Clinical trials: CRC
Safety and Efficacy of Tattooing Substance
Endoscopic Tattooing and Colorectal Cancer
Endoscopic tattooing to facilitate colorectal lesions' identification during laparoscopic surgery is a reliable and widely used technique. India Ink is the standard option for colonic tattoing.
- Trial name
- NCT03637933
- Testing
- endoscopic tattooing
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Colorectal Cancer, Advanced Adenocarcinoma
A Multicenter Clinical Trial of Stool-based DNA Testing for Early Detection of Colon Cancer in China
According to data from Global Cancer Statistics 2018, colorectal cancer (CRC) ranks second in incidence and fifth in mortality among all cancers in China.
- Conditions
- Colorectal Cancer, Advanced Adenocarcinoma, Hyperplastic Polyp, Colorectal Neoplasms
- Trial name
- NCT04722055
- Testing
- Multigene Methylation Detection Kit
- Where
- China
- Volunteers
- 1,273 people, healthy volunteers welcome
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
Metastatic Colorectal Carcinoma
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer
The aim of this work is to assess the antitumor effect of Pentoxiphylline in patients with metastatic colorectal cancer receiving stomatal chemotherapy ± targeted therapy.
- Trial name
- CRC - PTX (NCT06115174)
- Testing
- Pentoxifylline, FOLFOX, XELOX
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tanta University
Colorectal Cancer
Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects
This study is to investigate the effect of various modified low volume polyethylene glycol (PEG) 3350 and ascorbic acid/ascorbate (PEG+ASC)-based gut cleansing solutions on stool output in healthy subjects.
- Trial name
- OUT (NCT01834742)
- Testing
- NER1006, Moviprep
- Where
- 2 sites in Romania
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Norgine
Metastatic Colorectal Cancer
Efficacy of FOLFOX+Bevacizumab in Combination With Irinotecan in the Treatment of Metastatic Colorectal Cancer
The primary objective of this study is to evaluate the efficacy of Irinotecan in combination with FOLFOX+Bevacizumab versus FOLFOX+Bevacizumab alone in the first-line treatment of patients with metastatic colorectal cancer.
- Trial name
- CHARTA (NCT01321957)
- Testing
- Oxaliplatin, 5FU/LV, Bevacizumab, 5FU/LV, Oxaliplatin, Bevacizumab, Irinotecan
- Where
- 51 sites in Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Colorectal Neoplasms
Evaluating a Preference-based Intervention for Increasing Colorectal Cancer Screening
The goal of this study is to evaluate whether an educational tool about colorectal cancer (CRC) completed on a computer that helps patients clarify their CRC screening preferences will lead to increased screening rates for CRC…
- Trial name
- EPIIC (NCT00810771)
- Testing
- Standard Information, Preference-tailored Information
- Where
- 2 sites in United States
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Colorectal Neoplasms, Early Detection of Cancer
Impact of SMS Messaging on Participation in Colorectal Cancer Screening
Colorectal cancer is a leading cause of mortality in Catalonia. Although early detection programs using the fecal immunochemical test (FIT) are effective in reducing both incidence and mortality, their success relies on high…
- Trial name
- NCT07628998
- Testing
- Text Messaging, Standard invitation and postal reminder letters
- Where
- Spain
- Volunteers
- 10,084 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Colon Cancer, Bowel Cancer
Clinical Study to Establish the Feasibility and Usability of the EndoRings™
The purpose of this prospective clinical study is to establish the feasibility and usability of the ENDORINGS™ when used during standard colonoscopy procedure.
- Conditions
- Colon Cancer, Bowel Cancer, Colorectal Cancer
- Trial name
- NCT01868971
- Testing
- EndoRings
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- EndoAid
Colorectal Cancer, CRC
Colon Health Champion Program
This is a single arm-proof-of-concept trial. The primary goal of this trial is to assess the feasibility and acceptability of the Colon Health Champion Program
- Trial name
- NCT07796334
- Testing
- Intervention Arm: Colon Health Champions (CHC) Program
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Colorectal Cancer Screening
Pilot Study of the National Colorectal Cancer Roundtable Toolbox (NCCRT) to Increase Colorectal Cancer Screening Rates
The American Cancer Society and The Centers for Disease Control and Prevention in collaboration with The National Colorectal Cancer Roundtable published "How to Increase Colorectal Cancer Screening rates in Practice: A Primary…
- Trial name
- NCT00503737
- Testing
- National Colorectal Cancer Roundtable Toolbox
- Where
- United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Colorectal Carcinoma
Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia
This clinical trial compares audio brochures and video brochures to usual care for increasing colorectal cancer (CRC) screening among adults living in Appalachia.
- Trial name
- NCT05810714
- Testing
- Best Practice, Fecal Immunochemical Test, Health Education
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colo-rectal Cancer
EXercise And Colo-Rectal Cancer Trial
The aim of this study is to assess the feasibility and effectiveness of a home-based walking and strengthening intervention on physiological, biochemical and psychological outcomes in colo-rectal cancer survivors.
- Trial name
- EXACT (NCT02607787)
- Testing
- Exercise, Control
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Breast Cancer, Prostate Cancer
Collection of Blood Specimens for Circulating Tumor Cell Analysis
Objective: To test the sensitivity of a proprietary novel filtration device designed to capture and concentrate circulating tumor cells (CTCs).
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT01943500
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Viatar LLC
Cancer
Oligogenic Determinism of Colorectal Cancer
The majority of the clinical situations suggestive of an increased genetic risk for colorectal cancer (CRC) are not explained by a simple monogenic model.
- Trial name
- DOCC (NCT01057953)
- Testing
- Blood drawn
- Where
- 16 sites in France
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Colorectal Cancer, Colorectal Cancer Stage I
Web-based Learning Module on Optical Diagnosis of Early Colorectal Cancer
International guidelines recommend deciding the treatment of colorectal lesions based on the estimated histology by endoscopic optical diagnosis.
- Trial name
- LODIP (NCT05663788)
- Testing
- E-learning module
- Where
- 12 sites in United States, Japan and 2 more
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Gastric Cancer, Non-small Cell Lung Cancer
Clinical Study to Compare the Pharmacokinetics and Safety of Ramucirumab Injection With Cyramza ® in Healthy Male Volunteers
Ramucirumab is a biosimilar drug of CYRAMZA® produced by Chiatai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., LTD. It is a vascular endothelial growth factor receptor 2 (VEGFR-2) antagonist.
- Conditions
- Gastric Cancer, Non-small Cell Lung Cancer, Colo-rectal Cancer
- Trial name
- NCT05800418
- Testing
- Ramucirumab Injection, Ramucirumab Injection [Cyramza]
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Cervical Cancer, Breast Cancer
Using Effective Provider-Patient Communication to Improve Cancer Screening Among Low Literacy Patients
What's the purpose of this study? This 4-year study is designed: (1) to teach primary care physicians how to recognize low health literacy patients and effectively counsel them on cancer screening using risk communication and…
- Conditions
- Cervical Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT01361035
- Testing
- Cancer risk communication skills training
- Where
- 5 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Medicine
Colorectal Cancer
Effectiveness of Fecal Immunnochemical Test and Colonoscopy Screening in Hong Kong
Colorectal neoplasm in Asia is now increasingly common and is rising in an alarming manner in Hong Kong. Population-based screening for colorectal cancer (CRC) should be implemented.
- Trial name
- NCT03597204
- Testing
- Fecal immunochemical test (FIT), Colonoscopy
- Where
- Hong Kong
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer
Performance of NER1008 Enema Compared With Fleet® Enema in Bowel Cleansing
In order for flexible sigmoidoscopy to be a successful screening procedure, the bowel must be free of solid matter so the endoscopist has a clear view, increasing the chance of detection of abnormalities.
- Trial name
- NCT02468726
- Testing
- NER1008 enema, Fleet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Norgine
Colorectal Cancer, Adenomatous Polyps
Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed multitarget FIT-DNA Colorectal Cancer (CRC) screening test (ColoClear) for detecting advanced neoplasia (including colorectal…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- CLEAR-C (NCT04287335)
- Testing
- Multitarget stool FIT-DNA test - ColoClear, FIT, Colonoscopy
- Where
- 8 sites in China
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- Zhejiang University