Clinical trials: CD - Crohn's Disease
Crohn Disease
A Long Term Extension Trial of BI 655066/ABBV-066 (Risankizumab), in Patients With Moderately to Severely Active Crohn's Disease
The primary objective of the study was to investigate long-term safety of risankizumab (BI 655066/ABBV-066) in participants with moderately to severely active Crohn's disease who showed a clinical response or remission on…
- Trial name
- NCT02513459
- Testing
- Risankizumab 600 mg IV, Risankizumab 180 mg SC
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 65 people
- Sponsor
- AbbVie
Crohn's Disease
Early Immunosuppressants in Crohn's Disease
Pluricentric randomized study comparing two therapeutic strategies at beginning of Crohn's disease: early immunosuppressants (prescription within the six first months following diagnosis) vs.
- Trial name
- RAPID (NCT00546546)
- Testing
- early immunosuppressants (azathioprine, methotrexate)
- Where
- 26 sites in France
- Volunteers
- 120 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
CD
Changing the coUrse of cRohn's Disease With an Early Use of Adalimumab
This is a prospective, longitudinal, multicenter study conducted in a cohort of patients with early CD. This study will not change the patient/physician relationship.
- Trial name
- CURE (NCT03306446)
- Testing
- Start adalimumab in monotherapy
- Where
- 23 sites in Belgium, France
- Volunteers
- 203 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn's Disease (CD), Ulcerative Colitis (UC)
Virtual Group Therapy for IBD Patients With Anxiety and Depression
This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on symptoms of depression and anxiety.
- Conditions
- Crohn's Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD), Anxiety
- Trial name
- NCT07796568
- Testing
- Group Psychotherapy Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Chicago
Complex Perianal Fistula, Crohn Disease
Safety and Efficacy of Adipose-Derived Stem Cells to Treat Complex Perianal Fistulas Patients With Crohn's Disease
The purpose of this study is to determine safety and efficacy of eASCs (expanded adult stem cells) for treatment of complex perianal fistulas in patients with Crohn's disease.
- Trial name
- FATT (NCT01378390)
- Testing
- Expanded autologous adipose-derived adult stem cells (eASCs)
- Where
- 12 sites in Austria, Netherlands and 1 more
- Volunteers
- 56 people
- Sponsor
- Tigenix S.A.U.
Fibrostenotic Crohn's Disease
A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease
This is a Phase 1b, open-label, exploratory study designed to evaluate the pharmacodynamic effects of PALI-2108, a phosphodiesterase-4 (PDE4) inhibitor, in patients with fibrostenotic Crohn's disease (FSCD).
- Trial name
- NCT07428096
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Palisade Bio
Crohn's Disease
Adalimumab for the Induction and Maintenance of Clinical Remission in Subjects With Crohn's Disease
The purpose of this study is to test whether Adalimumab (at two different doses) can induce and maintain clinical remission in subjects with active Crohn's disease when compared to placebo (a substance containing no medication)
- Trial name
- CHARM (NCT00077779)
- Testing
- Adalimumab
- Where
- 43 sites in United States
- Volunteers
- 854 people
- Sponsor
- Abbott
Crohn Disease, Rectal Fistula
A Study of the Quality of Life in Adults With Crohn's Disease With Complex Perianal Fistulas
The main aim of the study is to assess the quality of life of people with Crohn's disease after treatment for complex perianal fistulas (CPF) in a standard clinic setting.
- Trial name
- CONFLICT (NCT04876690)
- Where
- 5 sites in Portugal
- Volunteers
- 15 people
- Sponsor
- Takeda
Crohn's Disease
Endoscopic Relapse Risks Evaluation After Ileocolic Resection for Crohn's Disease
Aim of the study: To evaluate risk factors of endoscopic relapse after ileocolic resection in a cohort of Crohn's disease patients treated with anti-TNF agents.
- Trial name
- RIC-1 (NCT06299631)
- Testing
- Ileocolic resection
- Where
- France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Montpellier
Crohn Disease
Standardized Microbiota Transplant Therapy in Crohn's Disease
Crohn's disease (CD) develops because of a disruption of homeostasis between the gut microbiota and the host immune system resulting in excessive inflammation in the intestinal tract.
- Trial name
- NCT06631586
- Testing
- MTP-101C, MTP-101S
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Inflammatory Bowel Disease, Crohn's Disease
Study of Participants With Crohn's Disease and Ulcerative Colitis in Eastern Europe, Middle East, and North Africa (P08166)
This study is being done to assess the clinical course and treatment options for Crohn's Disease (CD) and ulcerative colitis (UC) in the populations of Eastern Europe, Middle East, and North Africa.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01293656
- Testing
- No intervention.
- Sponsor
- Merck Sharp & Dohme LLC
Crohn Disease
Risankizumab in Children With Crohn's Disease (RisaKids)
The goal of this observational study is to to prospectively explore the real life short (12 weeks) and longer term (54 weeks) clinical, biochemical and endoscopic outcomes of risankizumab in pediatric CD.
- Trial name
- NCT06298188
- Testing
- Risankizumab
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Shaare Zedek Medical Center
Crohn Disease
Significance of Ficolin 2 in the Determination of Serological Activity in Chronic Inflammatory Bowel Disease
Background Determining disease activity in IBD is sometimes difficult and, to be accurate, requires endoscopy. The serum marker CRP has not proven sufficiently valuable as a marker for IBD specific inflammation.
- Trial name
- NCT01473927
- Testing
- Endoscopy
- Where
- 3 sites in Switzerland
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Bern
Inflammatory Bowel Disease (IBD), Crohn Disease
Evaluation of a Multimodal Day Hospital for the Overall Management of Patients With Chronic Inflammatory Bowel Diseases (IBD)
Inflammatory bowel diseases (IBD) are long-term conditions affecting more than 250,000 people in France. They typically begin in young adults and are characterized by flare-ups interspersed with periods of remission.
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn Disease, Ulcerative Colitis (Disorder)
- Trial name
- AMBUMIC (NCT07167186)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease, Crohn's Ileocolitis
PAtophysiological, Nodal-based Approach for Crohn's Disease Excision
Single centre prospective pilot study on surgery for Crohn's disease (CD). CD universally recurs after surgery and no technique so far has been proven to reduce recurrence.
- Trial name
- PANACEAPILOT (NCT04623476)
- Testing
- Pathophysiological Excision for Crohn's disease
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- University of Rome Tor Vergata
Crohn's Disease
Study Evaluating AZD7798 for Treatment in Crohn's Disease Patients With an Ileostomy
The purpose of this study is to evaluate safety, tolerability, and effect on mucosal repair of AZD7798 compared with placebo in participants with active ileal Crohn's disease and an ileostomy.
- Trial name
- CALLISTO (NCT06681324)
- Testing
- AZD7798
- Where
- 17 sites in Belgium, Italy and 5 more
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Crohn Disease, Prognostic Model
Study of Imaginomics Predicting Early Surgical Rates in Crohn's Disease
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic intestinal recurrent inflammatory disease involving the entire digestive tract.
- Conditions
- Crohn Disease, Prognostic Model, Radiomics
- Trial name
- NCT05174208
- Testing
- CTE examination
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease, Colitis
A Humanized Anti-Interferon-γ Monoclonal Antibody (HuZAF) for Moderate to Severe Crohn's Disease
The purpose of the HARMONY study is to assess the safety and efficacy of an investigational drug called HuZAF, in patients with moderate to severe Crohn's disease (CD).
- Conditions
- Crohn's Disease, Colitis, Intestinal Disease, Gastrointestinal Disease
- Trial name
- NCT00072943
- Testing
- anti-Interferon-gamma monoclonal antibody
- Where
- 19 sites in United States, Canada
- Volunteers
- 175 people
- Sponsor
- Facet Biotech
Inflammatory Bowel Diseases, Crohn's Disease
Efficacy and Safety Study of Tripterygium Glycoside in the Treatment of Crohn's Disease for Induction Remission
The purpose of this study is to assess the effect and safety of Tripterygium Glycosides in the treatment of Crohn's disease for induction remission and compare the therapeutic effect with patients who received mesalazine.
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Gastrointestinal Diseases, Digestive System Diseases
- Trial name
- NCT02044952
- Testing
- Mesalazine, Tripterygium glycosides
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhu Weiming
Crohn's Disease
Bioavailability of Vitamin D in Children and Adolescents With Crohn's Disease
The purpose of this study is to determine if high doses of vitamin D3 administered orally as adjunct therapy to children with Crohn's disease could improve the outcome of the disease.
- Trial name
- NCT01692808
- Testing
- Vitamin D3 3000 UI daily, Vitamin D3 4000 UI daily
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
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