Clinical trials: CLE
Cutaneous Lupus Erythematosus(CLE)
A Study on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of SHR-7012 in Healthy Adults
A Study on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of SHR-7012 in Healthy Adults
- Trial name
- NCT07749651
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Eosinophilic Esophagitis
Confocal Laser Endomicroscopy in Patients With Eosinophilic Esophagitis
Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution.
- Trial name
- NCT01234376
- Testing
- Confocal laser endomicroscopy
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Systemic Lupus Erythematosus (SLE) or Cutaneous Lupus Erythematosus
A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE/CLE Participants
A Phase 1/2a Study of DB-2304 in Healthy Participants and Participants with Systemic Lupus Erythematosus or Cutaneous Lupus Erythematosus
- Trial name
- NCT06625671
- Testing
- DB-2304, Prednisone
- Where
- 7 sites in United States, Australia
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- DualityBio Inc.
Cutaneous Lupus Erythematosus
Deep Phenotyping of Cutaneous Lupus Erythematosus
Cutaneous lupus erythematosus (CLE) is an autoimmune disease of which the pathogenesis and pathophysiology are not fully understood.
- Trial name
- NCT06411106
- Testing
- IMIQUIMOD cream 50mg/g
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Pancreatic Neoplasms, CHRONIC PANCREATITIS
Needle-based Confocal Endomicroscopy Examination of Pancreatic Masse
Introduction: Pancreatic cancer is one of the most aggressive malignancies with only 5% of patients being alive at five years. EUS (endoscopic ultra sound) is an established, sensitive diagnostic tool in pancreatic cancer and for…
- Trial name
- NCT01734967
- Testing
- needle based CLE, EUS-FNA
- Where
- 2 sites in Denmark, Romania
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Chronic Lateral Epicondylosis
PEAK Platelet Rich Plasma Injection Treatment for Chronic Lateral Epicondylosis
The proposed project will be the first to assess pain- and function-dependent, elbow-specific quality of life and in-vivo mechanical properties of common extensor tendons post-treatment with PRP in a Level 1, RCT with subject and…
- Trial name
- NCT03072381
- Testing
- Platelet Rich Plasma - Group 1, Corticosteroid Control - Group 2
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Irritable Bowel Syndrome, Food Sensitivity
Confocal Laser Endomicroscopy to Determine Influence of Food Antigens on Mucosal Integrity
Irritable bowel syndrome (IBS) is mainly associated with food intolerance and presents a particular challenge in gastrointestinal practice.
- Conditions
- Irritable Bowel Syndrome, Food Sensitivity, Healthy Controls
- Trial name
- RDS_CLE (NCT05056610)
- Testing
- food antigens on duodenal mucosa
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory, Interstitial, Rare Lung Diseases
The Study Of Probe-Based Confocal Laser Endomicroscopy Of Distal Airways In Diagnostics Of Lung Diseases
The study is devoted to the comparative analysis of the data received in patients with lung pathology using new method of probe-based confocal laser endoscopy of distal airways and two reference methods: high resolution computed…
- Trial name
- pCLE (NCT02006940)
- Testing
- miniprobe Alveoflex
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
IBS, Food Intolerance
Confocal Laser Endomicroscopy in IBS Patients
This study will assess dynamic effects of two major antigens on the duodenal mucosa by confocal laser endomicroscopy (CLE). Patients will be blinded to the antigens used (wheat, yeast).
- Trial name
- NCT02313207
- Testing
- FODMAP
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Irritable Bowel Syndrome
ConfocAl endomicroSCopy bAsed Diet Trial in IBS
After a thorough baseline evaluation, IBS patients will be exposed to nutrients while undergoing confocal laser endomicroscopy (CLE).
- Trial name
- CASCADE (NCT05097872)
- Testing
- Diet
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Flow Determination
Real-time Observation of Microcirculatory Hemodynamics in Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The morphologic change of microvessels has the clinical value to distinguish cancerous from non-cancerous mucosa. The aim of this study was to observe gastric mucosa microcirculatory hemodynamic changes real-time using pCLE…
- Trial name
- NCT02595151
- Testing
- CLE
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shandong University
Healthy Volunteers, Systemic Lupus Erythematosus (SLE)
A Study of KK4277 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus
Part 1 : To evaluate the safety and tolerability of a single intravenous (IV) or subcutaneous (SC) dose of KK4277 in healthy Japanese or non-Asian adult males.
- Conditions
- Healthy Volunteers, Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE)
- Trial name
- NCT05411016
- Testing
- KK4277
- Where
- 23 sites in Japan, South Korea
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Non-celiac Gluten Sensitivity, Wheat Hypersensitivity
Wheat Bread Study: Comparison of the Tolerance of Different Wheat Breads
This study aims to assess the differences in tolerability of differently manufactured wheat breads in a target group of individuals with suspected wheat sensitivity.
- Trial name
- NCT06152445
- Testing
- Wheat bread
- Where
- 2 sites in Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Colorectal Neoplasia, Colorectal Inflammation
Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome
The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.
- Conditions
- Colorectal Neoplasia, Colorectal Inflammation, Hyperplasia, Mucosal Microbiome
- Trial name
- NCT02063919
- Testing
- the mucosal microbiome in the biopsy specimen was analysed
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shandong University
Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence
Automatic Classification of Colorectal Polyps Using Probe-based Endomicroscopy With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables real-time histological evaluation of gastrointestinal mucosa during ongoing endoscopy examination.
- Conditions
- Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence, Colorectal Polyps
- Trial name
- NCT03787784
- Testing
- AI presentation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Cutaneous Lupus Erythematosus
Sunscreens in Patients With Cutaneous Lupus Erythematosus(CLE)
Part I: to investigate the efficacy of different sunscreens in the prevention of skin lesions following standardized photoprovocation with Ultraviolet A/Ultraviolet B (UVA/UVB) light in patients with CLE.
- Trial name
- NCT01146444
- Testing
- UV A and B irradiation
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Spirig Pharma Ltd.
Gastroesophageal Reflux Disease
Detection of Minimal Change Esophagitis Using Confocal Laser Endomicroscopy
This is an observational, prospective and pilot study to determine through confocal endomicroscopy diagnostic microscopic features detectable at the gastroesophageal junction of patients with non-erosive gastroesophageal reflux…
- Trial name
- NCT00954070
- Testing
- Confocal endomicroscope (Pentax Model EC3870K)
- Where
- Singapore
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Inflammatory Bowel Disease, Ulcerative Colitis
Assessment of Colonic Permeability by Confocal Laser Endomicroscopy
The purpose of this study is to evaluate the efficacy of confocal laser endomicroscopy in assessment of colonic permeability against conventional sugar absorption test.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Irritable Bowel Syndrome
- Trial name
- NCT00883077
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Crohn Disease
Characterization of Crohn's Disease at Confocal Laser Endomicroscopy (CLE) and Related to Disease Activity
A blinded prospective observation and methodology study with Confocal Laser Endomicroscopy (CLE) together with standard white light colonoscopy including inter- and intra-observation of patients with Crohn's disease.
- Trial name
- NCT01738529
- Testing
- CLE ileocolonoscopy
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital