Clinical trials: CVA, open to volunteers
Ischemic Stroke, Stroke
Clinical Evaluation of EEG Device for the Triage of Stroke Patients in the Ambulance
Endovascular thrombectomy (EVT) is the standard treatment for large vessel occlusion (LVO) strokes, but it can only be performed in specialized hospitals.
- Conditions
- Ischemic Stroke, Stroke, Cardiovascular Diseases, Vascular Diseases
- Trial name
- CROSSROADS-EEG (NCT06871969)
- Testing
- Dry electrode EEG
- Where
- Netherlands
- Volunteers
- 275 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ischemic Stroke, Ischemic Cerebrovascular Disease
Clinical Evaluation of New Biomarkers for Ischemic Cerebrovascular Disease
The goal of this single-center prospective observational study is to identify and evaluate new biomarkers for ischemic cerebrovascular disease (ICVD) to aid in early diagnosis, individualized treatment planning, and prognosis…
- Trial name
- NCT06890702
- Testing
- biomaker levels
- Where
- 2 sites in China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Healthy, Stroke
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands.
- Conditions
- Healthy, Stroke, Normal Physiology, Aging
- Trial name
- NCT03288220
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Get With the Guidelines-Stroke Registry
Get With The Guidelines-Stroke is a program for improving the quality of care for patients hospitalized with stroke by promoting consistent adherence to the latest evidence-based clinical practice guidelines.
- Trial name
- GWTG-Stroke (NCT02693223)
- Testing
- GWTG Stroke program
- Where
- United States
- Volunteers
- 3,892,063 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Motor Recovery
BreEStim for Post-Stroke Motor Recovery
The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with…
- Trial name
- NCT04750551
- Testing
- BreEStim, EStim
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cadasil
AusCADASIL: An Australian Cohort of CADASIL
The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
- Trial name
- NCT06148051
- Where
- 5 sites in Australia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Perminder Sachdev
Stroke
Closed-loop Sensorimotor Integrated (CSMI) Control in Exoneuromusculoskeleton (ENMS) for Precise Wrist-hand Rehabilitation After Stroke
The goal of this randomized controlled trial is to determine whether using both brain and muscle signals to control a wrist-hand rehabilitation robot can improve recovery in people with chronic stroke.
- Trial name
- NCT07737431
- Testing
- CSMI-Controlled ENMS, EMG-Driven ENMS
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- The Hong Kong Polytechnic University
Acute Ischemic Stroke AIS, Stroke Acute
ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain has a prospective, randomized, controlled, open-label, parallel group with blinded endpoint assessment (PROBE) design.
- Conditions
- Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
- Trial name
- ACT-WHEN (NCT06320431)
- Testing
- Tenecteplase
- Where
- 24 sites in Australia, Canada
- Volunteers
- 4,000 people
- Sponsor
- University of Calgary
Subacute Stroke, Upper Extremity Function
AI-based Customized tDCS for Finger Motor Recovery After Subacute Stroke
The goal of this clinical study is to evaluate whether AI-based customized transcranial direct current stimulation (tDCS) using MR images is more effective than sham stimulation in improving finger motor function in patients with…
- Trial name
- NCT07491029
- Testing
- AI-based Customized transcranial Direct Current Stimulation
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- NEUROPHET
Acute Ischemic Stroke, Stroke-Associated Pneumonia (SAP)
Oropharyngeal Flushing Suction Tube With Laryngoscope for Stroke-Associated Pneumonia
Stroke-associated pneumonia is a common and clinically important complication after acute ischemic stroke, especially in non-intubated patients with impaired consciousness and reduced cough or swallowing reflexes.
- Trial name
- OFST-SAP (NCT07647666)
- Testing
- Oropharyngeal Flushing Suction Tube, Laryngoscope-Guided Oropharyngeal Suction, Standard Suction Catheter
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Pudong New Area Gongli Hospital
Stroke, Caregiver Burden
Efficacy and Sustainability of a Carepartner-Integrated Telerehabilitation Program for Persons With Stroke
Stroke is a leading cause of long-term disability. Research has placed little emphasis on integrating care partners (CP) (family members) into the rehabilitation process without increasing negative care partner outcomes.
- Trial name
- CARE-CITE (NCT06655402)
- Testing
- CARE-CITE, Attention Control Group, Actigraph GT3X+
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Emory University
Atrial Fibrillation
COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
Atrial Fibrillation (AF) affects 200,000 Canadians and increases risk of stroke, morbidity and mortality. Having a stroke can affect a patient's ability to speak, eat, walk, work, care for themselves, and interact with others.
- Trial name
- COBRRA-AF (NCT04642430)
- Testing
- Apixaban, Rivaroxaban
- Where
- 8 sites in Canada
- Volunteers
- 3,018 people
- Sponsor
- Ottawa Hospital Research Institute
Atrial Fibrillation (AF)
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly.
- Trial name
- ROXI-ATLAS (NCT07175428)
- Testing
- REGN7508, REGN9933, Apixaban
- Where
- 89 sites in United States, Argentina and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Regeneron Pharmaceuticals
Stroke
A Mobile Brain/Body Imaging Platform for the Assessment and Optimization of Post-stroke Overground Robotic Gait Treatments
The study aims to identify neural biomarkers that can be used to monitor the recovery of locomotion and movement of post-stroke patients, both in natural settings and with enriched treatment using robotic device.
- Trial name
- COBI (NCT07510633)
- Testing
- overground wearable robotic device
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Franco Molteni
Lower Limb; Sprain (Strain), Lower Limb Fracture
Implementation of an App-based Walking Aid Skills Training Program
Walking aids (WA), such as crutches, canes, and walkers allow individuals to move independently after lower body impairment. Improper WA use may lead to upper body discomfort, pain, or injury.
- Conditions
- Lower Limb; Sprain (Strain), Lower Limb Fracture, Stroke, Multiple Sclerosis
- Trial name
- NCT05347875
- Testing
- Walking aid skills app, Breathing skills app
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Atrial Fibrillation, Stroke
AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial
We hypothesize that an AI-guided AF risk stratification approach, particularly when combined with intensified rhythm monitoring using wearable devices and extended ECG patches, will significantly increase AF detection rates…
- Conditions
- Atrial Fibrillation, Stroke, Artificial Intelligence
- Trial name
- AI-AFIS (NCT07540065)
- Testing
- Active Follow-up Group, Standard Follow-up Group
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Stroke, Ischemic, Thrombectomy
Prognostic Value of Isolated and Combined Score Aspects in Acute Ischemic Stroke
This study, called TARGET-ASPECT, looks at patients who had a type of stroke called acute ischemic stroke and were treated with clot-busting medicine and a procedure to remove the clot.
- Conditions
- Stroke, Ischemic, Thrombectomy, Thrombolytic Therapy, Brain Ischemia
- Trial name
- NCT07069452
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier de Gonesse
Stroke Patients With Hemiplegia or Hemiparesis in the Subacute Stage
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke)
The goal of this study is to evaluate the effects of high frequency tPCS + TENS compared to Sham device stimulation + TENS (Control) in lower limb motor function recovery in stroke patients with hemiplegia or hemiparesis in the…
- Trial name
- COMPENSATOR (NCT06999876)
- Testing
- The AscenZ-VIII Stimulator (Investigational Medical Device)
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- National University Health System, Singapore
Stroke
Potential for Recovery of Voluntary Finger Extension After Stroke
Stroke patients with absent voluntary finger extension (VFE) 6-months after stroke are not expected to recover hand function. However, experience from the Queen Square Upper Limb neurorehabilitation service contradicts this view.
- Trial name
- PROVES (NCT07592247)
- Testing
- Neuromuscular Electrical Stimulation and Home Exercise Programme
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
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