Clinical trials: CRC
Colorectal Cancer
Gut Microbiome and Colorectal Cancer
Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries.
- Trial name
- NCT06748339
- Testing
- no intervention
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Heliopolis University
Colorectal Cancer
Rural Indiana Screening for Colorectal Cancer
The goal of this implementation study is to support an evidence-based intervention to the improve colorectal cancer (CRC) screening and diagnostic colonoscopy rates in rural Indiana.
- Trial name
- RISCC (NCT06133439)
- Testing
- Colorectal Screen rates with implementation of evidence-based intervention
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Neoplasms
A Study of Irinotecan With Dabrafenib Plus Trametinib and Anti-EGFR in the Second Line of Therapy in People With Metastatic Colorectal Cancer
The purpose of this study is to evaluate the efficacy and toxicity of irinotecan with dabrafenib, cetuximab/panitumumab in the second line of treatment for the potential treatment of colorectal cancer that: has a metastatic…
- Trial name
- NCT06967155
- Testing
- • Drug: Dabrafenib • Drug: Trametinib • Drug: Cetuximab • Drug: Рanitumumab • Drug: Oxaliplatin • Drug: Irinotecan • Drug: Leucovorin • Drug: 5-FU
- Where
- Russia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Blokhin's Russian Cancer Research Center
Hepatocellular Cancer, Non-small Cell Lung Cancer
Profile of Soluble and Cellular Biomarkers and of Functional Imaging During Antiangiogenic Therapies in Cancer Patients
Tumour angiogenesis has been identified to play a critical role in tumour growth and this knowledge has led to the identification of new targets for cancer therapy.
- Conditions
- Hepatocellular Cancer, Non-small Cell Lung Cancer, Renal Cell Cancer, Colorectal Cancer
- Trial name
- NCT01507740
- Testing
- Avastin, Suntent, Nexavar
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Sessile Serrated Adenoma, Colorectal Polyp
Assessing the Agreement Between Endoscopic and Histopathological Diagnosis of Colorectal Sessile Serrated Lesions.
The goal of this observational study was to assess the degree of agreement between the endoscopic and anatomopathological diagnosis of sessile serrated colorectal lesions in adult patients undergoing colonoscopy in Hospital…
- Conditions
- Sessile Serrated Adenoma, Colorectal Polyp, Adenoma Colon, Colorectal Cancer
- Trial name
- NCT06173297
- Where
- Brazil
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Colorectal Cancer
Comparing the Effectiveness of Written Vs Verbal Advice for First Degree Relatives of Colorectal Cancer Patients
CRC patients were enrolled and asked about their FDR contacts These FDRs were telephoned and enrolled and randomized to receive either written advice and verbal advice about their cancer risk and screening methods.
- Trial name
- NCT06242197
- Testing
- written advice
- Where
- Thailand
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Colorectal Cancer
Increasing Uptake of Bowel Screening
Bowel cancer is the second biggest cancer killer in the UK, accounting for over 16,000 deaths per year. Screening can reduce deaths from bowel cancer if the people invited participate.
- Trial name
- TEMPO (NCT05408169)
- Testing
- Suggested deadline for return of screening test, Planning sheet
- Where
- United Kingdom
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Colorectal Cancer, Surgery
Microbiota Implementation to Reduce Anastomotic Colorectal Leaks (MIRACLe)
Aim of this study is to implement the intestinal microbiota by perioperative administration of probiotics, oral antibiotics and low volume mechanical preparation in order to reduce the incidence of colorectal anastomotic leaks…
- Conditions
- Colorectal Cancer, Surgery, LAP, Anastomotic Leak
- Trial name
- MIRACLe (NCT05164887)
- Testing
- Laparoscopic colorectal resection
- Where
- Italy
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- S.Eugenio Hospital
Colorectal Cancer
Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep
This study will be comparing patient satisfaction, efficacy comparing miralax with gatorade versus Movi Prep for outpatient colonoscopy.
- Trial name
- NCT01695863
- Testing
- comparing 2 drugs on their effect on the bowel preparation for colonoscopy
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Adenoma, Colo-rectal Cancer
A Dual Tandem Study - SC vs. CAD-EYE vs. CAD-EYE With G-EYE
Single-center, four-arm dual-tandem, randomized, open-label study involving the following devices: 1. The Standard Colonoscope is a high-definition colonoscope employing advanced optical filtering and enhancement techniques …
- Trial name
- NCT05318495
- Testing
- Standard Colonoscopy, CAD-EYE, G-EYE
- Where
- Germany
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Colorectal Cancer
Preventive Strategies in Colorectal Carcinogenesis Production and Meat Processing
Colorectal Cancer is, in non-smokers for both sex, first cause of cancers mortality in Western country. The main risk factors associated with colorectal cancer depend of lifestyle, and processed meat and red meat could be…
- Trial name
- NCT02473302
- Testing
- ham, ham + pomegranate extract, ham + tocopherol
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Cancer
Clinical Study of Pan-cancer DNA Methylation Test in Plasma
We intend to establish an efficient method for plasma cfDNA extraction and Bisulfite transformation to facilitate the detection of DNA methylation status using multiplex fluorescence PCR.
- Trial name
- NCT05685524
- Testing
- DNA methylation test
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Wuhan Ammunition Life-tech Co., Ltd
Healthy
Patients Navigator for Organized Colorectal Cancer Screening
The main objective is to evaluate the impact of the recruitment and training of a peer-navigator on the participation rate of colorectal cancer screening among underserved area.
- Trial name
- COLONAV (NCT02369757)
- Testing
- Navigator intervention
- Where
- France
- Volunteers
- 40,774 people, healthy volunteers welcome
- Sponsor
- Institut de Cancérologie de la Loire
ColoRectal Cancer
Community Engaged Colon Cancer Screening Patient Navigator Program
The goal of the project is to increase colorectal cancer screening within the priority population of female and male adults age 50 to 85 in Northern Nevada.
- Trial name
- NCT03031171
- Testing
- Screening patient navigation, Non-Navigated
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Colorectal Neoplasms
Colorectal Cancer Associated Host and Microbiome Study
Recruit of healthy, precancer and colorectal cancer patients and record necessary information of demographic and also other messages. All the volunteers were asked to provide samples including stool, blood, urine and tissues.
- Trial name
- NCT03998644
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Colo-rectal Cancer, Cancer Colon
AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test
Freenome is using a type of artificial intelligence, called machine learning, to identify patterns of cell-free biomarkers in blood to detect cancer early.
- Conditions
- Colo-rectal Cancer, Cancer Colon, Cancer, Rectum, Neoplasms,Colorectal
- Trial name
- NCT03688906
- Where
- 30 sites in United States, Canada
- Volunteers
- 3,275 people, healthy volunteers welcome
- Sponsor
- Freenome Holdings Inc.
Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners
This pilot clinical trial studies how well acceptance and commitment therapy works in improving well-being in patients with stage III-IV cancer and their partners.
- Conditions
- Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm, Partner, Stage III Breast Cancer
- Trial name
- NCT03112668
- Testing
- Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Adenoma, Polyps
Prospective Trial to Compare the Clinical Efficiency of G-EYE™ HD Colonoscopy With Standard HD Colonoscopy
The purpose of this study is to compare the adenoma detection rate of G-EYE™ high definition colonoscopy with that of standard high definition colonoscopy
- Conditions
- Adenoma, Polyps, Colorectal Cancer
- Trial name
- NCT01917513
- Testing
- G-EYE™ colonoscopy, Standard Colonoscopy
- Where
- 15 sites in United States, Denmark and 6 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Colonic Neoplasms
Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation
A quality colonoscopy examination remains as the gold standard for colorectal cancer screening, but effective large bowel cleansing prior to colonoscopy is still not achieved in all cases that undergo the procedure.
- Trial name
- NCT01547130
- Testing
- Normal (0.9%) saline, HalfLytely
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Arya, Vijaypal, M.D., P.C.
Colorectal Cancer Screening
Increasing Primary Care Physician Colorectal Cancer Screening Rates
The purpose of the study is to determine if a Web-based intervention increases physician rates of colorectal cancer recommendation rates in a group of physicians participating in the American Board of Internal Medicine's…
- Trial name
- NCT00955344
- Testing
- eToolbox, no link to eToolbox
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania