Clinical trials: CAD
Coronary Heart Disease Risk
GENErating Behavior Change, An Integrative Health Coaching and Genetic Risk Testing Pilot
The purpose of this 4 group (2x2) pilot randomized controlled trial is to test the feasibility and logistics of incorporating genetic risk information (9p21)into standard Coronary Heart Disease (CHD) risk counseling or health…
- Trial name
- NCT01766271
- Testing
- Health Coaching, 9p21, Standard Risk Assessment
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Coronary Artery Disease, Drug Eluting Stent
CREATE Trial, Prospective, Observational Study
Observation of the safety and effectiveness of Cre8 stent, Cre8 evo stent in patients with ischemic heart disease with long coronary lesions
- Trial name
- NCT05658250
- Testing
- CRE8 polymer-free Amphilimus-eluting stent, Cre8 evo stent
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Coronary Artery Disease
Tryton Post Approval Study (PAS) for the Tryton Side Branch Stent
TRYTON Post Approval Study (PAS) of the Tryton Side Branch Stent
- Trial name
- PAS (NCT03318796)
- Testing
- Coronary Artery Stenting
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Tryton Medical, Inc.
Lupus Erythematosus, Systemic
Analyzing the Association of Gene Variants With Increased Risk of Coronary Heart Disease in Women With Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects younger premenopausal women. The risk of coronary heat disease (CHD) in women with SLE is up to 50 times higher than in the general…
- Trial name
- NCT00563082
- Volunteers
- 1,254 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cardiovascular Diseases, Heart Diseases
The Jackson Heart Study of Cardiovascular Disease Among African Americans
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- JHS (NCT00005485)
- Where
- United States
- Volunteers
- 5,306 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hot Weather; Adverse Effect, Healthy
Characterization of Myocardial Blood Flow During Heat Exposure
The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.
- Conditions
- Hot Weather; Adverse Effect, Healthy, Coronary Artery Disease, Aging
- Trial name
- PET-Heat (NCT04549974)
- Testing
- Heat exposure
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Skeletal Abnormalities
Condylar Segment Repositioning Using CAD/CAM Generated Wafer After BSSO in Skeletal Mandibular Deformity
Maintaining the condylar position after bilateral sagittal split ramus osteotomy (BSSO) is one of the most important aspects in terms of condylar function ,.An altered condylar position can cause internal derangement of the…
- Trial name
- NCT03983265
- Testing
- Bilateral Sagittal Split Osteotomy
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy, Hypercholesterolemia
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular disease (CVD).
- Conditions
- Healthy, Hypercholesterolemia, Hypertension, Overweight
- Trial name
- NCT06675994
- Testing
- PCSK9 Antibody, PCSK9 Enzyme
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Increased Right Ventricular Radiotracer Uptake
Stress Induced Right Ventricular Uptake on Lexiscan Stress MPI
The objectives of this study are to determine the: 1. Diagnostic value of stress induced RV changes on Lexiscan stress MPI as compared to Exercise stress MPI in predicting a significant CAD. 2.
- Trial name
- RVuptakeLexi (NCT01697995)
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Aiden Abidov
Coronary Arterial Disease (CAD)
Central vs Brachial BP, Exercise, and Coronary Artery Disease
High blood pressure (BP) is a major risk factor for coronary artery disease (CAD), with 30-70% of CAD patients having elevated BP.
- Trial name
- NCT06617117
- Testing
- High-intensity combined exercise, Moderate-intensity combined exercise
- Where
- Portugal
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Coronary Heart Disease
Global Vascular Effects of Intermittent Pneumatic Compression-Pilot Study
Intermittent pneumatic compression (IPC) of the lower extremities is a well-established technique for preventing deep vein thrombosis (DVT) and for treating venous stasis.
- Trial name
- NCT01064323
- Testing
- Intermittent pneumatic compression of the lower extremities
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Coronary Heart Disease
Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
This study is being done to compare the blood flow measurements obtained with the SPECT and PET imaging scans. Measurements such as myocardial blood flow (MBF) and myocardial flow reserve (MFR) are analyzed on PET scans.
- Trial name
- SPECTMBF (NCT02280941)
- Testing
- single photon emission computed tomography
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Chronic Stable Coronary Artery Disease
Syndrome Differentiation in the Management of Chronic Stable Coronary Artery Disease (SCAD) to Improve Quality
1.1 To build a TCM diagnosis and treatment database for chronic stable CAD; 1.2 To summarize the pattern of TCM medicine used and the effect of the medication in chronic stable CAD.
- Trial name
- NCT03018769
- Testing
- Chinese Herb
- Where
- 32 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Periodontal Diseases
Influence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding Lectin
The premise of the relationship between the atherosclerotic process of coronary artery disease and periodontal disease is the immunoinflammatory process, which causes a significant increase in serum concentration of…
- Trial name
- NCT03753451
- Testing
- treatment of periodontal disease
- Where
- 2 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Microvascular Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
Heart failure with preserved ejection fraction (HFpEF) causes hospitalizations, premature mortality and high health care costs. This is also due to poor understanding of HFpEF pathogenesis and, thus, lack of specific therapies.
- Trial name
- MAPPED (NCT06316661)
- Testing
- stress perfusion cardiac magnetic resonance, cardiopulmonary exercise test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Procedural Anxiety, Coronary Artery Disease
Video-based Intervention to Reduce Anxiety in Patients Undergoing Elective PCI
This study aims to evaluate the effectiveness of a video-based educational intervention in reducing anxiety among hospitalised patients scheduled for elective percutaneous coronary intervention (PCI).
- Conditions
- Procedural Anxiety, Coronary Artery Disease, Percutaneous Coronary Intervention Patients
- Trial name
- NCT07485088
- Testing
- Video intervention
- Where
- Singapore
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Platelet Aggregation Inhibitors, Coronary Heart Disease
Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)
One of the most common ways for preventing coronary heart disease (CHD) is to take aspirin or clopidogrel. However, studies have shown that not all people respond to these medications.
- Trial name
- NCT00799396
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University