Clinical trials: Cancer Patients and Physical Activity
Breast Cancer Metastatic
DZD1516 in Combination With Trastuzumab and Capecitabine, or in Combination With T-DM1, in Patients With Metastatic HER2 Positive Breast Cancer
DZD1516 is an oral, blood brain barrier penetrable, selective HER2 tyrosine kinase inhibitor. This study is designed to evaluate the safety and tolerability of DZD1516 in patients with metastatic HER2 positive breast cancer who…
- Trial name
- NCT04509596
- Testing
- DZD1516 mono therapy in Part A, DZD1516 in combination with trastuzumab and/or capecitabine in Part B, DZD1516 in combination with T-DM1 in Part C
- Where
- 3 sites in United States, China
- Volunteers
- 23 people
- Sponsor
- Dizal Pharmaceuticals
Colorectal Cancer
Diet and Physical Activity Intervention in CRC Survivors
Background - Colorectal cancer (CRC) incidence is increasing at an alarming rate in Hong Kong. A recent report concluded physical activity (PA) protects against colon cancer and foods low in dietary fibre, red meat and processed…
- Trial name
- NCT01708824
- Testing
- Dietary, Physical activity
- Where
- 4 sites in China
- Volunteers
- 224 people
- Sponsor
- The University of Hong Kong
Solid Tumors
Study of AUBE00 in Patients With Solid Tumors
This is a first-in-human, Phase I, open-label, multicenter, multinational study, designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and anti-tumor activity of AUBE00 in…
- Trial name
- NCT07030959
- Testing
- AUBE00, Cetuximab
- Where
- 5 sites in United States, Japan
- Volunteers
- 130 people
- Sponsor
- Chugai Pharmaceutical
Advanced Solid Cancer, Metastatic Solid Tumor
Study of SYN608 for the Treatment of Advanced or Metastatic Solid Tumors
This interventional study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of SYN608 as monotherapy in adult patients with advanced solid tumors
- Conditions
- Advanced Solid Cancer, Metastatic Solid Tumor, Ovarian Cancer, Breast Cancer
- Trial name
- NCT07088588
- Testing
- SYN608
- Where
- 2 sites in China
- Volunteers
- 105 people
- Sponsor
- Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd
Lung Cancer (Diagnosis)
The Effects of Low Intensity Endurance Exercise on Improving Mitochondrial Function, Cell Bioelectrical Impedance Phase Angle, Fatigue and Quality of Life in Lung Cancer Patients With Cancer-related Fatigue
To conduct a randomized controlled trial (RCT) targeting lung cancer patients with cancer-related fatigue to achieve the following objectives: Objective 1: To investigate whether a low-intensity endurance exercise intervention…
- Trial name
- NCT07806682
- Testing
- Low-Intensity Endurance Continuous Exercise, Low-Intensity Endurance Interval Exercise
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Medical University
Non-hodgkin's Lymphoma
A Study of GNC-038 Injection in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
To explore the safety and preliminary efficacy of GNC-038 in patients with relapsed or refractory NHL, and to determine the MTD and RP2D of GNC-038, or the MAD and DLT
- Trial name
- NCT05623982
- Testing
- GNC-038
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Melanoma (Skin)
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic Malignant Melanoma
RATIONALE: Drugs used in chemotherapy, such as 17-N-allylamino-17-demethoxygeldanamycin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00104897
- Testing
- tanespimycin
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Cancer Research UK
Bladder Cancer
Bladder Cancer and ExeRcise Training During IntraVesical ThErapy
Bladder cancer is the fifth most common cancer in Canada and has the eighth highest cancer mortality rate. The treatment for the most frequent type of bladder cancer is surgically removing the tumour followed by six weeks of…
- Trial name
- BRAVE (NCT04593862)
- Testing
- High-Intensity Interval Training
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta
Cancer, Advanced Solid Malignancies
Study is Designed to Assess the Safety and Tolerability of AZD4547 at Increasing Doses in Patients With Advanced Tumours
This study is primarily designed to assess the safety and tolerability of AZD4547 at increasing doses in patients with advanced solid malignancies and for whom no standard medication options are available.
- Trial name
- NCT00979134
- Testing
- AZD4547
- Where
- 29 sites in United States, France and 5 more
- Volunteers
- 95 people
- Sponsor
- AstraZeneca
Rectal Cancer, Low Anterior Resection Syndrome
The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer
This randomized controlled trial aims to evaluate the effects of combining Kegel exercise with a single biofeedback session on bowel function, emotional distress, and quality of life in patients who have undergone low anterior…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, LARS - Low Anterior Resection Syndrome
- Trial name
- BFT in LARS (NCT07253298)
- Testing
- Kegel Exercise with Biofeedback, Kegel Exercise Only
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Head and Neck Neoplasms
The Efficacy of Mouth Exercise in Oral Cancer Patients After Receiving Surgery
PURPOSE: The purpose of the study was to investigate the efficacy of mouth-opening training with follow-up on 1st、3rd、6th months for reducing postoperative trismus in patients with oral cancer.
- Trial name
- NCT05227807
- Testing
- mouth opening exercise, Usual care
- Volunteers
- 69 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Fatigue, Lymphoma
A Feasibility Study in Chronically Fatigued Cancer Survivors
Improved cancer survival has led to increased attention on long-term health and quality of life (QoL) among the survivors. Both the cancer diagnosis and intensive treatments increase the risk of late effects which may interfere…
- Trial name
- NCT04931407
- Testing
- A 12-week interdisciplinary complex intervention
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Metastatic Breast Cancer
Trastuzumab and Trastuzumab-MCC-DM1 Administered Intravenously and GDC-0941 Administered Orally to Patients With HER2-Positive Metastatic Breast Cancer Who Have Progressed on Previous Trastuzumab-Based Therapy
This multicenter, Phase Ib study is an open label, dose escalation, three-arm study evaluating the safety, tolerability, pharmacokinetics, and activity of oral (PO) GDC 0941 administered in combination with either intravenous…
- Trial name
- NCT00928330
- Testing
- GDC-0941, Trastuzumab, trastuzumab-MCC-DM1
- Where
- 3 sites in United States
- Volunteers
- 57 people
- Sponsor
- Genentech, Inc.
Breast Cancer Female
Exercises Using Virtual Reality on Cancer Patients
in this study, a randomized controlled trial will be conducted to evaluate the effect of adding exercises using virtual reality on achievements in patients having breast cancer and conducted surgical treatment
- Trial name
- NCT06058936
- Testing
- exercises using virtual reality technology
- Where
- Saudi Arabia
- Volunteers
- 54 people
- Sponsor
- University of Hail
Relapsed/Refractory B-cell Malignancies
A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies
This clinical trial is evaluating a drug called AC676 in participants with Relapsed/Refractory B-cell Malignancies. The main goals of the study are to: Identify the recommended dose of AC676 that can be given safely to…
- Trial name
- NCT05780034
- Testing
- AC676
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Accutar Biotechnology Inc
Epstein-Barr Virus Associated Lymphoma
Mechanistic Study of EBV mRNA Vaccine (WGc-043) in EBV-Positive Relapsed/Refractory Lymphoma
This exploratory study, based on a pharmaceutical company-initiated clinical trial, aims to investigate the therapeutic effects of the EBV mRNA vaccine (WGc-043 injection) in treating EBV-positive relapsed or refractory lymphoma.
- Trial name
- WGc-043 (NCT06788600)
- Testing
- EBV mRNA vaccine (WGc-043)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Ruijin Hospital
Multiple Myeloma (MM)
Benefits of a 6-month, Individualized, Hybrid, "Real-life" Adapted Physical Activity Program on the Quality of Life of Patients Treated for Multiple Myeloma
The goal of this clinical trial is to evaluate the effect of a long-term, individualized, hybrid adapted physical activity program on the quality of life of patients with multiple myeloma.
- Trial name
- BAPAMM (NCT07547007)
- Testing
- Adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Non Small Cell Lung Cancer (NSCLC)
A Study to Evaluate Safety and Efficacy of WSD0922-FU Combo With Osimertinib for NSCLC
This is a Phase I/II, Open Label Study of WSD0922-FU in Combination with Osimertinib for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer whose disease has progressed with third-generation EGFR-TKI with…
- Trial name
- WAYWIN103 (NCT07206498)
- Testing
- Osimertinib (Tagrisso®), WSD0922-FU
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Wayshine Biopharm, Inc.
Carcinoma, Non-small-cell Lung, Mesothelioma
Study of FAK (Defactinib) and PD-1 (Pembrolizumab) Inhibition in Advanced Solid Malignancies (FAK-PD1)
This study will explore whether defactinib (a FAK inhibitor) can be safely and tolerably combined with pembrolizumab (a PD-1 inhibitor) and will look for early indications of improved anticancer immunotherapy.
- Conditions
- Carcinoma, Non-small-cell Lung, Mesothelioma, Pancreatic Neoplasms
- Trial name
- NCT02758587
- Testing
- Defactinib, Pembrolizumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 59 people
- Sponsor
- NHS Greater Glasgow and Clyde
Endometrial Neoplasms, Uterine Cervical Neoplasms
Tissue Bank of Biological Specimens From Patients With Gynecologic Disease
The purpose of this study is to create a tissue bank of gynecologic cancers and normal tissue for the study of cancer in order to better understand the changes occurring on a molecular level (DNA, RNA, protein) that lead to the…
- Conditions
- Endometrial Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Leiomyoma
- Trial name
- NCT00299481
- Where
- 7 sites in United States
- Volunteers
- 7,000 people
- Sponsor
- U.S. Army Medical Research and Development Command
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