Clinical trials: Cancer Progression
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Hypogonadism, Atherosclerosis
Testosterone Replacement in Older Men and Atherosclerosis Progression
As men grow older, their testosterone levels decrease with age. One-third of men, 70 years of age or older, have low testosterone levels.
- Trial name
- TEAAM (NCT00287586)
- Testing
- Testosterone Gel (Androgel)
- Where
- 3 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Parkinson Disease
Cerebral Contributions to Symptom Progression in PD
Motor symptom progression in early-stage Parkinson's disease varies substantially between individual patients. This progression correlates poorly with striatal dopamine depletion, which is largely complete four years…
- Trial name
- NCT05169827
- Where
- Netherlands
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes, Plaque
DD2-Coronary Plaque Morphology and Plaque Progression
However, there is only very sparse information regarding the atherosclerotic burden and cardiovascular biomarkers in the early stages of type-2 diabetes, as the vast majority of studies have concerned diabetes populations with…
- Conditions
- Diabetes, Plaque, Atherosclerosis
- Trial name
- DD2plaque (NCT03022344)
- Testing
- Cardiac CT
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Episodic Migraine, Chronic Daily Migraine
fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease?
This is a 2 visit research study for patients with or without a diagnosis of migraine. Participants will be administered informed consent, have a medical history taken and a physical examination performed, and complete 3…
- Trial name
- NCT00868556
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Myopia, Myopia Progression
Effect of Diffusion Optics Technology (DOT) Spectacle Lenses on Choroidal Thickness
The objective of the study is to measure the effect of Diffusion Optics Technology (DOT) spectacle lenses on the choroidal thickness and choroidal vascularity index compared to control lenses.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- ASH-2 (NCT05617794)
- Testing
- Diffusion Optics Technology (DOT) Pattern Spectacle Lens, Control Spectacle Lens
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Progressive
Contact Lens and Myopia Control in Optometry School Students
The purpose of the study is to determine the effect of Natural View Multifocal lenses, a soft multifocal lens, on retardation of myopia in an optometric student population. Close up work (i.e.
- Trial name
- NCT04334369
- Testing
- Proclear Single Vision Contact Lenses manufactured by CooperVision, Proclear Multifocal Contact Lenses manufactured by CooperVision
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jeff Rabin
Metastatic Colorectal Cancer
FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation
Single-arm, multi-centre phase II study The primary objective is to evaluate the time to failure of the strategy.
- Trial name
- OPTIPRIME (NCT03584711)
- Testing
- FOLFOX + panitumumab
- Where
- 124 sites in France, Martinique
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Federation Francophone de Cancerologie Digestive
Diabetic Retinopathy (DR)
Multimodal Biomarkers in Prediction of Diabetic Retinopathy
The goal of this observational study is to enroll diabetic patients with diabetic retinopathy and those without diabetic retinopathy, follow up and observe the long-term changes in ocular structure and function of the subjects by…
- Trial name
- ZOCDR (NCT07098832)
- Where
- China
- Volunteers
- 1,538 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Clinical Deterioration
Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults
The goal of this clinical trial is to determine whether a multicomponent exercise program improves functional capacity and cognitive status in hospitalized elderly patients aged 75 and older.
- Trial name
- PREDISC (NCT06634147)
- Testing
- Exercise
- Where
- 2 sites in Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Mild Cognitive Impairment, Alzheimer's Disease
African American Alzheimer's Progression Markers - CSF and Neuro-Imaging
African Americans are twice as likely to develop Alzheimer's disease as white Americans, but few African Americans are enrolled in large Alzheimer's biomarker studies.
- Trial name
- A3PM (NCT02089555)
- Testing
- Lumbar puncture, Blood draw, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Emory University
Myopia
Controlling Myopia Progression With Soft Contact Lenses (Contact Lens Control)
This study is to investigate whether novel soft contact lens optical designs can slow myopia progression
- Trial name
- NCT01829191
- Testing
- Soft Contact Test Lens A, Soft Contact Test Lens C
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Multiple Sclerosis
Neuroretinal Biomarkers in Neurodegenerative Diseases
There is increasing evidence that examining our eyes can tell us a lot of information about our health, and systemic diseases. We want to study what eyes can reveal about serious neurodegenerative diseases like multiple…
- Trial name
- NCT02047760
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Breast Cancer
INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast Cancer
This is a phase II, randomized, multi-center, parallel design, window of opportunity trial evaluating intratumoral INT230-6 in up to 90 patients with early stage breast cancer.
- Trial name
- NCT04781725
- Testing
- INT230-6, Saline injection
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Myopia
Examination of Myopia Progression and Soft Bifocal Contact Lens Myopia Control
This project intends to provide important, previously unmet answers regarding biological associations with myopia (nearsightedness) progression in order to improve the ability to predict patients who are most likely to benefit…
- Trial name
- BLINK2 (NCT04080128)
- Testing
- Contact lenses
- Where
- 2 sites in United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Parkinson Disease, Multiple System Atrophy
Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease
To determine whether retinal abnormalities, as measured by high definition optical coherence tomography (HD-OCT) and visual electrophysiology techniques can be used as a clinical biomarker to monitor disease progression overtime…
- Conditions
- Parkinson Disease, Multiple System Atrophy, REM Sleep Behavior Disorder, Pure Autonomic Failure
- Trial name
- NCT02640339
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Metabolic Syndrome, Pregnant Women
Progression of Metabolic Syndrome Components During Pregnancy
The goal of this cohort study is to investigate the underlying risk factors to develop metabolic syndrome (MetS) during pregnancy, and the associations of MetS and its indicators with birth outcomes in southwest Ethiopia.
- Conditions
- Metabolic Syndrome, Pregnant Women, Birth Outcomes, Dietary Habits
- Trial name
- MetS_Preg (NCT05935904)
- Testing
- Exposure, Non exposure
- Where
- Ethiopia
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- University Ghent
Aggressive Periodontitis
Mechanisms and Treatment Response of Aggressive Periodontitis in Children
Although of low prevalence, aggressive periodontitis is a rapid destructive form of periodontal disease that initiates at a young age, leading to premature loss of first molars and incisors.
- Trial name
- NCT01330719
- Testing
- Diseased periodontal treatment, Conventional periodontal treatment
- Where
- 10 sites in United States
- Volunteers
- 514 people, healthy volunteers welcome
- Sponsor
- University of Florida
Kidney, Polycystic, Autosomal Dominant
High Water Intake to Slow Progression of Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a genetic disease that occurs in 1 in 500 individuals and leads to kidney failure in half of all affected. Currently, no treatments exist for PKD.
- Trial name
- NCT00784030
- Testing
- Water
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Bipolar Disorder
Bipolar Disorder Integrative Staging: Incorporating Biomarkers Into Progression Across Stages
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-speci c interventions.
- Trial name
- BOARDING-PASS (NCT07343739)
- Testing
- psychometric clinical assessment, biological acquisition, neuroimaging data
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco