Clinical trials: Calcitonin Gene-related Peptide Receptor
Migraine
A Study to Compare the Blood Levels of Two Dosage Formulations of the Study Medicine in Healthy Adults
The purpose of this study is to assess the bioequivalence of an alternative ODT formulation (ODT2) versus the approved ODT formulation of a CGRP receptor antagonist in healthy adult participants under fasting conditions.
- Trial name
- NCT07594769
- Testing
- ODT2 Test formulation, ODT Reference formulation
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteer
A Study to Compare Blood Levels of Different Dosage Formulations of the Study Medicine That Is a CGRP Receptor Antagonist in Healthy Adults
The purpose of this study is to assess the bioequivalence (medicines that may have different names or be made in different ways, but have the same effect on the body) of different formulations of a CGRP receptor antagonist in…
- Trial name
- NCT07261371
- Testing
- Test formulation (Treatment A), Reference formulation (Treatment B), Test formulation (Treatment C)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pfizer
Migraine Disorders, Brain, Healthy Adult Participants
Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine
Researchers want to find out how a substance in the body called CGRP affects balance. CGRP (calcitonin gene-related peptide) is a small protein involved in migraine. Several approved migraine medicines work by blocking it.
- Conditions
- Migraine Disorders, Brain, Healthy Adult Participants, Vestibulo-Ocular Reflex
- Trial name
- VOR-GRIP (NCT07826910)
- Testing
- Atogepant 60 mg
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konrad Peter Weber
Generalized Chronic Periodontitis, Osteoporosis
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
- Trial name
- CTROP (NCT02273128)
- Testing
- CTR Gene
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Migraine
Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)
The purpose of this study is to determine the receptor occupancy (RO) associated with telcagepant (MK-0974) administration based on displacement of [11C]MK-4232 from the CGRP receptors in the brain using PET.
- Trial name
- NCT01315847
- Testing
- telcagepant, [11C]MK-4232
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC