Clinical trials: COPD - Chronic Obstructive Pulmonary Disease
COPD, ILD
Recognition of Early Pulmonary Structural Changes by Using Real-time High Fidelity Expiratory CO2 Analysis
In this study the investigators aim to detect and characterize structural airway and lung vessel changes due to COPD or ILD as assessed by real-time high fidelity expiratory CO2 analysis.
- Trial name
- NCT05092035
- Testing
- single high-fidelity expiratory CO2 analysis
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Obstructive Pulmonary Disease
AZD9668 Relative Bioavailability
The study is designed to investigate the pharmacokinetic behaviour of the free base formulation of AZD9668. The study will compared the relative bioavailability of the free base formulation at two different dose levels compared…
- Trial name
- NCT01034982
- Testing
- AZD9668
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Lung Tissue Research Consortium
The LTRC will facilitate histopathological research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the LTRC.
- Trial name
- LTRC (NCT02988388)
- Testing
- Lung biopsy/lobectomy
- Where
- 4 sites in United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease (COPD)
Translating The GOLD COPD Guidelines Into Primary Care Practice
This project will evaluate the translation of the Gold (the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease) COPD guidelines into primary care practice.
- Trial name
- LungAge (NCT01237561)
- Testing
- provider support tools plus spirometer
- Where
- United States
- Volunteers
- 3,593 people, healthy volunteers welcome
- Sponsor
- Memorial Hospital of Rhode Island
COPD
Analyse the Correlation Between sEMG and EMGdi
The most significant pathophysiology change of COPD patients is persistent incompletely reversible airflow obstruction and increased lung volume. As a result, the work of breathing(WB) and neural respiratory drive (NRD)increased.
- Trial name
- NCT03268616
- Testing
- inspiratory threshold load device and NPPV
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Healthy Volunteers, Pathologies for Which paCO2 Monitoring is Crucial, Particularly in the Context of Chronic Obstructive Pulmonary Disease (COPD)
Influence of Temperature on Transcutaneous Blood Gas Diffusion: CAPNOS Project
The measurement of tcpCO2 has many disadvantages: the need for regular calibration (4 to 8 hours) of the sensor, the fact that the sensor heats the skin (risk of burns), the impossibility of measurement in ambulatory and the high…
- Trial name
- CAPNOS (NCT05637138)
- Testing
- tcpCO2 measure, tcpO2 measure, measurement of tissue conductivity to CO2: KS
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Pulmonary Adaptive Responses to HIIT in COPD
Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death.
- Trial name
- COPDEX0 (NCT05552833)
- Testing
- High intensity interval training
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Obstructive Lung Disease, Respiratory Ilness
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without…
- Conditions
- Chronic Obstructive Lung Disease, Respiratory Ilness, Estrogen Deficiency, Asthma
- Trial name
- ESSENTIAL (NCT06713512)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COPD, Pulmonary Disease
Effect of Self-directed and Supervised Pulmonary Rehabilitation Approach on Cough and Sputum.
Chronic obstructive pulmonary disease (COPD)is a multifactorial, progressive chronic lung disease that causes airflow restriction.
- Trial name
- NCT05538975
- Testing
- Physiotherapy Treatment
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Afridi Medical Complex
Smoking, Airway Obstruction
Effect of the Salbutamol on Mechanical Properties of Respiratory System
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
- Trial name
- NCT01521572
- Testing
- Salbutamol sulphate
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Chronic Obstructive Pulmonary Disease
Prevalence of Chronic Obstructive Pulmonary Disease in the Portuguese Population
The EpiCOPDpt Study (Prevalence of Chronic Obstructive Pulmonary Disease in the Portuguese Population) primary objective is to estimate the prevalence of Chronic Obstructive Pulmonary Disease (COPD) in the Portuguese population…
- Trial name
- EpiCOPDpt (NCT06523257)
- Testing
- Spirometry
- Volunteers
- 8,589 people, healthy volunteers welcome
- Sponsor
- Sociedade Portuguesa de Pneumologia
Lung Disease, Chronic Obstructive, Lung Disease, Interstitial
Detection and Characterization of Pulmonary Disease by Transthoracic Doppler (TTD)
The study seeks to characterize data obtained from patients with a variety of lung diseases using ultrasound Doppler signals obtained from lung tissue.
- Trial name
- NCT01618721
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Echosense Ltd.
Chronic Obstructive Pulmonary Disease, COPD
Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer
Lung cancer, largely the result of cigarette smoking, is the leading cause of cancer death in the United States, killing over 160,000 people in 2010, more than breast, colorectal, and prostate cancer combined.
- Trial name
- NCT01982149
- Testing
- Group 1, Group 2, Group 3
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Respiratory Diseases, Cystic Fibrosis
Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases
Assessment of cardiovascular disorders using echocardiography and arterial stiffness; comparative noninvasive assessment of volatile organic compound (eVOC) exhale breath patterns in patients with different chronic respiratory…
- Conditions
- Chronic Respiratory Diseases, Cystic Fibrosis, Lymphangioleiomyomatosis, Hypersensitivity Pneumonitis
- Trial name
- NCT05727852
- Testing
- Breath test using the Compact PTR-TOF-MS, Portable cardiac monitor "CardioQvark", Assessment of arterial stiffness using the VaSera VS-1500N
- Where
- Russia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COPD
Chronic Obstructive Pulmonary Disease (COPD) History Assessment In SpaiN (CHAIN)
The research project CHAIN (COPD Assessment History in Spain): "A Multidimensional Study on the Evolution of Chronic Obstructive Pulmonary Disease (COPD)is a multicentre, observational study conducted in several areas of Spain…
- Trial name
- CHAIN (NCT01122758)
- Where
- 2 sites in Spain
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Cimera
Obstructive Sleep Apnea
Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA
The purpose of study is to evaluate the physiologic effects of pulmonary tissue/structural changes associated with COPD and upper airway inflammation on upper airway collapsibility.
- Trial name
- NCT02567448
- Testing
- Sleep and pulmonary physiologic measurements
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Chronic Obstructive Pulmonary Disease
GIRH Chronic Obstructive Pulmonary Disease Observational Study
The purpose of this study is to establish the large COPD cohort and biological database in China, aiming for precision medicine to optimize diagnosis and treatment choices.
- Trial name
- NCT03893409
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- zili zhang
Cough, COPD
Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease
This study pretends to evaluate the potential use of Hyfe Cough Tracker (Hyfe) to screen for, diagnose, and support the clinical management of patients with respiratory diseases, while enriching a dataset of disease-specific…
- Conditions
- Cough, COPD, GERD, Asthma
- Trial name
- NCT05042063
- Testing
- Hyfe Cough Tracker, Hyfe Air
- Where
- Spain
- Volunteers
- 616 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Chronic Obstructive Pulmonary Disease, Emphysema
Macrophage Phagocytosis in COPD
Patients with chronic obstructive pulmonary disease (COPD) that have frequent chest infections are the patients most likely to become worse over time. Why these people are more susceptible to chest infections is not known.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00298389
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD, Smoking
Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation.
- Conditions
- COPD, Smoking, Lung Disorder
- Trial name
- NCT02341326
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University