Clinical trials: CLBP - Chronic Low Back Pain
Chronic Low Back Pain
Placebo In Chronic Back Pain (Phase 2)
This study is designed to examine brain properties for placebo response in chronic back pain patients. The investigators have preliminary data indicating that, in blinded clinical trial studies with neutral instructions regarding…
- Trial name
- PICP2 (NCT02986334)
- Testing
- Naproxen, Omeprazole
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Apkar Apkarian
Chronic Low-back Pain
Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain
A Phase 1b study to investigate the efficacy of PP353 compared to placebo in the treatment of chronic low back pain associated with bone oedema.
- Trial name
- NCT04238676
- Testing
- PP353
- Where
- 10 sites in Denmark, New Zealand and 2 more
- Volunteers
- 43 people
- Sponsor
- Persica Pharmaceuticals Ltd
Non-specific Chronic Low Back Pain
An Interactive Gaming-based Intervention for Back Pain
This study aims to compare the outcomes of a traditional, exercise-based rehabilitation intervention for chronic low back pain with the outcomes achieved by combining a traditional intervention with adjunct therapy delivered…
- Trial name
- NCT02503410
- Testing
- Usual care, Interactive gaming
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Spaulding Rehabilitation Hospital
Chronic Low-back Pain
A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Chronic Low Back Pain
The main purpose of this study is to assess whether LY3857210 is safe and efficacious in relieving chronic low back pain (CLBP).
- Trial name
- NCT05630196
- Testing
- LY3857210
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 138 people
- Sponsor
- Eli Lilly and Company
Chronic Low Back Pain
Five-Plus Year Follow-Up of SMART Randomized Controlled Trial
The objective of this study is to evaluate long-term ongoing effectiveness of the Intracept Intraosseous Nerve Ablation System for the treatment of chronic low back pain.
- Trial name
- SMART (NCT03997825)
- Testing
- Basivertebral Nerve (BVN) Ablation
- Where
- 13 sites in United States
- Volunteers
- 117 people
- Sponsor
- Relievant Medsystems, Inc.
Chronic Low Back Pain
Placebo In Chronic Back Pain - Double-Blind Randomized Control Trial
This study is designed to examine brain properties for placebo response in chronic back pain patients. The investigators have preliminary data indicating that, in blinded clinical trial studies with neutral instructions regarding…
- Trial name
- NCT02013427
- Testing
- Naproxen, Omeprazole
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Northwestern University
Low Back Pain
Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets
This is a 6-month, nonrandomized, open-label extension study to assess the long-term safety of hydrocodone bitartrate extended-release (ER) tablets in patients with moderate to severe chronic low back pain who require continuous…
- Trial name
- NCT01922739
- Testing
- Hydrocodone ER
- Where
- 61 sites in United States
- Volunteers
- 182 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Pain
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain (CP) management has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (via greater exposure in vulnerable individuals), non-pain health consequences (hormone…
- Trial name
- NCT02469077
- Testing
- 6 week aerobic exercise intervention, Morphine, naloxone
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- Vanderbilt University Medical Center
Low Back Pain
The Efficacy of the Kyrobak for Chronic Low Back Pain (LBP-2)
The purpose of this study is to evaluate the efficacy of the Kyrobak continuous passive motion home-use device in relieving low back pain, improving proprioception (balance and fall prevention) and improving the symmetry of…
- Trial name
- LBP-2 (NCT02155283)
- Testing
- Continuous Passive Motion
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Radiancy
Chronic Low Back Pain
ReActiv8 Post Market Surveillance Registry
To gather data on the long-term safety of ReActiv8 and identify any residual risks by reporting all Serious Adverse Device Effects as well as performance and health care utilization through two years post-implant.
- Trial name
- ReActiv8-C (NCT03255200)
- Testing
- ReActiv8 Implantable Stimulation System
- Where
- 5 sites in Germany
- Volunteers
- 87 people
- Sponsor
- Mainstay Medical
Low Back Pain
Selecting Effective Combinations of Treatment for Low Back Pain
Back pain is the #1 contributor to disability in the United States (US), and second only to hearing problems as a reason for new Veteran disability compensation.
- Trial name
- SELECT LBP (NCT03520387)
- Testing
- Lumbar medial branch nerve radiofrequency ablation (LRFA), Simulated LRFA with targeted steroid injections, AcTIVE-CBT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Effectiveness of Thoracic Facet Joint Nerve Blocks
1. To demonstrate whether: i. Facet joint nerve blocks have therapeutic value beyond the duration of local anesthetic effect. ii.
- Trial name
- NCT00355706
- Testing
- Thoracic facet joint nerve blocks
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pain Management Center of Paducah
Chronic Pain, Fibromyalgia
Developing an Activity Pacing Framework: Feasibility and Acceptability
This study explores whether it is feasible to use a newly developed activity pacing framework to standardise how activity pacing is instructed by healthcare professionals in rehabilitation programmes for patients with chronic…
- Conditions
- Chronic Pain, Fibromyalgia, Chronic Fatigue Syndrome, Chronic Low Back Pain
- Trial name
- NCT03497585
- Testing
- Activity pacing framework
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- Pennine Acute Hospitals NHS Trust
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Back Pain Lower Back Chronic
Phase 3 Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Low Back Pain
The purpose of the study is to evaluate the safety and efficacy of Hydrocodone Bitartrate controlled-release capsules in subjects with chronic low back pain.
- Trial name
- NCT01081912
- Testing
- Hydrocodone bitartrate
- Where
- 51 sites in United States
- Volunteers
- 510 people
- Sponsor
- Zogenix, Inc.
Low Back Pain, Chronic Pain
Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain
The purpose of this 52-week open label study is to determine the long-term safety of a new opioid molecule, NKTR-181, in patients with moderate to severe chronic low back pain or chronic non-cancer pain.
- Trial name
- SUMMIT-LTS (NCT02367820)
- Testing
- NKTR-181 BID tablets
- Where
- 56 sites in United States
- Volunteers
- 638 people
- Sponsor
- Nektar Therapeutics
Low Back Pain
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Severe Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl patch (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01774903
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 45 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Low Back Pain
Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain
The primary objective of this study is to evaluate the efficacy of hydrocodone bitartrate extended-release tablets at doses of 30 to 90 mg every 12 hours compared with placebo in alleviating moderate to severe pain in patients…
- Trial name
- NCT01789970
- Testing
- Hydrocodone ER
- Where
- 87 sites in United States
- Volunteers
- 625 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Pain, Low Back Pain
Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain
The purpose of this study is to determine whether buprenorphine hydrochloride (HCl) buccal film is effective and safe in the treatment of chronic low back pain (CLBP).
- Trial name
- NCT01256450
- Testing
- Buprenorphine
- Where
- 24 sites in United States
- Volunteers
- 334 people
- Sponsor
- BioDelivery Sciences International
Pain, Chronic Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking WHO Step III…
- Conditions
- Pain, Chronic Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT00986258
- Testing
- Tapentadol Prolonged Release
- Where
- 27 sites in Belgium, Czechia and 6 more
- Volunteers
- 136 people
- Sponsor
- Grünenthal GmbH