighted the comparative advantages of perineural dexamethasone, particularly regarding its safety profile and its ability to prolong analgesia in various peripheral nerve blocks.
- Conditions
- Pain, Interscalene Blocks, Dexamethasone, Bupivacaine
- Trial name
- NCT07324499
- Testing
- administration of dexamethasone intravenously
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Fascia Iliaca Block, Liposomal Bupivacaine
Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery
Patients after hip surgery often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications.
- Conditions
- Fascia Iliaca Block, Liposomal Bupivacaine, Postoperative Pain, Hip Surgery
- Trial name
- NCT07643792
- Testing
- Liposomal bupivacaine (LB), Plain bupivacaine
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Peking University First Hospital
Liposomal Bupivacaine
Exparel Versus Bupivacaine in Post-operative Pain Control
This is a prospective, randomized study to evaluate anaesthetic parameters, postoperative analgesia and oral analgesic consumption comparing exparel (liposomal bupivacaine) vs. standard bupivacaine
- Trial name
- NCT06547255
- Testing
- Bupivacaine liposome injectable suspension
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Liposomal Bupivacaine, Preperitoneal Infiltration
Liposomal Bupivacaine Versus Ropivacaine for Preperitoneal Infiltration Analgesia in Upper Abdominal Laparotomy
Upper abdominal open surgery is associated with significant trauma, and postoperative pain management poses considerable challenges.
- Conditions
- Liposomal Bupivacaine, Preperitoneal Infiltration, Analgesia
- Trial name
- NCT07271979
- Testing
- Liposomal bupivacaine, ropivacaine
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Qilu Hospital of Shandong University
Video-assisted Thoracoscopic Surgery (VATS), Pain Management
The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy. It is reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine, Local Injection
- Trial name
- NCT07432711
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia, Spinal, Orthopedic Procedures
Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia
The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly…
- Conditions
- Anesthesia, Spinal, Orthopedic Procedures, Postoperative Recovery in Elderly Patients, Hemodynamics
- Trial name
- NCT07684989
- Testing
- Low-Dose Hyperbaric Bupivacaine, Standard-Dose Hyperbaric Bupivacaine
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Mayo Hospital Lahore
Bupivacaine, Ultrasound-Guided
Bupivacaine Liposomes or Bupivacaine for CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery
Numerous studies have confirmed that regional analgesia using peripheral nerve block has great potential for perioperative analgesia in abdominal surgery.
- Conditions
- Bupivacaine, Ultrasound-Guided, Analgesia, Postoperative, Opioids
- Trial name
- NCT06737341
- Testing
- Bupivacaine Liposomes(BL), Bupivacaine(B)
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Huazhong University of Science and Technology
Liposome Bupivacaine, Erector Spinae Plane Block
The Effect of Liposomal Bupivacaine Erector Spinae Plane Block
This is a single-center, randomized, controlled, double-blind clinical trial. A total of 148 patients undergoing elective open upper abdominal surgery will be included and randomly assigned 1:1 to receive ultrasound-guided…
- Conditions
- Liposome Bupivacaine, Erector Spinae Plane Block, Postoperative Analgesia, Randomized Controlled Trial
- Trial name
- NCT07667439
- Testing
- Liposomal bupivacaine plus bupivacaine hydrochloride, Bupivacaine hydrochloride monotherapy
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rebound Pain, Liposomal Bupivacaine
Comparison of Liposomal Bupivacaine Versus Ropivacaine in Alleviating Rebound Pain
Shoulder arthroscopy is a frequently performed orthopedic procedure used to address various issues like rotator cuff tears, instability, and stiffness.
- Trial name
- NCT07196631
- Testing
- Liposomal Bupivicaine, ropivacaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Liu Jiuhong
Intrathecal Injection, Hyperbaric Prilocaine
Intrathecal Injection of Hyperbaric Prilocaine Versus Hyperbaric Bupivacaine for Cystoscopic Procedures
This study aims to compare the intrathecal injection of hyperbaric prilocaine 2% versus hyperbaric bupivacaine 0.5% in cystoscopy procedures.
- Conditions
- Intrathecal Injection, Hyperbaric Prilocaine, Hyperbaric Bupivacaine, Cystoscopic Procedures
- Trial name
- NCT07664618
- Testing
- Bupivacaine, Prilocaine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University