Clinical trials: Caffeine-Related Disorders
Healthy
Pre-workout Supplement Versus Caffeine on Energy Expenditure.
The primary purpose of this study was to examine the acute effects of a multi-ingredient pre-workout supplement versus an ergogenic dose of caffeine (6 mg/kg) on energy expenditure during low-intensity exercise.
- Trial name
- NCT04539054
- Testing
- ENGN Shred, Nutricost caffeine powder, Crystal Light
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northern Illinois University
Osteopenia (Disorder), Apnea of Prematurity
Effect of Caffeine on Preterm Infants' Bone Mineral Content
The primary objective was to determine whether caffeine therapy is associated with decreases bone mineral content using dual energy x-ray absorptiometry.
- Trial name
- NCT03084432
- Testing
- Dual Energy X-ray Absorptiometry
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Athletic Performance, Postural Stability
Effects of Caffeine and Nicotine Gum on Balance Performance in Athletes
This randomized, single-blind, placebo-controlled, four-condition crossover study evaluates the acute effects of caffeine gum (~3 mg/kg) and nicotine gum (4 mg) on balance performance in healthy, trained adults.
- Conditions
- Athletic Performance, Postural Stability, Healhty
- Trial name
- NCT07254832
- Testing
- Caffeine Gum 3mg/kg, Nicotine Gum (4 mg)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gülbin Rudarlı
Caffeine Use Disorder (DSM-5 Condition for Further Study)
Treatment for Caffeine Dependence
Recent research has shown that some individuals become addicted to or dependent on caffeine and are unable to quit or reduce caffeine consumption despite a persistent desire to do so.
- Trial name
- NCT01951872
- Testing
- Manual-based treatment for caffeine dependence
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Johns Hopkins University
Exercise Response
Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase Levels
The goal of this clinical trial is to investigate the effects of the mouth rinse form of caffeine (400 mg) on salivary lactoferrin, α-amylase and secretory immunoglobulin-a levels after incremental exercise in young amateur…
- Trial name
- NCT06704711
- Testing
- Caffeine 300 MG, Exercise
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Pharmacokinetics of Dextromethorphan, Pharmacokinetics of Caffeine
A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer
This study evaluates how once daily enzalutamide affects the metabolism of caffeine and dextromethorphan in men with prostate cancer by measuring concentrations of these drugs and their metabolites in plasma.
- Conditions
- Pharmacokinetics of Dextromethorphan, Pharmacokinetics of Caffeine, Prostate Cancer
- Trial name
- NCT02225093
- Testing
- Caffeine, Dextromethorphan, Enzalutamide
- Where
- Moldova
- Volunteers
- 12 people
- Sponsor
- Astellas Pharma Europe B.V.
Cancer-related Fatigue, Breast Cancer
Guaraná Supplementation for Cancer-Related Fatigue
Cancer-related fatigue is one of the most common and distressing symptoms experienced by patients during and after cancer treatment, and current options to manage it are limited.
- Conditions
- Cancer-related Fatigue, Breast Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- GUARANA-CRF (NCT07816263)
- Testing
- Guaraná (Paullinia cupana)
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Cortical Excitability, Brain Stimulation
Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study
Caffeine is a widely used psychostimulant drug and acts as a competitive antagonist at adenosine receptors. Its effect is on neurons and glial cells of all brain areas.
- Trial name
- NCT03720665
- Testing
- Caffeine_TMS
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Healthy
Variation in the Impact of Coffee on the Metabolic Rate
The purpose of this study is to explore variation in the impact of coffee on metabolic rate. The investigators plan to recruit healthy participants, half male and half female.
- Trial name
- NCT06432504
- Testing
- Caffeine content
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Healthy
CYP1A2 and ADORA2A Genotypes and Endurance Performance.
The aim of this randomized, double-blind, placebo-controlled experiment will be to assess the potential effect of the selected gene polymorphism (CYP1A2, ADORA2A) on performance after caffeine ingestion.
- Trial name
- NCT06547307
- Testing
- Caffeine 2 mg, Caffeine 4 mg, Caffeine 0 mg
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Exercise Performance of Fit Athletes, Exercise Performance
Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists
This study is investigating the independent and combined effects of acute dietary nitrate and caffeine supplementation on performance during a 3-minute all-out cycling test in trained male cyclists.
- Conditions
- Exercise Performance of Fit Athletes, Exercise Performance, Cycling Performance
- Trial name
- BEET (NCT07501806)
- Testing
- Dietary Nitrate, Caffeine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Obesity
Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity
Brief Summary This trial was part of a sub-project targeted to diet, thermogenesis and obesity of a larger multicentre study named "Interaction between nutritional, social-behavioral and metabolic factors for prevention of…
- Trial name
- NCT02048215
- Testing
- Caffeine, Ephedrine, Hypocaloric diet
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Istituto Auxologico Italiano
Exercise Performance, Physical Performance
Effects of Different Caffeine Forms on Aerobic and Anaerobic Exercise Performance
This study investigated the effects of different caffeine delivery forms on aerobic and anaerobic exercise performance in healthy adults.
- Trial name
- NCT07497685
- Testing
- Comparative Acute Effects of Caffeine Delivery Forms (Capsule, Chewing Gum, Mouth Rinse) on Aerobic Capacity and Wingate Anaerobic Performance Outcomes in Recreational Male Athletes: A Randomized Coun
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Apnea of Prematurity
Caffeine as Respiratory Stimulant in Preterm Infants
comparison between rate of occurance of apnea of prematurity AOP when using high and low dose caffeine
- Trial name
- NCT04144712
- Testing
- Caffeine Citrate
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT03360903
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
This is a Phase 1, Open-Label, 3-Period, Single-sequence, Drug-drug Interaction Study in Healthy Subjects to Assess the Effect of Cenicriviroc on the Pharmacokinetics (PK) of HMG-CoA Reductase Inhibitors [Rosuvastatin (ROS)…
- Trial name
- NCT02685462
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Drug Reactions
Effects of Repeated Doses of Lu AF35700 on Drug Metabolizing Enzymes
This study will help determine which types of drugs that may interact with Lu AF35700
- Trial name
- NCT03195946
- Testing
- Lu AF35700, Midazolam, Cocktail of CYP450 substrates
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Cognitive Performance, Gaming Performance
Citicoline Dose on Energy Drink Efficacy
The purpose of this study is to determine how the doses of cognitive-enhancing ingredients such as citicoline and caffeine effect the efficacy of acute energy drink consumption for improving cognitive performance (primary…
- Conditions
- Cognitive Performance, Gaming Performance, Blood Pressure, Heart Rate
- Trial name
- NCT06890962
- Testing
- Energy drink consumption
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nathaniel Jenkins
Neurologic Symptoms
Fasciculations in Healthy Adults After Consumption of Caffeine: an Ultrasound Study
Fasciculations are clinically defined as spontaneous intermittent contractions of a portion of muscles. Depending on associated symptoms they may be a sign of lower motor neuron disorder.
- Trial name
- NCT05977920
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zurich Regional Health Center
Body Composition Measurement
Acute Effects of Caffeinated and Decaffeinated Coffee on Bioelectrical Impedance Analysis
This study investigates how caffeinated coffee, decaffeinated coffee, and water affect body composition, as measured by BIA. Participants were divided into three groups, consuming their respective beverages, with measurements…
- Trial name
- NCT06754748
- Testing
- Caffeinated coffee, Decaffeinated coffee, Water
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Marmara University