Clinical trials: Cancer Esophagus
Colorectal Cancer, Liver Cancer
Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Gastro-intestinal Cancer Patients
ACUPOX is a multicenter, open label, 2-cohort based phase II clinical study evaluating the interest of a standardized protocol of verum acupuncture in treatment of Oxaliplatin-induced peripheral neuropathy in patients with…
- Conditions
- Colorectal Cancer, Liver Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- ACUPOX (NCT05850130)
- Testing
- Acupuncture intervention, No acupuncture
- Where
- 15 sites in France
- Volunteers
- 182 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Esophageal Stenosis Acquired
Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Large Esophageal Carcinoma
Endoscopic submucosal dissection as the fastest growing endoscopic treatment technology in the past decade has been widely used in the treatment of early esophageal cancer and gastric cancer without local lymph node metastasis.
- Trial name
- NCT03165344
- Testing
- Hydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration), Triamcinolone Acetonide (route of administration), Prednisone (route of administration)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Esophageal Cancer, Drainage/Methods
Comparison of Drainage Methods in Minimally Invasive Esophagectomy (DEMURE）
This RCT compares three drainage approaches after minimally invasive esophagectomy (chest tube + thoracic mediastinal drainage tube, thoracic, and abdominal mediastinal drainage tube) to evaluate perioperative outcomes…
- Conditions
- Esophageal Cancer, Drainage/Methods, Postoperative Pain
- Trial name
- NCT07004634
- Testing
- Chest mediastinal tube, Abdominal mediastinal tube, Chest tube + chest mediastinal tube
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Ruijin Hospital
OESOPHAGO-GASTRIC CARCINOMA, Oesophageal Adenocarcinoma
AUGMENTED RESPONSE OF VOLATILE BIOMARKERS IN THE ASSESSMENT OF OESOPHAGOGASTRIC CANCER (AROMA2)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- OESOPHAGO-GASTRIC CARCINOMA, Oesophageal Adenocarcinoma, Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma, Oesophageal Cancer Nos
- Trial name
- AROMA2 (NCT07260734)
- Testing
- Breath Test
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer
Validation of a Nutrition Screening Tool
The objective of this study is to evaluate the sensitivity and specificity of two nutrition screening tools to identify inpatients with malnutrition or at risk of malnutrition.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer, Endometrial Cancer, Esophageal Cancer
- Trial name
- NCT01851928
- Where
- United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Lung Cancer
Phase II Evaluation of Exhaled Nitric Oxide (NO)
The goal of this clinical research study is to learn if the level of nitric oxide you breathe out may relate to the amount of breathing complications that you may experience due to radiation treatment.
- Trial name
- NCT01392144
- Testing
- Nitric oxide breath test, Questionnaires
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Esophageal Squamous Cell Carcinoma
Radiotherapy Target Volume in Locally Advanced Esophageal Squamous Cell Carcinoma in the Immunotherapy Era
This retrospective real-world cohort study will evaluate the efficacy and safety of different radiotherapy target volume extents in patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT07879898
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Oesophageal Cancer, Gastric Cancer
Google Location History Following Oesophagectomy and/or Gastrectomy
Surgery is the mainstay of treatment for patients with early-disease esophageal and gastric cancer. Open surgery for oesophageal cancer commonly involves large incisions in the chest, which is associated with a high rate of…
- Conditions
- Oesophageal Cancer, Gastric Cancer, Survivorship, Quality of Life
- Trial name
- NCT05035602
- Testing
- Physical activity assessment
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Barrett Esophagus
Photoacoustic Endoscopy of Barrett's Esophagus
Endoscopy is an important technique in medicine to diagnose internal organs. Video endoscopy has been the most common technique providing clear, real time video images of organs' surfaces.
- Trial name
- NCT02606292
- Testing
- Photoacoustic endoscopy, Endoscopic ultrasound (standard of care), Endoscopic surgery (standard of care)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine
Barretts Esophagus, Esophageal High-Grade Intraepithelial Neoplasia
Barrett&Apos;s Intervention for Dysplasia by Endoscopy
LAY SUMMARY A type of gullet cancer (oesophageal adenocarcinoma) has become the 5th commonest UK cause of cancer death. Unfortunately, by the time patients have symptoms, the cancer is often incurable.
- Conditions
- Barretts Esophagus, Esophageal High-Grade Intraepithelial Neoplasia, Esophageal Cancer Stage I
- Trial name
- BRIDE (NCT01733719)
- Testing
- ER plus RFA, ER plus APC
- Where
- 5 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- University Hospitals, Leicester
Esophageal Neoplasm, Esophageal Cancer TNM Staging Primary Tumor (T) T2
Efficacy of Intensity Modulated Radiation Therapy After Surgery in Early Stage of Esophageal Carcinoma;
The purpose of this study is to determine the efficacy of preventive intensity modulated radiation therapy after surgery in stage T2-3N0M0 disease of thoracic esophageal squamous cell carcinoma(UICC 7th edition) and to identify…
- Conditions
- Esophageal Neoplasm, Esophageal Cancer TNM Staging Primary Tumor (T) T2, Esophageal Cancer TNM Staging Primary Tumor (T) T3, Esophageal Cancer TNM Staging Regional Lymph Nodes (N) N0
- Trial name
- IMRT (NCT01745107)
- Testing
- Prophylactic postoperative radiation therapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Squamous Cell Carcinoma (ESCC)
Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Immunochemotherapy for Resectable Esophageal Cancer: A Target Trial Emulation Study
Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China, with most patients presenting with locally advanced disease.
- Trial name
- TTE-ESCC (NCT07778056)
- Testing
- Radiotherapy, Platinum-based Chemotherapy, PD-1 Inhibitor
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Esophagus Adenocarcinoma, Esophagus Squamous Cell Carcinoma
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer
Esophageal cancer, which has a low 5-year overall survival rate for all stages (<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant…
- Conditions
- Esophagus Adenocarcinoma, Esophagus Squamous Cell Carcinoma, Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT04018872
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Dallas VA Medical Center
Esophageal Cancer
Real-world Study on Comprehensive Treatment of Esophageal Cancer Based on Precision Radiotherapy
Radiotherapy is one of the main treatments for locally advanced esophageal carcinoma (EC). The accuracy of the existing imaging methods in diagnosing and predicting therapeutic efficacy is disappointing, which increases the…
- Trial name
- NCT05543057
- Testing
- 3DCRT
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zefen Xiao
Esophageal Cancer
NIF-Guided RAMIE Using ICG Versus OTE Feasibility RCT
In Canada, the incidence of esophageal cancer has been increasing over time, while surgical standards for esophageal resections have remained unchanged.
- Trial name
- RAMIE vs OTE (NCT04938973)
- Testing
- Robotic Assisted Minimally Invasive Esophagectomy (RAMIE), Open Transthoracic Esophagectomy (OTE)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Colorectal Cancer, Esophagus Cancer
A Clinical Trial Targeting CEA Chimeric Antigen Receptor T (CAR-T) for CEA Positive Advanced Malignant Solid Tumors
This is a single-arm, open, dose-increasing phase I clinical study to explore the safety, tolerability and pharmacokinetic characteristics of the drug C-13-60 cells, and preliminarily observe the efficacy of the drug in CEA…
- Conditions
- Colorectal Cancer, Esophagus Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- NCT06043466
- Testing
- CEA-targeted CAR-T cells
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Gastrointestinal Tract Malignancies
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
The purpose of this study is to evaluate the safety and preliminary clinical activity of treatment combinations with and without chemotherapy in participants with locally advanced unresectable or metastatic gastric, GEJ, and…
- Trial name
- EDGE-Gastric (NCT05329766)
- Testing
- Domvanalimab, Quemliclustat, Zimberelimab
- Where
- 43 sites in United States, Canada and 4 more
- Volunteers
- 332 people
- Sponsor
- Arcus Biosciences, Inc.
Esophageal Cancer, Lung Cancer
Minimizing Pathologic Aspiration in Patients Undergoing Esophageal and Lung Resections for Cancer
The aim of this study is to reduce pathologic aspiration and pneumonia in the perioperative period by providing an oral care and oral hygiene education to patients preoperatively.
- Trial name
- NCT04251312
- Testing
- Oral Hygiene Education and Oral Hygiene Packets
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Mississippi Medical Center
Esophageal Cancer, Chemoradiotherapy
Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC
Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced unresectable esophageal cancer, but its efficacy remains unsatisfactory.
- Trial name
- EC-CRT-008 (NCT07177794)
- Testing
- toripalimab, capecitabine
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer
Neoadjuvant Versus Adjuvant Therapy in Treating Resectable Thoracic Esophageal Cancer
This is a prospective Randomized Phase Ⅱ Trial Comparing Preoperative Chemoradiotherapy (Paclitaxel and carboplatin) Followed by Surgery to Surgery Followed by Postoperative Chemoradiotherapy (Paclitaxel and carboplatin) for…
- Trial name
- NCT01463501
- Testing
- Neoadjuvant chemoradiotherapy, Adjuvant chemoradiotherapy
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Zhejiang Cancer Hospital
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