Clinical trials: Caloric Restriction
Obesity
Circulating Microvesicles Regulating Metabolic Homeostasis in Obesity After Caloric Restriction Programs
The main aim of the present study is to evaluate the effectiveness of two dietary protocols: Daily Caloric Restriction (DCR) and Early Time-Restricted Feeding + DCR (eTRE) on metabolic homeostasis and the influence of circulating…
- Trial name
- TREV (NCT06395246)
- Testing
- Active Comparator: Continuous calorie restriction, eTRE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Weight Loss, Inflammation
Effect of Very-low Calorie Diet and Synbiotic Supplementation in Gut Microbiota (Pronokal Method)
The present study aimed to investigate the changes produced in gut microbiota by a very-low-calorie-ketogenic diet followed by a low calorie diet, whether the use of synbiotics is able to modulate gut microbiota diversity and…
- Trial name
- Pronokal (NCT03530501)
- Testing
- Diet, Synbiotic1, Synbiotic2
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Aging
Long-term Caloric Restriction and Cellular Aging Markers
The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.
- Trial name
- CRONA (NCT01256840)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Polyphenols, Obesity
Effect of a Low-calorie Diet With a Prebiotic Supplement on Health of Overweight-obese Subjects.
The main objective of this project is to evaluate the effect of prebiotic supplementation on weight loss and other physiological and metabolic parameters related to excess weight in overweight/obese adult men and women, as well…
- Conditions
- Polyphenols, Obesity, Weight Loss
- Trial name
- POSTBIOTICS (NCT06710106)
- Testing
- Prebiotic + hypocaloric diet
- Where
- Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Aging, Cardiovascular Disease
CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and…
- Conditions
- Aging, Cardiovascular Disease, Diabetes Mellitus
- Trial name
- NCT00099151
- Testing
- Caloric Restriction (CR), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Diabetes Mellitus, PreDiabetes
Effect of Low-Calorie Diet and Lifestyle Intervention on Reversal of T2DM
An increase in body fat, even when within the normal BMI range is one of the essential drivers of T2DM in Asian Indians. In this context, the relationship between excess hepatic fat and pancreatic fat appears to be necessary.
- Conditions
- Diabetes Mellitus, PreDiabetes, Diet Habit
- Trial name
- CURE-DM (NCT05925946)
- Testing
- CURE-DM
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Insulin Resistance, NAFLD
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have…
- Trial name
- NCT02193295
- Testing
- Caloric Restriction
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy Volunteers
Monday is Fasting Day - Non-Randomized Trial on Intermittent Fasting
The aim of this pilot study is to evaluate the effects of one regular fasting day per week over a total period of 8 weeks compared to a normal-eating habits among healthy volunteers.
- Trial name
- MIFT (NCT02253056)
- Testing
- Fasting / Caloric Restriction, Healthy Diet
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Pre-diabetes, Older Adults
Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD.
The goal of this study is to evaluate the hypothesis that the addition of liraglutide, a long-acting glucagon-like peptide 1 (GLP-1) analogue, to a calorie-restricted diet will lead to greater weight loss than will a…
- Trial name
- NCT01784965
- Testing
- liraglutide
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy
Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis With a High Protein Very Low Calorie Diet
The study is designed to determine the effects of a non-pungent supplement from sweet chilli pepper on resting metabolic rate and diet-induced thermogenesis (DIT) after a period of very low calorie intake over 4 weeks.
- Trial name
- NCT01142687
- Testing
- dihydrocapsiate capsule
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Vascular System Injuries, Lipid Metabolism Disorders
Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years
Women have a natural protection that gives them greater longevity. One hypothesis most commonly used is the estrogen protection in the premenopausal period.
- Conditions
- Vascular System Injuries, Lipid Metabolism Disorders, Endothelial Disfunction
- Trial name
- NCT01668836
- Testing
- Resveratrol, Caloric restriction
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Appetite Suppression, Weight Loss
Effects of a Dietary Fibre Supplementation of a Low Calorie Diet on Appetite and Body Weight
This 18 week, randomized, double blind, placebo controlled trial will examine the effects of thick dietary fibre (PGX) supplementation of a low calorie diet (LCD) on appetite, weight loss, body composition, and compliance in…
- Trial name
- NCT01109199
- Testing
- PolyGlycopleX (PGX), Rice flour
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Canadian Center for Functional Medicine
Morbid Obesity, Steatosis
Very Low Calorie Liquid Diet for Pre op Patients
Despite the relative consensus on the benefits of pre-surgical weight loss, i.e., the reduction of comorbidities associated with surgical act, such as decreased visceral fat, liver volume, hemorrhage perioperative and surgical…
- Trial name
- NCT01748682
- Testing
- A very low calorie diet of two different consistencies
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Obesity
Human Intestinal Microbiota in Obesity and Nutritional Transition
The objectives of this study are: 1-To qualify the relationship between the gut microbiota and the host nutritional and metabolic status during dietary transition.2-To define the impact of nutritional transition on the intestinal…
- Trial name
- Micro-Obes (NCT01314690)
- Testing
- Caloric transition
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ceprodi S.A. Kot
Obesity
The Interaction Between Appetite Hormones
Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change
- Trial name
- NCT02094183
- Testing
- GLP-1, low calorie diet
- Where
- 2 sites in Denmark
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen