Clinical trials: Bupivacaine
Pain, Postoperative
Trial of Liposomal Versus Plain Bupivacaine in Minimally Invasive General Surgery Procedures
Aim: To compare the postoperative outcomes after surgical infiltration with plain bupivacaine compared to liposomal bupivacaine in patients undergoing elective, minimally invasive, general surgery procedures.
- Trial name
- NCT02875288
- Testing
- liposomal bupivicaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Cesarean Section Complications
Intrathecal Bupivacaine-fentanyl and Bupivacaine-dexmedetomidine for Elective Low Segment Caesarean Section
the primary objective of the study is to compare the onset and recovery times of sensory and motor blockade of the two study drugs intrathecally with low dose bupivacaine The secondary objectives of the study are to observe…
- Trial name
- NCT04095013
- Testing
- Bupivacaine, fentanyl, Bupivacaine, dexmedetomidine
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Dexmedetomidine
Bupivacaine Alone vs Bupivacaine and Dexmed in Cesarean Deliveries
The purpose of the study is to compare the onset and duration of sensory and motor block after spinal anesthesia between intrathecal bupivacaine alone vs intrathecal bupivacaine and dexmedetomidine combination.
- Trial name
- NCT05469529
- Testing
- Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KRL Hospital, Islamabad
Post Operative Pain
Comparison of Exparel to Marcaine in Post-Surgical Analgesia in Bariatrics
This study is designed to evaluate the use of bupivacaine liposome 1.3% compared bupivacaine 0.5% in pain control in post-operative laparoscopic bariatric surgery patient The purpose of this study is to evaluate two local…
- Trial name
- NCT02752230
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Sleeve Gastrectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kettering Health Network
Pain, Postoperative
Comparison Between Two Different Doses of Nulbuphine _bupivacaine in TAP Block in Cancer Abdominal Surgeries
To compare the analgesic effect of two different doses of nulbuphine (10 mg and 20 mg) added to bupivacaine in bilateral subcostal single injection in ultrasound-guided TAP block for abdominal surgeries.
- Trial name
- NCT05090579
- Testing
- Group I (BN10), Active Comparator:Group ll (BN20), Active Comparator:Group lll (B)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hand Surgery, Wrist Surgery
The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control.
- Conditions
- Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation
- Trial name
- NCT06806410
- Testing
- Liposomal bupivacaine (LB), Dexamethasone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Comparing the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section
one of the most common complications associated with spinal anesthesia is hypotension, which can have adverse effects on both the mother and the fetus.
- Trial name
- NCT06290583
- Testing
- Bupivacaine, Prilocaine
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- South Valley University
Knee, Arthroscopy
Analgesic Control Following Knee Arthroscopy
This study aims to investigate the analgesic effects offered by bupivacaine and Durolane (a hyaluronic acid supplement) administered immediately following the completion of knee arthroscopy.
- Conditions
- Knee, Arthroscopy, Analgesia
- Trial name
- NCT01169389
- Testing
- Intraarticular injection, Intra-articular injection of 0.5% Bupivacaine
- Where
- Ireland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Research and Innovation Foundation, Ireland
Pain
The Use of Liposomal Bupivacaine in TAP Blocks for Women Undergoing Cesarean Section
This present investigation aims to determine whether a transversus abdominous plane(TAP) block, utilizing liposomal bupivacaine (Exparel), at the conclusion of a cesarean section decreases post-operative pain.
- Trial name
- NCT02847013
- Testing
- TAP block w Liposomal bupivacaine, TAP block w normal saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Milk Expression, Breast
Exparel PK and Breast Milk Excretion
Investigate the pharmacokinetics of Liposomal Bupivacaine and its excretion in breast milk in patients undergoing TAP block after their scheduled C -section delivery
- Trial name
- NCT03526419
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain, Postoperative
Liposomal Bupivacaine Versus Interscalene Nerve Block
The aim of this study is to compare two different pain management interventions in patients undergoing reverse total shoulder arthroplasty.
- Trial name
- NCT03929146
- Testing
- Exparel, Interscalene Nerve Block
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anesthesia, Spinal
Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery
The following obstetric procedures are commonly performed with spinal anesthesia on labor and delivery: bilateral tubal ligation, external cephalic version, cerclage insertion, cerclage removal, minimally invasive fetal surgery…
- Trial name
- CLIMB (NCT03967288)
- Testing
- Chloroprocaine Injection [Clorotekal], Bupivacaine Hydrochloride 0.75% Injection Solution
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pain, Acute
Intrathecal Midazolam, Fentanyl and Nalbuphine as Adjuvants to Bupivacaine in Spinal Anesthesia for Cesarean Section
The main limitations of spinal anesthesia are its short duration of action and do not provide prolonged postoperative analgesia when it is performed only with local anesthetics.
- Trial name
- NCT04932083
- Testing
- Bupivacaine, Fentanyl, Nalbuphine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benha University
Dexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
Evaluation of the Analgesic Effect of Dexmedetomidine Versus Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
To determine if the epidural route provide an acceptable analgesia in spine surgeries and avoided the need for excessive IV analgesics.
- Trial name
- NCT03463083
- Testing
- Dexmedetomidine, Bupivacaine, Fentanyl
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Obstetric
Efficacy of Extended-Release Liposomal Bupivacaine for Post-Partum Pain Management Following Obstetrical Laceration
We propose a prospective, randomized, single blinded trial with subjects recruited from the WRNMMC Labor and Delivery Unit to study post-partum efficacy of Exparel® for pain control in patients undergoing a vaginal delivery who…
- Trial name
- NCT03152877
- Testing
- Bupivacaine Liposome Injectable Product, 0.25% plain bupivacaine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Pain, Postoperative
Analgesic Efficacy of Two Adjuvants During Spinal Anaesthesia.
: Pain modulation is very important after operation, particularly for women who undergo caesarean section. A pain-free postoperative period is essential following a caesarean section so new mothers may care for and bond with…
- Trial name
- NCT03458078
- Testing
- Saline Solution, Magnesium Sulfate, Midazolam 5 MG/ML Injection
- Where
- 2 sites in Tunisia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre de Maternité de Monastir
Injuries, Hand, Anesthesia Conduction
Cardiovascular Safety Research: Bupivacaine With Vasoconstrictor Versus Ropivacaine in Brachial Plexus Block
The purpose of this study is to determine if bupivacaine (75% levobupivacaine plus 25% racemic bupivacaine) with vasoconstrictor is effective and safety as ropivacaine in brachial plexus block for orthopedic surgery.
- Conditions
- Injuries, Hand, Anesthesia Conduction, Anesthetics, Local
- Trial name
- NCT00523289
- Testing
- Bupivacaine, Ropivacaine
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Onset and Duration of a Digital Nerve Block
Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers
The duration of the autonomic (sympathetic) block will last longer than the sensory block. The duration of the increased perfusion index will last longer than either the sympathetic or sensory block.
- Trial name
- NCT01508832
- Testing
- Lidocaine Digital Nerve Block, Bupivacaine Digital Block
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Supraclavicular Brachial Plexus Block
Th Effects of a Drug Dexmedotemidine in Regional Anesthesia in Participants Undergoing Upper Limb Surgeries
In this study, we will assess the effect of combined Dexmedetomidine and Bupivacaine analgesia on the onset and duration of anesthesia in supraclavicular plexus block compared to Bupivacaine alone.
- Trial name
- NCT04981951
- Testing
- Dexmedetomidine
- Where
- Palestinian Territories
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zaher Nazzal
Teeth, Impacted
Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction
The third molars are the teeth that are most frequently included and impacted, extraction is one of the most performed treatments by maxillofacial surgeons in their clinical practice.
- Trial name
- NCT03950700
- Testing
- Bupivacaine-epinephrine, Saline Solution
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CES University