Clinical trials: CVC
Central Venous Cather Position
Assessing Validity of M-Mode Time-to-Turbulence "T2T" Echo Use to Confirm CVC Tip Position
Using an ultrasound echocardiography , we will measure the time to turbulance "T2T" from injecting saline into the central venous catheter CVC to the appeareance of turbulance on the screen using an MMode.
- Trial name
- NCT03058445
- Testing
- Echocardiography, CVC
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Social Anxiety Disorder
CvC-SAD (Clinician vs Coach)Self-help Versions in a RCT
Background: Social Anxiety Disorder (SAD) is a common mental problem, where people experience severe and disabling anxiety about social situations and interactions.
- Trial name
- NCT05292612
- Testing
- iCBT(C&W) for SAD
- Where
- Hong Kong
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and Pioglitazone, When Dosed Alone or in Combination
A single center, open-label, fixed sequence study to evaluate the pharmacokinetics (PK) of Cenicriviroc (CVC) administered with and without Pioglitazone (PGZ), and to evaluate the PK of PGZ administered with and without CVC.
- Trial name
- NCT02342067
- Testing
- Cenicriviroc, Pioglitazone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
HIV-infection/AIDS
Study of Dolutegravir (DTG) on PK of Cenicriviroc (CVC), and CVC on PK of DTG & on a Single Dose of Midazolam
To evaluate the PK, safety and tolerability of Cenicriviroc (CVC) administered with and without Dolutegravir (DTG) and CVC with and without a single dose of Midazolam in healthy subjects.
- Trial name
- NCT01827540
- Testing
- Cenicriviroc, Dolutegravir, Midazolam
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
This is a Phase 1, Open-Label, 3-Period, Single-sequence, Drug-drug Interaction Study in Healthy Subjects to Assess the Effect of Cenicriviroc on the Pharmacokinetics (PK) of HMG-CoA Reductase Inhibitors [Rosuvastatin (ROS)…
- Trial name
- NCT02685462
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Liver Insufficiency
Phase 1 Study of Multiple-Dose Pharmacokinetics of Cenicriviroc in Subjects With Mild and Moderate Hepatic Impairment
To determine whether CVC exposures are altered in subjects with impaired hepatic function, compared to subjects with normal hepatic function.
- Trial name
- NCT02120547
- Testing
- Cenicriviroc in mild liver impaired, Cenicriviroc in moderate liver impaired
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Cancer Patients, Central Venous Catheter Thrombosis
Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) in Cancer Patients
Cancer patients with Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) will be treated with Low Molecular Weight Heparin (LMWH) and apixaban. Study duration is 12 weeks.
- Conditions
- Cancer Patients, Central Venous Catheter Thrombosis, Upper Extremity Thrombosis
- Trial name
- NCT03100071
- Testing
- Apixaban
- Where
- 2 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Michael Kovacs
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and Acid Reducing Agents When Dosed Alone or in Combination
This is a Phase 1, Single and Multiple-Dose, Open-Label Study in Healthy Subjects to Assess the Effect of the Acid Reducing Agents, Omeprazole and Famotidine, on the PK of CVC
- Trial name
- NCT02684799
- Testing
- Cenicriviroc, Omeprazole, Famotidine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Nosocomial Infections
ED Residents MBP During CVC Placement: Sim Lab Based Training
1. Baseline performance in maximal barrier precaution technique of Emergency Medicine (EM) residents, certified in CVC placement, is poor 2.
- Trial name
- EM CVC MBP (NCT00791583)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Dysbiosis, Catheter-Related Infections
Cutaneous Microbiota Evolution in ICU Patients With CVC (ICMc)
Intensive Care Unit (ICU) patients are exposed to catheter-related infections with an important morbidity. Catheter colonization is constant but infection is not. Cutaneous dysbiosis could be the missing link.
- Trial name
- ICMc (NCT06095076)
- Testing
- Skin swabbing, Data collection
- Where
- French Guiana
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne