Clinical trials: CAD
Coronary Heart Disease, Type 2 Diabetes
Returning Genome and Metabolome Data to FinTerveys 2017 Participants: P5.fi FinTerveys Study
P5.fi study - P4 together with a fifth 'P' and '.fi' for population health Finally Implemented in Finland - studies the value of returning genetic and metabolomic risk information in two diseases (coronary heart disease and type…
- Conditions
- Coronary Heart Disease, Type 2 Diabetes, Deep Vein Thrombosis
- Trial name
- P5 (NCT03650127)
- Where
- Finland
- Volunteers
- 3,449 people, healthy volunteers welcome
- Sponsor
- Markus Perola
Spinal Anesthesia, Pregnancy
Ephedrine vs Phenylephrine - ECG Changes
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial ischaemia) many other…
- Trial name
- NCT01243970
- Testing
- Phenylephrine, Ephedrine
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Metabolic Syndrome, Coronary Heart Disease
Hämeenlinna Metabolic Syndrome Research Program: Surrogate Indicators for Atherosclerosis
Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS) surrogate indicators for atherosclerosis are studied in 120 men with…
- Trial name
- HMS-02 (NCT01119404)
- Where
- 4 sites in Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kanta-Häme Central Hospital
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.
Ischemic Heart Disease, Coronary Heart Disease
Metabolomics, Genomics and Nutrition for Cardiovascular Disease Precision Medicine
The objective of this project is to validate, through high-throughput advanced metabolomics techniques, the nutritional assessment tools to be used in the IMPaCT cohort.
- Trial name
- OMIC-CARD (NCT05706519)
- Where
- 6 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Coronary Artery Disease, Artificial Intelligence (AI)
Performance of an OCR-Prompt-LLM Integrated Workflow for Extracting Multi-dimensional Clinical Data in Ischemic Heart Disease
This research aims to evaluate a comprehensive AI-driven workflow for both clinical data extraction and diagnostic classification in coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Artificial Intelligence (AI), Data Collection
- Trial name
- OPAL-CAD (NCT07499830)
- Testing
- OCR-Prompt-LLM Information Extraction Workflow, Manual Clinical Data Review
- Where
- China
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Virtual Coronary Intervention and Non-invasive Fractional Flow Reserve (FFR)
The investigators examined the feasibility of treatment planning using virtual coronary revascularization and fractional flow reserve (FFR) CT before the invasive procedures.
- Trial name
- NCT01478100
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Coronary Angiography, Obesity
Optimizing Image Quality in Obese Patients Undergoing Coronary Computed Tomography (CT) Angiography
The purpose of this cardiovascular imaging research is to look at ways to improve the way we can look at the pictures of the heart.
- Conditions
- Coronary Angiography, Obesity, Coronary Disease
- Trial name
- BMI40 (NCT00468195)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Dental Restoration Failure
Clinical Performance of Two Different Resin-Matrix Ceramic Restorations
This study was designed to evaluate and compare the 2-year clinical performance of two different resin-matrix ceramic inlays
- Trial name
- NCT07265609
- Testing
- inlays
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Coronary Artery Disease, Healthy
Evaluation and Optimization of PB127 Myocardial Perfusion Echocardiography on Ultrasound Systems
The purpose of this clinical trial is to evaluate various commercially available ultrasound systems and to identify imaging parameters to be used with these systems (along with the contrast agent PB127) as well as to further…
- Trial name
- NCT00487903
- Testing
- PB127 for Injectable Suspension
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Point Biomedical
Coronary Artery Disease (CAD)
A Study to Assess the Amount of Drug Levels in Blood and Safety of AZD5718 Formulations in Healthy Volunteers
The study is a randomized, single-dose, open-label, combined 2x2 dose and 3x3 dose crossover design in fixed sequence. In this study, the relative bioavailability of different formulations of AZD5718 will be assessed in healthy…
- Trial name
- NCT04210388
- Testing
- AZD5718 tablet, Formulation A, AZD5718 tablet, Formulation B, AZD5718 tablet, Formulation C
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Coronary Artery Disease
FFRangio Accuracy vs. Standard FFR
This is a prospective, observational, multi-center, single-arm, clinical trial designed to assess the efficacy of FFRangio in measuring FFR obtained from angiography compared to Invasive FFR for diagnosing hemodynamically…
- Trial name
- FAST-FFR (NCT03226262)
- Testing
- FFRangio
- Where
- 9 sites in United States, Belgium and 2 more
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- CathWorks Ltd.
Back Pain, Coronary Artery Disease
Detecting and Addressing Preclinical Disability
The Physical Functioning Inventory (PFI) is a standardized patient reported outcome measure that assesses preclinical disability.
- Conditions
- Back Pain, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease, Diabetes
- Trial name
- NCT01979081
- Testing
- Tailored advice from a physiotherapist and/or an occupational therapist through the myOSCAR patient portal
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- McMaster University
Coronary Artery Disease, Diabetes Mellitus
Exercise Testing to Screen for Unknown Coronary Artery Disease in Diabetic Patients: Does it Contribute to a Risk Reduction in Very High Risk Patients?
In the present study a cohort of diabetic patients without any symptoms and without known coronary artery disease (CAD) will be screened at the investigators' diabetes outpatients services.
- Trial name
- DADDY-D (NCT00547872)
- Testing
- exercise testing - coronary angiography - revascularization
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- TURRINI FABRIZIO
Diagnosis
Automation Bias in Physician-LLM Diagnostic Reasoning
This study aims to systematically measure the extent and patterns of automation bias among physicians when utilizing ChatGPT-4o in clinical decision-making.
- Trial name
- NCT06963957
- Testing
- ChatGPT-4o Recommendations with Hallucinations
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Atherosclerosis, Stroke
Evaluation of Vascular Structure in Elderly Using High-frequency Ultrasound and Construction of a Multimodal Risk Assessment System for Cardiovascular Diseases: a Multicenter Study
Coronary heart disease(CHD), stroke, and hypertension are major diseases that seriously affect human health.Pathologic changes in the arteries involved in the above diseases mainly occur in the intimal or medial layer of the…
- Conditions
- Atherosclerosis, Stroke, Coronary Disease
- Trial name
- NCT06221618
- Testing
- High-frequency carotid arteries ultrasound, CCTA, Cranial MRA
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Atherosclerosis, Cardiovascular Diseases
Atherosclerosis, Plaque and CVD in Communities
To identify new cellular, metabolic, and genomic correlates of atherosclerotic plaque and early pathologic changes in the vascular wall and determine their consequences for coronary heart disease and stroke.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Cerebrovascular Accident
- Trial name
- NCT00091754
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Heart Disease
Impact of Race/Ethnicity on Platelet Function
The effects of race/ethnicity on platelet function and response to antiplatelet agents will be assessed using healthy participants and coronary heart disease patients from at least 5 racial/ethnic groups.
- Trial name
- NCT01168622
- Where
- United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Breast Cancer Risk, Cardiovascular Disease Risk
The RISC Registry--Risk Informed Screening Registry
Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States. Six in ten adults have one chronic disease; 4 in 10 have two or more.
- Conditions
- Breast Cancer Risk, Cardiovascular Disease Risk, Cardiometabolic Risk, Diabetes
- Trial name
- RISC (NCT05848856)
- Testing
- Breast Cancer, Cardiometabolic, Cardiovascular Risk Screening and Follow up
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Precision Health Equity Initiative
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies