Clinical trials: CAD
Diabetes Mellitus, Hypertension
An International Prospective, Observational, Multi-centre Study on the Duration of Pre-operative Liquid Fasting
The investigators will be performing an international prospective, observational, multi-centre, cross-sectional study to determine the actual duration of preoperative liquid fasting time in European patients.
- Conditions
- Diabetes Mellitus, Hypertension, Ischaemic Heart Disease, Comorbidities and Coexisting Conditions
- Trial name
- THIRST (NCT06527703)
- Testing
- no intervention
- Where
- Malta
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Coronary Artery Disease
2D and Tissue Doppler Imaging Echocardiography Analysis of Left Ventricular Regional Wall Motion and Prognosis
Development of myocardial ischemia, and/or myocarditis would induce different changes in myocardial contraction behavior pattern,which maybe very subtle, and may not be detected by the 2D and m-mode echocardiography examinations.
- Trial name
- TDI (NCT01092429)
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cancer, Coronary Artery Disease
Calibration of MR and PET-MR Imaging Protocols at RIC
This is a protocol to facilitate on-site calibration of the technical aspects of the Siemens Biograph mMR (molecular MR) Positron Emission Tomography-Magnetic Resonance (PET-MR) scanner and the 3T Siemens Vida MR scanner at the…
- Trial name
- NCT02249520
- Testing
- PET-MR imaging on Biograph mMR scanner, MR-only imaging on Biograph mMR scanner, MR imaging on the Siemens Vida 3T MR scanner
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Coronary Microvascular Dysfunction, Ischaemia With Non Obstructed Coronary Arteries
Mechanisms Behind Microvascular Dysfunction in INOCA
The purpose of the study is to identify the causes of chest pain in patients experiencing chest pain with no signs of narrowing in the coronary arteries of the heart.
- Trial name
- ExINOCA-P1 (NCT06529861)
- Testing
- [15O]H2O-PET Imaging
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Coronary Artery Disease
A Phase I Study to Evaluate BFPET as a Potential Myocardial Perfusion Imaging(MPI) Agent for PET
Safety and dosimetry of BFPET™ will be evaluated in healthy volunteers and Coronary Artery Disease (CAD) patients , male or female and of age ranging between 20-80 years old.
- Trial name
- NCT00733460
- Testing
- BFPET
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fluoropharma, Inc.
Coronary Artery Disease
Myocardial Perfusion Imaging Galmydar Rest/Stress
A single center, phase 0/1 clinical imaging study designed to assess the role of [68Ga]Galmydar PET/CT imaging in human subjects.
- Trial name
- NCT05625490
- Testing
- Ga-68 Galmydar, 13N-ammonia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy, Hypercholesterolemia
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular disease (CVD).
- Conditions
- Healthy, Hypercholesterolemia, Hypertension, Overweight
- Trial name
- NCT06675994
- Testing
- PCSK9 Antibody, PCSK9 Enzyme
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Diabetes Mellitus, Type 2, Coronary Artery Disease
Optimizing Audit and Feedback for Primary Care
There remains a large gap between ideal and actual care provided to patients with chronic diseases. Performance feedback reports are often used as a foundation for quality improvement interventions.
- Trial name
- NCT00996645
- Testing
- Worksheet to facilitate goal-setting and action plans
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Inlays
This Trial Will Evaluate the Clinical Performance of Onlay Restorations Fabricated Using Rubber Dam Scanning Techniques.
The purpose of this study will be to evaluate the clinical performance of CAD-CAM onlay restorations fabricated using rubber dam scanning techniques up to 12 months and laboratory investigation of their marginal fit.
- Trial name
- NCT05978440
- Testing
- onlay preparation
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Frail Elderly, Coronary Artery Disease
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature.
- Trial name
- FRAGILE (NCT02338947)
- Testing
- Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
- Where
- 7 sites in United States, Brazil
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Middle Ear Disease
Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts
Prospectively analyze the use of 3D subtraction CAD/CAM in the operating room environment. Study participants, requiring middle ear surgery and ossicular reconstruction, will be implanted with one of two middle ear implants.
- Trial name
- NCT03297736
- Testing
- 3D CAD/CAM autograft prosthesis, Control device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nitinetics LLC
Coronary Disease
Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients
The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.
- Trial name
- NCT03899389
- Testing
- plasma samples collection
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Cardiovascular Diseases, Coronary Heart Disease
Umbrella Review and Updated Systematic Review and Meta-analysis of Pulses/Legumes and Incident Cardiometabolic Diseases
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding dietary pulses.
- Conditions
- Cardiovascular Diseases, Coronary Heart Disease, Stroke, Diabetes Mellitus, Type 2
- Trial name
- NCT03555734
- Testing
- Dietary pulses or legumes
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Coronary Artery Disease
Influence of Coffee on the Health and on the Heart of Normal, Diabetics e Coronary Artery Disease Patients
Coffee is a worldwide drink, been part of any culture. There are some concerns about effects of coffee on the health. Recently, epidemiological studies have shown benefits of coffee drinking to diabetics and also to prevent…
- Trial name
- Coffee&Heart (NCT01003392)
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Coronary Artery Disease
Clinical Values of Dose Reduction Techniques in Computed Tomography (CT) Coronary Artery Imaging With 64-row Multi-Slice Helical CT
To evaluate the clinical values of using dose reduction techniques in 64-row multi-slice CT coronary artery imaging.
- Trial name
- NCT01060657
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- General Hospital of Chinese Armed Police Forces
Periodontal Disease, Gingival Disease
Evaluation of Gingival Health Parameters in Hybrid CAD / CAM Crowns Produced After Different Retraction Processes
Clinically, the gingival retraction dentistry itself has found wide uses. It has achieved the use of subgingival and gingival crowns in fixed prostheses, cervical abrasion in restorative dentistry, management of root caries and…
- Trial name
- NCT03816930
- Testing
- mechanical cord usage
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Colorectal Cancer
A Multi Center Study Comparing the Efficacy of CAD EYE and the Standard of Care (White Light )
This study is to assess the sensitivity and added benefits of CADEYE compared to standard care (white-light) in detecting colon polyps in patients undergoing colonoscopy.
- Trial name
- NCT05523271
- Testing
- CAD EYE (Computer Aided Diagnosis ----?
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Edentulous Jaw, Dental Prosthesis, Implant-Supported
Accuracy of Standard and Geometric Pattern-Assisted Digital Scanning for Full-Arch Implant Prosthesis Frameworks
This clinical trial aims to compare three different impression techniques used to fabricate full-arch implant-supported dental prostheses.
- Conditions
- Edentulous Jaw, Dental Prosthesis, Implant-Supported, Prosthodontics, Dental Implantation, Endosseous
- Trial name
- GPA Scan (NCT07065487)
- Testing
- Intraoral Scanner - Standard Protocol, Intraoral Scanner with Geometric Reference Pattern, Conventional Splinted Impression Technique
- Where
- Egypt
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Mirna ashraf anis heneen