Clinical trials: Caffeine
HIV Infections
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
This is an open-label, single sequence study that is being conducted to investigate the potential drug-drug interaction (DDI) when GSK3640254 is co-administered with a cocktail of cytochrome P450 (CYP) enzymes and transporter…
- Trial name
- NCT04425902
- Testing
- GSK3640254 200 mg, Caffeine 200 mg, Metoprolol 100 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Caffeine, Affect
Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT
The purpose of this project is to examine the effect of expectancy on mood and alertness after consumption of caffeine "treatment" or placebo "control" pill, given that participants know their probability for receiving the…
- Conditions
- Caffeine, Affect, Cognitive Ability, General, Mood
- Trial name
- NCT02461693
- Testing
- Caffeine
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Caffeine
Caffeine, Resistance Exercise and EMG
Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance.
- Trial name
- NCT06606652
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Caffeine
The Effects of a Caffeine Supplement (UBrain) on Cognitive Fatigue After a Virtual Reality Drive Simulation
Motorsport drivers are now widely recognized as athletes in their own right, as they are required to cope with levels of physical and psychological stress comparable to those experienced in more conventional sports.
- Trial name
- NCT07852299
- Testing
- Caffeine supplement
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Padova
Obesity
"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
This study compares four treatments to see which one causes the most weight loss, fat loss, loss of abdominal fat and improvement in blood tests like cholesterol.
- Trial name
- NCT00377975
- Testing
- Ephedrine, Pioglitazone, Caffeine
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Sports Performance
Effects of L-Tyrosine and Caffeine on Performance in Elite Boxers
Participants will complete six sessions, including one familiarization and baseline session followed by five experimental conditions: control (no supplementation), placebo, L-tyrosine, caffeine, and combined L-tyrosine plus…
- Trial name
- TYCAF-BOX (NCT07530185)
- Testing
- L-Tyrosine, Caffeine, L-tyrosine + Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Inonu University
Fatigue, Tachycardia
Effect of Caffeine on Heart Function
The primary objective of this study is to assess the effect of an energy drink on ventricular repolarization as measured by the interval between the cardiac Q wave and the cardiac T wave (QT interval)obtained from the body…
- Trial name
- NCT02401776
- Testing
- Monster Energy Drink, Coffee
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Drug Mechanism, Metabolism Medication Toxicity
Pharmacology Space Kit (PSK) - Dried Blood Spot for Caffeine Pharmacokinetics Under Microgravity Conditions
The PSK study is preliminary to the study of drug metabolism in space flight conditions. The investigators propose to use simplified blood sampling methods that can be applied in microgravity.
- Conditions
- Drug Mechanism, Metabolism Medication Toxicity, Space Motion Sickness
- Trial name
- PSK (NCT06431984)
- Testing
- prick test
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cytochrome, Pharmacokinetics
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called "Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
- Trial name
- NCT01187862
- Testing
- caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Caffeine, Placebo
Caffeinated Chewing Gum on 400-meter Performance
20 trained sprinter were divided into caffeine Gum trial (CAF) and Placebo trial (PL) with a randomized, double-blind study design.
- Trial name
- NCT06430996
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chih-Hui Chiu
Cardiovascular Injury
Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers
The purpose of this study determine the difference in hemodynamic effects of synthetic and natural caffeine consumption in healthy individuals through blood pressure (central and peripheral) assessment.
- Trial name
- NCT03495063
- Testing
- Natural Caffeine, Synthetic Caffeine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Mental Fatigue
Effect of Phytochemicals From Theobroma Cacao on Mental Energy
The purpose of this study is to determine which substances in cocoa produces changes in mental energy. This is a double blind study.
- Trial name
- NCT01651793
- Testing
- Caffeinated cocoa, Cocoa, Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Healthy, Alcohol Drinking
Binge Drinking of Alcohol Mixed With Energy Drinks
The purpose of the study is to assess the relevance of gender in the acute effects (subjective, physiological and driving-related skills) observed after controlled administration of alcohol in a binge-drinking pattern mixed with…
- Trial name
- ENERGYBINGE (NCT04616859)
- Testing
- Alcohol and Energy Drink (AmED)
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
Cognitive Function and Memory
Cognitive Effects of a Dietary Supplement With PQQ, GABA, Caffeine, and B-Vitamins in Healthy Postmenopausal Women: A Randomized Controlled Trial
Various food supplements have been shown to improve cognitive function. However, there is limited data on the impact of these supplements on postmenopausal women.
- Trial name
- NCT06748989
- Testing
- Cortexium food supplement
- Where
- Hungary
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- FEMPHARMA Kft.
Dietary Supplement, Exercise
Coffee Increases Physical and Cognitive Performance Both in Men and Women
The impact of caffeine habituation on acute responses to different doses of caffeinated coffee has received minimal attention. This study aimed to investigate the effects of different doses of coffee on physical and cognitive…
- Trial name
- NCT07474753
- Testing
- Low Dose Caffeine (LCOF), Moderate Dose Caffeine (MCOF), High Dose Caffeine (HCOF)
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Caffeine
Caffeine Supplementation, Resistance Training and Blood Antioxidant Status
The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.
- Trial name
- NCT05230303
- Testing
- Caffeine supplementation
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Multiple Sclerosis, Stroke
An Assistive Powered Wheelchair: Stage 2 Trial
Preliminary evaluation of an obstacle alerting system to enhance the user's independent mobility by improving their confidence to drive and their safety in driving a powered wheelchair.
- Conditions
- Multiple Sclerosis, Stroke, Cystic Fibrosis, Motor Neurone Disease
- Trial name
- EDUCAT (NCT05292690)
- Testing
- Powered Wheelchair Obstacle Alerting System
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Caffeine, Placebo
Caffeine Supplementation Improves the Cognitive Abilities and Shooting Performance of Trained E-sports Players
Purpose: investigators explored the effect of 3 mg/kg of caffeine supplementation on the cognitive ability and shooting performance of trained e-sports players.
- Trial name
- NCT05521347
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Healthy Adults; Hematopoietic System; Caffeine
Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System
This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults. The trial will compare people who regularly consume caffeine with those who consume very little or none.
- Trial name
- CaffeineHSC (NCT07193264)
- Testing
- Caffeine (200 mg)
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jasmin Rettkowski
Sleep Deprivation, Caffeine
Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)
This clinical trial will be a comparison between personalized recommended caffeine dosing regimen versus the standard recommended caffeine dosing regimen for sustaining performance during sleep deprivation and minimizing side…
- Trial name
- 2B-2 (NCT05588934)
- Testing
- Caffeine Gum
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Arizona