Clinical trials: CLE
Pancreatic Cysts
Confocal Endomicroscopy of Pancreatic InVivo
Confocal laser endomicroscopy (CLE) is a novel and highly promising imaging method for that allows in vivo imaging of the mucosal layer at resolution of approximately 1 micron.
- Trial name
- NCT01035008
- Testing
- Endoscopic Ultrasound (EUS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus
Study of M5049 in CLE and SLE Participants
This study is to evaluate the safety, tolerability and pharmacokinetics (PK) of orally administered M5049 in participants with systemic lupus erythematosus (SLE) or cutaneous lupus erythematosus (CLE).
- Trial name
- NCT04647708
- Testing
- M5049
- Where
- 12 sites in Bulgaria, Germany and 4 more
- Volunteers
- 25 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Breast Cancer Invasive, Breast Cancer Surgery
Confocal Histolog Scanner in Routine Breast-Conserving Surgery (CHiB)
The clinical performance study is collecting data from the use of a CE mark product used within the scope of its intended purpose to intraoperatively visualize tissue specimen.
- Conditions
- Breast Cancer Invasive, Breast Cancer Surgery, Lumpectomy, Confocal Laser Endomicroscopy
- Trial name
- CHiB (NCT06958991)
- Testing
- Histolog Scanner
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Fribourg
Lupus Erythematosus, Systemic
A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with systemic lupus erythematosus (SLE).
- Trial name
- TOPAZ-1 (NCT04895241)
- Testing
- Litifilimab
- Where
- 164 sites in United States, Australia and 13 more
- Volunteers
- 548 people
- Sponsor
- Biogen
Cutaneous Lupus Erythematosus
A Multiple Dose Study Of PD-0360324 In Patients With Active Cutaneous Lupus Erythematosus
This study is designed to evaluate the safety and tolerability of multiple intravenously administered doses of PD-0360324 in patients with cutaneous lupus erythematosus. Changes in disease activity will also be evaluated.
- Trial name
- NCT01470313
- Testing
- PD-0360324
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 28 people
- Sponsor
- Pfizer
Mucosal Microbiome, H.Pylori
Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome
There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.
- Conditions
- Mucosal Microbiome, H.Pylori, Intestinal Metaplasia, Gastric Neoplasia
- Trial name
- NCT02063932
- Testing
- endomicroscopy, targeted biopsy and 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Frozen Sections, Indocyanine Green
Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.
The primary objective of this study is to demonstrate the non-inferiority of cCeLL compared to frozen section analysis. The investigational device is intended for use with indocyanine green (ICG) for fluorescence imaging as an…
- Conditions
- Frozen Sections, Indocyanine Green, Brain Tumor
- Trial name
- PRECISION (NCT06867978)
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 100 people
- Sponsor
- VPIX Medical
Pancreatic Cysts
Diagnosis of Pancreatic Cysts: Endoscopic Ultrasound With Fine Needle Aspiration (EUS/FNA), Direct Visualization, and Confocal Laser-induced Endomicroscopy-A Pilot Study
The purpose of this study is to assess the yield of combination modalities in the diagnosis of pancreatic cysts using EUS/FNA, Fiber optics (direct visualization probe), and prototype needle based confocal laser-induced…
- Trial name
- NCT01447238
- Testing
- Direct visualization and needle based confocal laser-induced endomicroscopy miniprobe
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of California, Irvine
Pleural Carcinomatosis
Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Malignancies Diagnosis.
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies").
- Trial name
- NCT03805971
- Testing
- Study of the pleural cavity with a confocal laser endomicroscope.
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University of Liege
Bladder Cancer, CLE
Confocal Laser Endomicroscopy During TransUrethral Resection for Improving BC Diagnosis and Treatment
A prospective monocenter diagnostic accuracy study of Confocal Laser Endomicroscopy (CLE) for Bladder Cancer(BC) to assess two primary objectives: 1.
- Trial name
- CLETUR (NCT05273593)
- Testing
- Confocal Laser Endomicroscopy (CLE)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diarrhea
Confocal Laser Endomicroscopy (CLE) in Patients With Diarrhea
The main objective of this study is to determine the frequency of different gastrointestinal disorders as the cause of diarrhea in patients at a tertiary referral center using confocal laser endomicroscopy.
- Trial name
- NCT01072110
- Testing
- Colonoscopy, Confocal Laser Endomicroscopy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Prostate Cancer
Focal Prostate Imaging With CLE and OCT
The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging…
- Trial name
- FPI (NCT03253458)
- Testing
- Confocal Laser Endomicroscopy
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cutaneous Lupus Erythematosus
Efficacy of Topical Tacrolimus in Different Subtypes With Cutaneous Lupus Erythematosus (CLE)
The purpose of this study is to evaluate the efficacy of topical tacrolimus in different subtypes of cutaneous lupus erythematosus.
- Trial name
- NCT00317681
- Testing
- Tacrolimus ointment
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Interstitial Lung Disease (ILD)
Confocal Laser Endomicroscopy Guided Cryobiopsy in the Diagnosis of Interstitial Lung Disease
This prospective, single-center, randomized controlled trial compares pCLE-guided TBLC with conventional TBLC in patients with suspected interstitial lung disease.
- Trial name
- NCT06741826
- Testing
- pCLE-guided transbronchial lung cryobiopsy, Fluoroscopy-guided transbronchial lung cryobiopsy
- Where
- China
- Volunteers
- 430 people
- Sponsor
- China-Japan Friendship Hospital
MLD, Krabbe Disease
Longitudinal Study of Neurodegenerative Disorders
The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the…
- Conditions
- MLD, Krabbe Disease, ALD, MPS I
- Trial name
- NCT03333200
- Testing
- Palliative Care, Hematopoetic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pittsburgh
Complication of Diagnostic Procedure, Adverse Effect of Diagnostic Agents, Subsequent Encounter
Dual Focus NBI and pCLE in FAP Related Duodenal Adenoma
Background: Familial adenomatous polyposis (FAP) patients are at risk to develop periampullary and non-ampullary adenoma. Either a routine biopsy or an endoscopic removal of the lesion is generally required to identify the…
- Trial name
- PIVI (NCT02162173)
- Testing
- Endoscopy
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Rectal Cancer
Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy.
- Trial name
- NCT05316103
- Testing
- Probe-based confocal laser endomicroscopy targeted optical biopsy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Cutaneous Lupus Erythematosus
Deep Phenotyping of Cutaneous Lupus Erythematosus
Cutaneous lupus erythematosus (CLE) is an autoimmune disease of which the pathogenesis and pathophysiology are not fully understood.
- Trial name
- NCT06411106
- Testing
- IMIQUIMOD cream 50mg/g
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Gastric Cancer
Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7-Ag
The study aims to: 1. Achieve molecular imaging of MG7 antigen in patients with gastric cancer in vivo using confocal laser endomicroscopy. 2.
- Trial name
- NCT01366586
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shandong University
Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus
A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Participants With Cutaneous Lupus Erythematosus (CLE)
The primary purpose of this study is to evaluate the efficacy, safety, and tolerability of IMVT-1402 in participants with Cutaneous Lupus Erythematosus.
- Trial name
- NCT06980805
- Testing
- IMVT-1402
- Where
- 86 sites in United States, Argentina and 11 more
- Volunteers
- 56 people
- Sponsor
- Immunovant Sciences GmbH