Clinical trials: Burn Scar, open to volunteers
Joint Contracture, Contracture
Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft
The purpose of this study is to compare how often joint contractures in the arms and legs come back after two common types of reconstructive surgery: Z-plasty and full-thickness skin graft (FTSG).
- Conditions
- Joint Contracture, Contracture, Cicatrix, Burn Scar Contractures
- Trial name
- NCT07885046
- Testing
- Z-Plasty, Full-Thickness Skin Graft
- Volunteers
- 300 people
- Sponsor
- Universitas Sebelas Maret
Burn Scar, Itch Scarring
Novel Strategies for Reducing Burn Scar Itch
The purpose of the study is to see whether using diphenhydramine (Benadryl), famotidine (Pepcid), and cromolyn sodium will decrease burn scar itch.
- Conditions
- Burn Scar, Itch Scarring, Wound
- Trial name
- NCT06801626
- Testing
- Famotidine and 4% topical cromolyn sodium
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burn Scar, Burn Wound
Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients
The goal of this study is to see how an ingredient called kynurenic acid (which we named "FS2") affects scar formation in people with burn injuries that need skin graft surgery.
- Trial name
- NCT06807021
- Testing
- IP1 control cream (Vehicle base), IP2 - 0.5% w/w FS2
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Birch BioMed Inc
Facial Scarring, Facial Trauma
Tools for Return of Facial Function
This study will evaluate novel intraoral (inside-the-mouth) splints designed to gently stretch facial tissues that have become tight or scarred following facial trauma, including burn injuries and gunshot wounds.
- Conditions
- Facial Scarring, Facial Trauma, Burn, Orofacial Contracture
- Trial name
- NCT07825844
- Testing
- Intraoral Stretching Splints
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burn, Hypertrophic Scars
Carbon Dioxide Laser-Assisted Delivery of Triamcinolone With or Without 5-Fluorouracil for Hypertrophic Burn Scars
Burn scars can sometimes heal in a way that causes them to become thick, raised, and stiff. These scars may itch, feel uncomfortable, limit movement, and affect how the skin looks.
- Conditions
- Burn, Hypertrophic Scars, Scar Improvement by Laser, CO2 Laser in Scars
- Trial name
- NCT07660120
- Testing
- Fractional Ablative CO₂ Laser, Triamcinolone Acetonide, Fluorouracil (5-FU)
- Volunteers
- 65 people
- Sponsor
- University of California, Davis
Burns, Contracture Scar
Autologous Point-of-Care Adipose Therapy: Delayed Injury/Scar
The goal of this study is to explore if an adipose-based therapeutic strategy can treat contracted scars secondary to soft-tissue burn wounds in injured individuals, especially those with severe burns or soft-tissue loss.
- Conditions
- Burns, Contracture Scar, Surgical Injury
- Trial name
- NCT06857435
- Testing
- Full Thickness Skin Graft (FTSG), Base of wound fat graft with Split Thickness Skin Graft (STSG) Reconstruction (Autologous Layered Composite Grafting).
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Burns, Contracture Scar
Autologous Point-of-Care Adipose Therapy: Recent Injury
The goal of this study is to explore if an adipose-based therapeutic strategy can treat full-thickness soft-tissue trauma wounds in injured individuals, especially those with severe burns or soft-tissue loss.
- Conditions
- Burns, Contracture Scar, Surgical Injury
- Trial name
- NCT06857448
- Testing
- Split Thickness Skin Graft (STSG), Base of wound fat graft with STSG Reconstruction (Autologous Layered Composite Grafting).
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of Pittsburgh
Burns, Hypertrophic Scar
Differential Pressure Distribution Orthosis by 3D Printing Process in the Treatment of Post-burn Hypertrophic Scarring
This is a pilot, single-center, feasibility study to evaluate a new 3D printing method for ORDP design. To our knowledge, there is no technical or clinical evaluation of ORDPs, particularly in the treatment of hypertrophic scars.
- Trial name
- EPIDERM (NCT06487910)
- Testing
- 3D scan measurment
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Burn Scar
Scar Management Through Serial Casting
Scar management remains one of the major clinical challenges for burn survivors with hypertrophic scars. Beyond their visible appearance, hypertrophic scars can significantly impair physical function, reduce life satisfaction…
- Trial name
- NCT07645664
- Testing
- Serial casted scar
- Volunteers
- 38 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Scar
The Role of Pulsed Dye Laser Therapy in the Management of Burn Scars
The purpose of this study is to determine the effects (good or bad) of pulsed dye laser treatment in burn scar height, texture, redness and pliability in acute burn injury.
- Trial name
- NCT01488240
- Testing
- pulsed dye laser
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Manitoba
Burn Scar
The Role of Fractional Vascular Laser Therapy in the Management of Burn Scars
While the literature tends to support the use of laser therapy in the management of burn scars, there is a definite lack of appropriately powered, randomized controlled trials.
- Trial name
- NCT01619917
- Testing
- Fractional Vascular Laser
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Manitoba
Hypertrophic Scars, Post-burn Scars
Nano-Fat Grafting for Post-Burn Scars on the Chest, Shoulders, and Back
This study aims to evaluate the effectiveness of nano-fat grafting in treating hypertrophic scars caused by burns on the chest, shoulders, and back.
- Conditions
- Hypertrophic Scars, Post-burn Scars, Burns
- Trial name
- NCT07557472
- Testing
- Autologous Nano-Fat Grafting
- Volunteers
- 55 people
- Sponsor
- Assiut University
Burn Scar
Effect of Pulsed Electromagnetic Field on Pruritus in Burn Scars
This study will be conducted to evaluate the effectiveness of pulsed electromagnetic field therapy in pruritus in patients with burn scars.
- Trial name
- PEM (NCT07443358)
- Testing
- pulsed electromagnetic field therapy, standard care
- Volunteers
- 40 people
- Sponsor
- Cairo University
Burn Scar Pain, Neuropathic Pain
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue.
- Conditions
- Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
- Trial name
- US-SCAR-PAIN (NCT07438769)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Burn Scar, Hypertrophic Scarring
Remimazolam vs Propofol in Laser Burn Cases
This randomized, single-blind, crossover study compares remimazolam and propofol for monitored anesthetic care during fractional ablative CO₂ laser therapy for burn scars.
- Conditions
- Burn Scar, Hypertrophic Scarring, Procedural Sedation
- Trial name
- NCT07213544
- Testing
- Remimazolam besylate, Propofol
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Medical University of South Carolina
Burn, Scar
Paraffin Wax and Exercise Prospective
This study is being done to test if paraffin wax can be used to improve the range of motion and function for scars across joints when used in combination with scar rehabilitation therapy sessions.
- Conditions
- Burn, Scar, Exercise Therapy
- Trial name
- NCT06786884
- Testing
- paraffin wax, standard of care exercise therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Romberg Disease, Craniofacial Microsomia
Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting…
- Conditions
- Romberg Disease, Craniofacial Microsomia, Burn Scar, Post-Traumatic Scar (Disorder)
- Trial name
- NCT05610878
- Testing
- Cultured ASCs enrichment fat grafting, Curcumin-preconditioned ASCs enrichment fat grafting, Conventional fat grafting
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- University of the Punjab
Hypertrophic Scars, Burn Scar Patients
Effect of PRF & Fractional CO2 Laser in Postburn Hypertrophic Scars
Recent advancements in scar management include the use of Plasma Rich Fibrin (PRF) injections and fractional CO2 laser treatments.
- Trial name
- NCT06664268
- Testing
- Plasma rich in growth factors (PRGF-Endoret), Fractional CO2 laser assisted PDT
- Volunteers
- 30 people
- Sponsor
- Assiut University