Clinical trials: CAD
Cardiovascular Diseases, Atherosclerosis
Aspirin Dose and Atherosclerosis in Patients With Heart Disease
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients who have had a heart attack.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Myocardial Infarction
- Trial name
- TAD (NCT00272337)
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Cardiovascular Diseases, Adherence, Medication
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
The study plans to learn if sending different text messages, serving as reminders or encouragement, may help patients take their medication more often if they have had trouble keeping up with their medicines.
- Conditions
- Cardiovascular Diseases, Adherence, Medication, Medication Adherence, Diabetes Mellitus
- Trial name
- NCT03973931
- Testing
- Nudge
- Where
- 4 sites in United States
- Volunteers
- 9,501 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Coronary Artery Disease (CAD), Coronary Artery Calcification
Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)
SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force.
- Conditions
- Coronary Artery Disease (CAD), Coronary Artery Calcification, Occupational Diseases, Aviator's; Disease
- Trial name
- SUSPECT (NCT05508893)
- Testing
- CT Angiography, Exercise stress test
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Coronary Artery Disease
A Study to Assess the Bioavailability of Different Formulations of AZD5718 and the Food Effect on the Selected Formulation of AZD5718 in Healthy Volunteers
In this study, the relative bioavailability of different formulations of AZD5718 will be determined in order to compare it with the formulation used in a previous Phase 2a study and confirm appropriate drug exposure.
- Trial name
- NCT03420092
- Testing
- Form 1 of AZD5718 tablets, Form 2 of AZD5718 tablets, Form 3 of AZD5718 tablets
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Coronary Artery Disease
Evaluation of Diagnostic Accuracy of MCG(Magnetocardiography) Scan in Suspected Coronary Artery Disease
This multicenter clinical trial is designed to evaluate the diagnostic accuracy of MCG scan in detecting significant CAD compared to the reference standard CAG.
- Trial name
- EDAM-CAD (NCT05825911)
- Testing
- Rest/Stress MCG scan, Rest MCG scan
- Where
- 2 sites in South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- AMCG
Healthy, Hypercholesterolemia
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular disease (CVD).
- Conditions
- Healthy, Hypercholesterolemia, Hypertension, Overweight
- Trial name
- NCT06675994
- Testing
- PCSK9 Antibody, PCSK9 Enzyme
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Coronary Disease, Healthy
Study of Blood Flow in Heart Muscle
Blood flows to areas of the heart providing oxygen and fuel to the pumping muscle. Occasionally the arteries providing the fuel can become blocked. This occurs in coronary artery disease.
- Conditions
- Coronary Disease, Healthy, Hypertrophic Cardiomyopathy, Myocardial Ischemia
- Trial name
- NCT00001631
- Testing
- Magnetic resonance imaging
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Evaluation of Respiratory Parameters and Functional Capacity in Coronary Artery Patients
The purpose of this study is to evaluate respiratory parameters and functional capacity in coronary artery patients.
- Trial name
- NCT05549739
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Myocardial Blood Flow Reserve, Mechanical Dyssynchrony
Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT
The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluation of patients with coronary…
- Conditions
- Myocardial Blood Flow Reserve, Mechanical Dyssynchrony, Coronary Arterial Disease (CAD)
- Trial name
- MD&MD (NCT06969547)
- Testing
- dynamic SPECT (two-day rest/stress protocol), gated myocardial perfusion imaging, blood sampling
- Where
- Russia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease
3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.
- Conditions
- Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease, Cardiac Risk Factors, Myocardial Infarction
- Trial name
- NCT05286593
- Testing
- Slow Infusion of Rubidium-82
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Postprandial Dyslipidemia
Relation Between Postprandial Lipogram and Coronary Artery Disease Severity
Coronary artery disease (CAD) is usually used to refer to the pathological problem affecting the coronary arteries (usually atherosclerosis) that leads to Coronary Heart disease (CHD) which includes the diagnoses of angina…
- Trial name
- NCT03175393
- Testing
- coronary angiography
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Artificial Intelligence (AI)
Performance of an OCR-Prompt-LLM Integrated Workflow for Extracting Multi-dimensional Clinical Data in Ischemic Heart Disease
This research aims to evaluate a comprehensive AI-driven workflow for both clinical data extraction and diagnostic classification in coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Artificial Intelligence (AI), Data Collection
- Trial name
- OPAL-CAD (NCT07499830)
- Testing
- OCR-Prompt-LLM Information Extraction Workflow, Manual Clinical Data Review
- Where
- China
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiovascular Diseases, Heart Diseases
Behavioral Factors in Coronary Heart Disease
To elucidate the role of biobehavioral factors in the etiology, pathogenesis and course of coronary heart disease (CHD) and to use this knowledge to devise more effective prevention, treatment and rehabilitation approaches.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Metabolic Syndrome X
- Trial name
- NCT00005314
- Volunteers
- 694 people, healthy volunteers welcome
- Sponsor
- Duke University
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Coronary Atherosclerosis
Premature Coronary Artery Disease in Women - Risk Factors and Prognosis
Cardiovascular risk in women is systematically underestimated by both - society and physicians. Women younger than 50 years of age with acute coronary syndrome have 2x higher mortality compared with age-matched men.
- Trial name
- PRECADIW (NCT00544739)
- Where
- Poland
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Bullous Pemphigoid (BP), Cold Agglutinin Disease (CAD)
Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders
Prospective, double-blind, randomized, placebo-controlled First-In-Human study with four sub-parts: Part A, a single ascending dose study (SAD) in normal human volunteers (NHVs), Part B, a multiple ascending dose study (MAD) in…
- Conditions
- Bullous Pemphigoid (BP), Cold Agglutinin Disease (CAD), Warm Autoimmune Hemolytic Anemia (WAIHA), End-stage Renal Disease (ESRD)
- Trial name
- BIVV009-01 (NCT02502903)
- Testing
- BIV009
- Where
- Austria
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Bioverativ, a Sanofi company
Cancer Survivor, Diabetes Mellitus
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant
This pilot clinical trial studies computed tomography (CT) scans and biomarker analysis in diagnosing coronary artery disease (CAD) in patients who have undergone a stem cell transplant but have no symptoms of CAD.
- Conditions
- Cancer Survivor, Diabetes Mellitus, Hypertension
- Trial name
- NCT02077218
- Testing
- computed tomography, cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Coronary Artery Disease, Electrophysiology
Database Registry of the Intermountain Heart Collaborative Study
The purpose of the registry is to collect and analyze clinical and laboratory data and tissue samples from patients who are diagnosed with any type of heart disease and to collect the same information and samples from healthy…
- Conditions
- Coronary Artery Disease, Electrophysiology, Cardiovascular Disease
- Trial name
- NCT00406185
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Prosthesis (Internal) Complications
Comparison of Prosthetic Complications and Framework Misfit Among Different Cobalt-Chromium Framework Fabrication Techniques
This randomized clinical study aimed to compare prosthetic complications and framework misfit associated with three different fabrication techniques of cobalt-chromium frameworks-conventional casting, CAD/CAM milling, and…
- Trial name
- NCT07489027
- Testing
- Implant supported prosthesis
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Mansoura University