Clinical trials: CERVICAL NEOPLASMS
Squamous Cell Carcinoma of Head and Neck
Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck
This study will test the ability of a personalized blood test to determine which head and neck cancer patients will have a recurrence after treatment.
- Trial name
- MRD-DUCHESS (NCT06744296)
- Testing
- Blood Draws and Tissue Sample(s)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Esophageal Cancer
Combination Chemotherapy in Treating Patients With Esophageal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00041262
- Testing
- cisplatin, epirubicin hydrochloride, fluorouracil
- Where
- United Kingdom
- Volunteers
- 1,300 people
- Sponsor
- Medical Research Council
Cancer, Head and Neck Cancer
Pilot Study of Management of Facial Paralysis in the Oncologic Patient: Nerve Transfer Techniques to Improve Facial Function and Quality of Life
The goal of this research study is to measure changes in patients' quality of life after surgeries that affect the facial nerve, including nerve transfer as treatment for facial paralysis.
- Trial name
- NCT06667427
- Testing
- Nerve transfer techniques
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
LOCALLY ADVANCED CERVICAL CANCERS
Outcomes of Image-guided High-dose-rate Uterovaginal Brachytherapy With Single Implantation
Background and Rationale: Locally advanced cervical cancer remains a major public health concern worldwide and in France. Standard-of-care management involves concurrent chemoradiotherapy followed by brachytherapy, which is…
- Trial name
- UNICURE-HD (NCT07213427)
- Testing
- data collection
- Volunteers
- 363 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Neoplasms
ROCOCO - Adaptive IMRT Versus IMPT in Head and Neck Cancer
Given the lack of evidence for the benefit of particle therapy in relevant cases, he investigators proposed an in silico trial to investigate the dosimetric effect of contour changes for OAR as well as tumor during chemoradiation…
- Trial name
- ROCOCO (NCT02908386)
- Where
- United States
- Sponsor
- Maastricht Radiation Oncology
Head and Neck Neoplasms
Effects of Nutritional Counseling on Nutritional Status and Quality of Life of Head and Neck Cancer Patients
This study investigates the effects of nutritional counseling versus standard nutritional care on nutritional status and quality of life in patients with head and neck cancer submitted to radiotherapy.Half participants will…
- Trial name
- NCT03114202
- Testing
- intensive nutritional counseling, Standard care
- Where
- 2 sites in Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Thyroid Cancer
The Value of 68Ga-FAPI PET/CT in Preoperative Evaluation of Thyroid Cancer with Lymph Node Metastases
This study aims to investigate the value of 68Ga-FAPI in the preoperative evaluation of thyroid cancer of different pathologic types.
- Trial name
- NCT06730529
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Esophageal Cancer
Two-field Versus Three-field Lymphadenectomy in Thoracic Esophageal Carcinoma Without Cervical Lymph Node Involvement
The purpose of this study is to compare the lymph node dissection results and prognosis in thoracic esophageal carcinoma patients without cervical lymph node involvement by preoperative CT and/or ultrasound treated by two-field…
- Trial name
- NCT02448953
- Testing
- Two-field lymphadenectomy, Three-field lymphadenectomy
- Where
- China
- Volunteers
- 786 people
- Sponsor
- Chinese Academy of Medical Sciences
Uterine Cervical Neoplasms, Cervical Cancer
The Kilimanjaro Cervical Screening Project
Although highly curable, cervical cancer kills thousands of women in developing countries annually. The investigators will pilot a project to improve detection of cervical cancer in Kilimanjaro, Tanzania through a program that…
- Trial name
- KCCP (NCT01968837)
- Testing
- Cervical cancer screening
- Where
- Tanzania
- Volunteers
- 1,072 people, healthy volunteers welcome
- Sponsor
- Queen's University
Infections, Papillomavirus
Efficacy Study of HPV-16/18 Vaccine (GSK 580299) to Prevent HPV-16 and/or -18 Cervical Infection in Young Healthy Women
The purpose of this phase IIB MedImmune-sponsored study was to evaluate the efficacy of the HPV-16/18 VLP vaccine in the prevention of infection with HPV-16 and/or HPV-18 in adolescent and young adult women.
- Trial name
- NCT00689741
- Testing
- Cervarix
- Volunteers
- 1,113 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Head & Neck Squamous Cell Carcinoma
Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.
This multicenter prospective observational study will evaluate the value of dynamic FDG-PET LAFOV imaging during the initial therapeutic assessment of a head and neck cancer 3 months after completion of curative radiotherapy.
- Trial name
- POLARIS (NCT07417605)
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Brest
Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial
- Trial name
- NCT05544929
- Testing
- KFA115, pembrolizumab
- Where
- 18 sites in United States, Canada and 10 more
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Cervical Carcinoma, Human Papillomavirus Infection
Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S02)
This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention.
- Trial name
- NCT06611553
- Testing
- Biospecimen Collection, Cervical Biopsy, Colposcopy
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Nodule, Thyroid Diseases
Effectiveness of Core-Needle US Guided Biopsy as Primary Tool For Diagnosis of Thyroid Nodules
The study aimed to determine the best intervention between Core biopsy and Fine needle aspiration in diagnosis of thyroid malignancy.
- Conditions
- Thyroid Nodule, Thyroid Diseases, Thyroid Gland; Node
- Trial name
- NCT04759053
- Testing
- FNB, Core biopsy
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Nasopharyngeal Carcinoma, Induction Chemotherapy
Reducing Target Volumes in NPC Treated With Induction Chemotherapy Followed by Concurrent Chemoradiotherapy
To evaluate the long-term locoregional control, survival rate, late toxicity and quality of life after reducing the target volume in patients with locoregionally advanced nasopharyngeal carcinoma patients treated with induction…
- Conditions
- Nasopharyngeal Carcinoma, Induction Chemotherapy, Radiotherapy
- Trial name
- NPC-GTV (NCT04384627)
- Testing
- Delineating the GTV according to the pretreatment or post-IC tumor extension
- Where
- 2 sites in China
- Volunteers
- 445 people
- Sponsor
- Sun Yat-sen University
Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer
A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation
This is a phase II, single center, open label, multi-cohort platform study to identify a signature in tumor tissues, blood or stool that might help identify participants who are more likely to experience tumor shrinkage or side…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck
- Trial name
- DOME (NCT04262388)
- Testing
- Durvalumab, Oleclumab
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Uterine Cervical Neoplasms
Urinary and Vaginal HPV Testing in Cervical Cancer Screening
Cervical cancer, caused by high-risk human papillomavirus (HPV) infection, poses a problem worldwide as it is the fourth most common female cancer.
- Trial name
- NCT05065853
- Testing
- urine self-sampling group, clinician-collected cervical sample group
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Squamous Cell Carcinoma of the Head and Neck
Debio 1143-201 Dose-finding and Efficacy Phase I/II Trial
The use of multiple drugs in a single clinical trial or as a therapeutic strategy has become common, particularly in the treatment of cancer.
- Trial name
- NCT02022098
- Testing
- Cisplatin, Radiotherapy, Debio 1143
- Where
- 19 sites in France, Switzerland
- Volunteers
- 144 people
- Sponsor
- Debiopharm International SA
Cervical Cancer, HPV Cancers
Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies
Background: More than 30,000 cases of human papillomavirus (HPV) associated cancers occur annually in the United States. When these cancers spread, they do not respond well to standard treatments and are often incurable.
- Conditions
- Cervical Cancer, HPV Cancers, Anal Cancer, Oropharyngeal Cancer
- Trial name
- NCT04287868
- Testing
- PDS0101, M7824, NHS-IL12
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute (NCI)
PFS, OS
Neoadjuvant Chemotherapy + Surgery Versus Surgery in FIGO IB2 and IIA2 Cervical Cancer
To clarify the potential benefits of NACT before radical surgery(RS), we perform a phase III, randomised controlled trial to compare NACT plus RS with RS alone in patients with stages IB2 and IIA2 cervical cancer.
- Conditions
- PFS, OS, Quality of Life
- Trial name
- SYSGO-003 (NCT02629718)
- Testing
- NACT (Paclitaxel + Cisplatin or carboplatin), radical surgery
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Sun Yat-sen University
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