Clinical trials: CLBP - Chronic Low Back Pain
Nociceptive Pain, Axial Back Pain
Ultra Low Frequency Neuromodulation for Nociceptive Chronic Low Back Pain
The goal of this clinical trial is to learn if Ultra Low Frequency (ULF) neuromodulation works to treat nociceptive chronic low back pain in adults. It will also evaluate the safety of ULF therapy.
- Trial name
- NCT06763653
- Testing
- ULF therapy, CMM
- Where
- 3 sites in Australia
- Volunteers
- 303 people
- Sponsor
- Presidio Medical, Inc
Degenerative Disc Disease, Chronic Low-back Pain
Post Market Observational Trial for the PerQdisc Nucleus Replacement Device
PerQdisc PMCF1 is a post-market clinical follow-up observational trial to follow subjects receiving a PerQdisc spinal implant for a duration of 5 years.
- Trial name
- PMCF1 (NCT05105490)
- Testing
- PerQdisc
- Where
- Germany
- Sponsor
- Spinal Stabilization Technologies
Low Back Pain, Mechanical
Effectiveness of Tricortin 1000 in Patients Affected by Chronic Low Back Pain
PAES, double blind, double dummy, multicenter, randomized, controlled clinical study to demonstrate superiority of Tricortin 1000 over placebo in improvement in pain relief as change from baseline to 15 days in patients with…
- Trial name
- NCT04585334
- Testing
- Tricortin 1000, Itami
- Where
- 13 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Low Back Pain
A Study of Tanezumab in Adults With Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of multiple doses of tanezumab administered every 8 weeks in treating chronic low back pain.
- Trial name
- NCT00876187
- Testing
- Tanezumab 20 mg IV, Tanezumab 10 mg IV, Tanezumab 5 mg IV
- Where
- 135 sites in United States
- Volunteers
- 1,359 people
- Sponsor
- Pfizer
Chronic Pain
Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain
The purpose of this prospective post market observational pilot study is to evaluate the effect of DRG stimulation in the management of chronic discogenic pain in subjects who are refractory to other available treatments.
- Trial name
- NCT02587637
- Testing
- Dorsal root ganglion (DRG) stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Chronic Low-back Pain
ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation
This study is a prospective, randomized study comparing ReActiv8 Therapy to Optimal Medical Management (OMM).
- Trial name
- RESTORE (NCT04803214)
- Testing
- ReActiv8
- Where
- 28 sites in United States
- Volunteers
- 203 people
- Sponsor
- Mainstay Medical
Low Back Pain
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects
The purpose of the study is to determine if buprenorphine hydrochloride (HCl) buccal film is effective in treating opioid-experienced subjects, with moderate to severe chronic low back pain (CLBP), who require continuous…
- Trial name
- NCT01675167
- Testing
- Buprenorphine
- Where
- 66 sites in United States
- Volunteers
- 815 people
- Sponsor
- BioDelivery Sciences International
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Low Back Pain
Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets
This is a 6-month, nonrandomized, open-label extension study to assess the long-term safety of hydrocodone bitartrate extended-release (ER) tablets in patients with moderate to severe chronic low back pain who require continuous…
- Trial name
- NCT01922739
- Testing
- Hydrocodone ER
- Where
- 61 sites in United States
- Volunteers
- 182 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Low Back Pain, Leg Pain
MIS MiLIF Versus Open
This study is being undertaken to compare the clinical outcomes of patients that have unilateral posterolateral lumbar interbody fusion using a traditional open approach versus the MiLIF procedure based on the MiCOR Precision…
- Trial name
- NCT00792129
- Testing
- The Atavi System
- Where
- 9 sites in United States
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Chronic Low-back Pain
Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain
Phase III longitudinal, multicenter, randomized, double-blind clinical trial. The aim of this study is to evaluate the efficacy and security of the drug combination of Celecoxib / Pregabalin / Vitamin B versus Celecoxib + Vitamin…
- Trial name
- NCT06516094
- Testing
- Celecoxib+Pregabalin+Vitamin B fixed dose, Celecoxib + Vitamin B fixed dose, Pregabalin + Vitamin B fixed dose
- Where
- Mexico
- Volunteers
- 192 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Chronic Low Back Pain
A Study Comparing The Efficacy And Safety Of Lidocaine 5% Patch With Placebo In Patients With Chronic Axial Low Back Pain
Patients with Chronic Axial Low Back Pain participated in a Phase II clinical trial to assess the efficacy of lidocaine 5% patch compared with placebo.
- Trial name
- NCT00904111
- Testing
- Lidoderm®
- Where
- 18 sites in United States
- Volunteers
- 215 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Chronic Low Back Pain (CLBP)
SENECA - Smart Therapies for Chronic Pain
This will be a randomized controlled prospective pilot study: The feasibility and usability of VIVO 2nd GEN therapy + Standard-of-Care (SoC) vs. Standard-of-Care alone will be evaluated.
- Trial name
- SENECA (NCT07628179)
- Testing
- VIVO 2nd GEN, Standard-of-Care Multimodal Pain Therapy
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Aurimod GmbH
Low Back Pain
Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940
A Phase I, Multi-Centre, Randomised, Double-blind, Placebo-controlled Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940, Including an Interaction Study, After Administration of Oral Multiple Ascending…
- Trial name
- NCT00689780
- Testing
- AZD1940, Midazolam
- Where
- 3 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Chronic Lower Back Pain
Virtual Reality Trial Using EaseVRx For Chronic Low Back Pain
Randomized, 2-arm parallel group clinical trial evaluating the effectiveness of a self-administered Virtual Reality program for the treatment of chronic lower back pain compared to a placebo VR program.
- Trial name
- NCT04415177
- Testing
- EaseVRx headset with active intervention, EaseVRx headset without active intervention
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- AppliedVR Inc.
Back Pain, Low Back Pain
Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.
This was a clinical effectiveness trial designed to compare the effectiveness, safety, and tolerability of treatment with tapentadol prolonged release with that of oxycodone/naloxone prolonged release in non-opioid pre-treated…
- Conditions
- Back Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT01838616
- Testing
- Tapentadol Prolonged Release, Oxycodone/Naloxone Prolonged Release
- Where
- 50 sites in Austria, Germany and 2 more
- Volunteers
- 367 people
- Sponsor
- Grünenthal GmbH
Opioid Use, Low Back Pain
Impact of DuoTherm on Opioid Use and Low Back Pain
Evaluate the difference in opioid use, pain intensity and pain interference in patients with moderate to severe low back pain using DuoTherm multimodal harmonic mechanical stimulation (M-Stim) unit compared to Transcutaneous…
- Trial name
- NCT04491175
- Testing
- M-Stim, TENS
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- MMJ Labs LLC
Chronic Low Back Pain
Five-Plus Year Follow-Up of SMART Randomized Controlled Trial
The objective of this study is to evaluate long-term ongoing effectiveness of the Intracept Intraosseous Nerve Ablation System for the treatment of chronic low back pain.
- Trial name
- SMART (NCT03997825)
- Testing
- Basivertebral Nerve (BVN) Ablation
- Where
- 13 sites in United States
- Volunteers
- 117 people
- Sponsor
- Relievant Medsystems, Inc.
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended-release Tramadol Versus Placebo in the Treatment of Chronic Low Back Pain
The purpose of this study is to compare the analgesic efficacy of oral, once-daily tramadol ER 300 mg and 200 mg to placebo in patients with moderate to severe chronic low back pain requiring daily analgesic treatment.
- Trial name
- NCT00347724
- Testing
- Tramadol HCl ER
- Volunteers
- 600 people
- Sponsor
- Bausch Health Americas, Inc.