Clinical trials: Caffeine-Related Disorders
Cognitive Performance
Assessing the Effectiveness of an N-of-1 Platform Using Study of Cognitive Enhancers
The growing consumer-grade molecular and digital wellness market is generating unprecedented volumes of information to support decision-making around individual health.
- Trial name
- NCT04056650
- Testing
- L-theanine, Caffeine supplement, N1 app
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Adolescent Idiopathic Scoliosis
Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion
Prospective, randomized control trial To determine if oral caffeine decreases the frequency of opioid demand in children with adolescent idiopathic scoliosis after their spinal fusion surgery To compare pain scale ratings, number…
- Trial name
- NCT04950660
- Testing
- Caffeine Tablet
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Children's Mercy Hospital Kansas City
Caffeine, Cellulitis
The Effects of Iontophoresis in Women With Gynoid Hidrolipodystrophy.
Introduction: Gynoid hydrolipodystrophy (HLDG) or cellulitis is a subcutaneous tissue disorder, with several strategies for its treatment, such as caffeine and iontophoresis.
- Trial name
- NCT03556917
- Testing
- iontophoresis + caffeine
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Norte do Paraná
Caffeine, Ischemic Preconditioning
The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion.
- Conditions
- Caffeine, Ischemic Preconditioning, Ischemia-Reperfusion Injury
- Trial name
- NCT00184912
- Testing
- caffeine, Technetium-TC99m-labeled Annexin A5, ten minutes forearm ischemia
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Caffeine, Fatigue
Effect of Caffeine Supplementation and Personalized Insoles on Females
Several studies have shown the positive effect that caffeine has on athletic performance related variables. Nonetheless, most studies have been developed in males and have not studied the possible effects on biomechanics and…
- Conditions
- Caffeine, Fatigue, Injuries, Females Xy
- Trial name
- NCT04642131
- Testing
- Caffeine supplementation, Personalized insoles, Control condition
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Nutritional Supplementation, Resistance Training
Caffeine and Sodium Bicarbonate Supplementation Effects on Resistance Training Performance
This research aims to explore the effects of two supplements, caffeine and sodium bicarbonate, on acute (short-term) resistance training performance.
- Trial name
- NCT06714331
- Testing
- Supplements
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
HIV Infections
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
This is an open-label, single sequence study that is being conducted to investigate the potential drug-drug interaction (DDI) when GSK3640254 is co-administered with a cocktail of cytochrome P450 (CYP) enzymes and transporter…
- Trial name
- NCT04425902
- Testing
- GSK3640254 200 mg, Caffeine 200 mg, Metoprolol 100 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Healthy, Caffeine
Effects of Energy Drinks on Sleep and Cardiovascular Health
The purpose of this study is to learn about the change in quality of sleep, structural organization of sleep, and cardiovascular responses after consuming an energy drink compared to a placebo drink with no caffeine or stimulants.
- Trial name
- NCT05503732
- Testing
- Energy Drink
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Skill Performance, Soccer Performance
Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players
This study of soccer skill performance has three objectives: 1. Compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision, passing speed and accuracy, and sprint speed during a full simulated…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT05547204
- Testing
- Beverage
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sleep Deprivation, Caffeine
Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)
This clinical trial will be a comparison between personalized recommended caffeine dosing regimen versus the standard recommended caffeine dosing regimen for sustaining performance during sleep deprivation and minimizing side…
- Trial name
- 2B-2 (NCT05588934)
- Testing
- Caffeine Gum
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Caffeine
Effects Of Caffeine On Cognitive Performance
Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills.
- Trial name
- NCT05995314
- Testing
- 3 mg/kg of caffeine, 6 mg/kg of caffeine
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Healthy Volunteers, Caffeine
Caffeine Dose: Performance and Recovery
The goal of this clinical trial is to learn how different doses of caffeine taken in the evening affect rowing performance, sleep quality, and daytime alertness in trained male university rowers.
- Conditions
- Healthy Volunteers, Caffeine, Sleep Quality
- Trial name
- NCT07090421
- Testing
- Cellulose Powder, Caffeine 3 mg/kg Oral Powder, Caffeine 6 mg/kg Oral Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ulaç Can YILDIRIM
Hemodynamic Instability, Skin and Subcutaneous Tissue Disorders
Non Invasive Measurement of the Haemodynamic Parameters and of the Advanced Glycation End Products (AGEs) Levels
The aim of this study was to investigate the difference in accumulation of AGEs (advanced glycation end-products) in the tissues of individuals who smoke in comparison with individuals who do not as well as of individuals who…
- Trial name
- NONINVASHEMO (NCT02544165)
- Testing
- caffeine intake, cigarette smoking, Caffeine intake and Cigarette smoking
- Where
- Greece
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Technological Education Institute of Sterea Ellada
Mental Fatigue
Effect of Phytochemicals From Theobroma Cacao on Mental Energy
The purpose of this study is to determine which substances in cocoa produces changes in mental energy. This is a double blind study.
- Trial name
- NCT01651793
- Testing
- Caffeinated cocoa, Cocoa, Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Fatigue
Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health
The purpose of this study is to assess the effectiveness and safety of the Alpinia galanga formulation, Theacrine formulation, and Caffeine formulation on fatigue, mental acuity, and cognitive health among overall healthy…
- Trial name
- NCT05170113
- Testing
- Alpinia galanga formulation, Theacrine formulation, Caffeine formulation
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Athletic Performance, Cognitive Performance
Effects of Different Doses of Caffeine on Physical and Cognitive Performance in Female Handball Players
This study investigates how different doses of caffeine affect physical and cognitive performance in female handball players. Caffeine is widely used as a performance-enhancing substance, but its effects may vary depending on the…
- Conditions
- Athletic Performance, Cognitive Performance, Healthy Adult Females
- Trial name
- NCT07562256
- Testing
- Caffeine 3 mg/kg, Caffeine 6 mg/kg
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sinop University
Healthy Adults; Hematopoietic System; Caffeine
Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System
This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults. The trial will compare people who regularly consume caffeine with those who consume very little or none.
- Trial name
- CaffeineHSC (NCT07193264)
- Testing
- Caffeine (200 mg)
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jasmin Rettkowski
Morbid Obesity
Treatment of Low Metabolic Rate Following Bariatric Surgery
Purpose is to determine the effect of ephedrine and caffeine, on metabolic rate and weight loss after bariatric surgery. Approximately 40% of patients struggle with their weight loss rate, or metabolic rate, after bariatric…
- Trial name
- NCT01596907
- Testing
- Ephedrine sulfate with caffeine, cellulose
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Oregon Weight Loss Surgery, LLC
Healthy Adults
Ketone Production With Acute Caffeine Intake
Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).
- Trial name
- NCT02694601
- Testing
- Control, Caffeine low dose, Caffeine high dose
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Beetroot Juice, Caffeine
Acute Effects of Beetroot Juice and Caffeine Co-ingestion on Lower-limb Strength and Muscular Endurance in Females
The aim of this study is to evaluate the acute effects of beetroot juice and caffeine, consumed individually or in combination, on lower-limb strength and muscular endurance in physically active women.
- Conditions
- Beetroot Juice, Caffeine, Placebo, Beetroot Juice with Caffeine Co-ingestion
- Trial name
- NCT06758323
- Testing
- Beetroot juice combined with caffeine (COM)
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Jose Manuel Jurado Castro