Clinical trials: CAD-CAM
Edentulism Complete, Edentulism
PRINTOW: Occlusal Wear of Denture Teeth in Digitally Fabricated Complete Dentures
This randomized controlled trial evaluates the occlusal wear of denture teeth fabricated using three digital workflows: 3D-printed denture teeth, CAD/CAM-milled double cross-linked denture teeth, and prefabricated denture teeth.
- Trial name
- Printow (NCT07585162)
- Testing
- CAD/CAM-Milled Denture Base with Milled Denture Teeth, CAD/CAM-Milled Denture Base with Prefabricated Denture Teeth, 3D-printed denture base and teeth
- Volunteers
- 45 people
- Sponsor
- Najla Chebib
Complete Denture
Patient Satisfaction & Retention of Milled, 3D Printed and Conventional Complete Dentures
The objective of this trial is to compare patient satisfaction and retention of complete denture manufactured by three different techniques: CAD/CAM milling, CAD/CAM 3D printing and conventional technique.
- Trial name
- NCT03281603
- Testing
- CAD/CAM complete denture
- Where
- 2 sites in Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Ridge Augmentation, Dental Implants, Alveolar Ridge Deficiency in the Anterior Esthetic Zone
A Randomized Controlled Trial Evaluating Dental Implant Placement in the Anterior Esthetic Zone Using Two Guided Bone Regeneration Techniques: Prefabricated CAD/CAM Zirconia Membrane vs. Contour Augmentation.
This clinical trial aims to compare two guided bone regeneration (GBR) techniques in patients with horizontal ridge deficiency in the anterior esthetic region.
- Trial name
- RCT (NCT06987149)
- Testing
- CAD/CAM Zirconia Membrane, Contour Augmentation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mohammed Mashhout Eisa Anas
Osseointegration Failure of Dental Implant
Immediate Loading and Fully Guided Surgery: Single Implants
To evaluate the overall treatment outcome of single implants installed with the assistance of fully guided-surgery, submitted to immediate loading with restorations fabricated with the help of intraoral scanning, during a 1-year…
- Trial name
- NCT04061694
- Testing
- Immediate loading, fully guided surgery and 3D printed restoration, Immediate loading
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Folktandvården Skåne AB
Tooth Demineralization, Tooth Sensitivity
Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study
This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD/CAM indirect restorations (inlays, onlays, overlays) in molars affected by…
- Conditions
- Tooth Demineralization, Tooth Sensitivity, Enamel Mineralization Disorders, Tooth Sensitivity After Composite Restorations
- Trial name
- NCT07329244
- Testing
- Graphene-reinforced CAD/CAM polymer (G-CAM®)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universitat Internacional de Catalunya
Dental Esthetic, Dental Care for Children, Dental Crowns
Prefabricated CAD/CAM PEEK Crowns For Primary Molars Restoration
This Split-mouth randomized clinical trial aims to evaluate CAD/CAM prefabricated Polyether ether ketone crowns for primary molars restoration after pulpotomy compared to Stainless steel crowns Over follow-up periods of 3, 6, and…
- Trial name
- NCT07618871
- Testing
- Prefabricated CAD/CAM PEEK with 0.2 mm thickness, Prefabricated CAD/CAM PEEK with 0.4 mm thickness, CAD/CAM-fabricated PEEK Crowns
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Arab International University
Missing Teeth, Dentures
Comparison Between Conventional and CAD/CAM Complete Dentures Designed Based on Neutral Zone Concept
A within-subject cross-over study is done on eight completely edentulous patients to compare two different complete removable dentures.
- Trial name
- NCT05990088
- Testing
- Heat Cured Conventional Polymethylmethacrylate Complete Removable Dentures based on neutral zone concept, CAD/CAM Milled Methacrylate Complete Removable Dentures based on neutral zone concept.
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Tooth Loss
Ti-Mesh Frame Comparison for Alveolar Bone Augmentation
This research compares a chairside Titanium Mesh frame fabrication used during bone grafting procedures with the use of a computer-aided design/computer-assisted manufacture (CAD-CAM) Titanium Mesh frame.
- Trial name
- NCT06077513
- Testing
- CAD-CAM designed and preprinted Ti-Mesh frame, Conventional chairside fabrication of Ti-Mesh frame
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston University
CAD-CAM, Prospective Study
Clinical Evaluation of Additive and Subtractive Onlay Restorations
The goal of this clinical trial is to learn whether onlay restorations produced by additive manufacturing [three-dimensional (3D) printing] and subtractive manufacturing [Computer-Aided Design/Computer-Aided Manufacturing…
- Conditions
- CAD-CAM, Prospective Study, 3D Printing, Clinical Assessment
- Trial name
- CIP-ONLAY (NCT07195201)
- Testing
- 3D Printed Onlay Restoration, CAD/CAM Onlay Restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Ayse Tugba Erturk Avunduk
Evaluation of the Accuracy of Transferring the Virtual Planning to the Surgery
Accuracy of CAD/CAM Cutting Guides and Customized Titanium Plates for Virtual Planning Transfer in Bimaxillary Orthognathic Surgeries
In this research, we aim to use CAD/CAM surgical cutting guides for maxilla and mandible and customized titanium plates to guide all osteotomies and fixation of both arches.
- Trial name
- NCT04421144
- Testing
- orthognathic surgery
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vertical Ridge Deficiency, Horizontal Ridge Deficiency
Vertical and Horizontal Mandibular Ridge Augmentation Techniques
The purpose of this study is to compare alveolar ridge augmentation outcomes of two types of membranes for vertical and horizontal mandibular ridge augmentation: Customized CAD/CAM Titanium Mesh versus Reinforced Perforated PTFE…
- Trial name
- NCT06636084
- Testing
- Guided bone regeneration (GBR)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Alveolar Ridge Augmentation
Allograft Ridge Augmentation: 3D Analysis of CAD/CAM Custom Milled and Prefabricated Conventional Allogeneic Bone Blocks and Dental Implant Follow-up
To rehabilitate patients after the loss of their own teeth, dental implants are nowadays the therapy of choice if the indication is suitable.
- Trial name
- NCT06027710
- Testing
- Extensive alveolar ridge augmentation with allogeneic bone blocks; dental implant insertion in allogeneic bone graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Endocrown Restoration
Endocrown and 90° Shoulder Endocrown
Use chairside Computer-Aided Design \& Computer-Aided Manufacturing(CAD/CAM) system (computer aided design / manufacture), using glass ceramic zirconia enhanced lithium silicate glass ceramics (VITA, SUPRINITY, VS) material…
- Trial name
- NCT03398395
- Testing
- endocrown restoration, 90° shoulder endocrown restoration
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Partly Edentulous Maxilla
XiVE® CAD/CAM Bridges (Abutment-supported/ Implant-supported)
This study has been designed in order to collect data with regards to the peri-implant tissue outcome of abutment-supported restoration and direct implant-fixed restoration.
- Trial name
- XiCC (NCT01522365)
- Testing
- Abutment-supported XiVE CAD/CAM bridge, Implant-supported XiVE CAD/CAM bridge
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Dentsply Implants Manufacturing GmbH
Gross Material Loss in Endodontically Treated Upper and Lower Molars, No Systemic Infection
Clinical Performance of 3D-Printed vs. Milled Endocrowns
The goal of this clinical trial is to examine the durability of endocrowns, created using various materials and manufacturing techniques with a fully digital workflow, and their ability to maintain functionality and aesthetics in…
- Conditions
- Gross Material Loss in Endodontically Treated Upper and Lower Molars, No Systemic Infection, Gingival Steps Should be at Gum Level
- Trial name
- NCT06850649
- Testing
- endocrowns
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gulcan COSKUN AKAR
Endodontically Treated Teeth, Indirect Restoration
Clinical Performance of Printed Hybrid Resin in Indirect Restorations
This randomized clinical trial aims to evaluate the clinical performance of a 3D-printed hybrid resin (VarseoSmile TriniQ) used for indirect restorations in endodontically treated teeth, compared with a CAD/CAM composite block…
- Trial name
- NCT07465978
- Testing
- Indirect adhesive overlay restoration, Enamel Plus HRi, RelyX Universal
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universitat Internacional de Catalunya
Molar Incisor Hypomineralization
Computer-aided Design/Computer-aided Manufacturing for Mild to Moderate Molar Incisor Hypomineralization Treatment
Molar Incisor Hypomineralization (MIH) is a disease causing a structural defect in the enamel of permanent teeth. The treatment of these teeth consists of the removal of the affected part of the tooth and its reconstitution.
- Trial name
- MIhCFAO (NCT04922177)
- Testing
- Indirect ceramic restoration, Direct restoration
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Toulouse
Dentofacial Deformities
The Use of Bone-borne Guides in Orthognathic Surgery Cases
The present study was conducted to evaluate a new design of the intermediate stent that is used in orthognathic surgery cases requiring Le Fort I osteotomy.
- Trial name
- NCT04224805
- Testing
- Bone-borne CAD/CAM splint, 3D interocclusal conventional splint
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Dental Implant Failure, Dental Prosthesis Failure
DAMP1: The 1T1T Concept Versus Conventional Implant Loading Protocol
The One tooth - One time (1T1T) innovative approach is a straightforward and cost-effective protocol to replace a missing tooth in the posterior region (Lambert and Mainjot 2017) (see Appendix).
- Trial name
- NCT04045574
- Testing
- The 1T1T concept versus conventional implant loading protocol
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- University of Liege
Periodontal Diseases
Clinical and Radiographic Evaluation of The Effect of Acetal Resin Versus PEEK on Supporting Structure of Abutment Teeth
This study was conducted to evaluate and compare the effect of acetal resin versus Polyether ether ketone (PEEK) partial dentures on abutment teeth supporting structures in Kennedy class I mandibular partial denture cases.
- Trial name
- NCT06882161
- Testing
- Acetal resin
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University