Clinical trials: Cancer Uterus Cervix
Stage 0 Cervical Cancer, High-grade Squamous Intraepithelial Lesion
S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Celecoxib may be effective in preventing cervical cancer.
- Trial name
- NCT00072540
- Testing
- celecoxib, anti-cytokine therapy, antiangiogenesis therapy
- Sponsor
- SWOG Cancer Research Network
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Cervix Cancer
Investigation of Cervix Tumor Oxygenation and Microvasculature Using Magnetic Resonance Techniques
In cervix cancer tumor oxygen levels and fluid pressure in the tumor have been shown to be related to patient outcome. Analysis of the way tumors enhance after intravenous contrast injection using MRI and CT can be used to…
- Trial name
- NCT00242034
- Testing
- CT and MRI with contrast
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Cancer of Prostate, Cancer Head Neck
ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer
The aim of this study is to look at whether an Artificial Intelligence (AI) based computer program can automate two components of the radiotherapy treatment pathway to a sufficient quality standard to enable its routine clinical…
- Conditions
- Cancer of Prostate, Cancer Head Neck, Cancer Cervix
- Trial name
- NCT05653063
- Testing
- A web-based artificial intelligence (AI) auto-planning tool
- Where
- 6 sites in India, Jordan and 2 more
- Volunteers
- 1,029 people
- Sponsor
- University College, London
Corpus Uteri Carcinoma
Toxicities of Cervix and Corpus Uteri Carcinomas Treatment and Evaluation of Impact on Sexual Function
Evaluate the toxicities of cervix and corpus uteri carcinomas treatment
- Trial name
- SEXUTOX (NCT01650987)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Centre Oscar Lambret
Cervical Cancer
Comparison of Three Chemotherapy Regimens in Treating Patients With Stage IVB, Recurrent, or Persistent Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003945
- Testing
- cisplatin, topotecan hydrochloride
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 400 people
- Sponsor
- Gynecologic Oncology Group
Cancer Cervix
Carrying Out of Focus Group to Improve Cervical Screening Proposal by Vaginal Self-sampling (APACHE-4/FG).
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-4/FG (NCT03420157)
- Testing
- Focus Group
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cervical Dysplasia, Cervical Lesion
See and Treat in an Outpatient Setting in Women Above 45 Years With Cervical Dysplasia
The study will investigate if implementation of "see and treat" in the outpatient clinic can optimize the diagnosis, clinical follow-up and treatment of older women with positive cervical screening test.
- Conditions
- Cervical Dysplasia, Cervical Lesion, Cervix Disease
- Trial name
- NCT04298957
- Testing
- Cone biopsy
- Where
- 3 sites in Denmark
- Volunteers
- 109 people
- Sponsor
- University of Aarhus
Cancer of Cervix, Tumors
Ph Ib/BGJ398/Cervix and Other Solid Tumors
This study will be conducted using 3+3 design and includes, a dose escalation part to define the MTDfRP2D for the combination of BGJ398 and carboplatin/paclitaxel, and a dose expansion part to treat another 12 patients (only…
- Trial name
- NCT02312804
- Testing
- BGJ398, Carboplatin, Paclitaxel
- Sponsor
- The University of Texas Health Science Center at San Antonio
Carcinoma Cervix,Stage III
Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix
The primary aim of the trial is to study the impact of nelfinavir on 3 year disease free survival in patients with advanced carcinoma of cervix receiving standard chemoradiation (Cisplatin and Radiotherapy).
- Trial name
- NELCER (NCT03256916)
- Testing
- Nelfinavir, Cisplatin, Pelvic EBRT and Brachytherapy
- Where
- India
- Volunteers
- 348 people
- Sponsor
- Tata Memorial Hospital
Cervical Dysplasia, Vulvar Dysplasia
OCT-AF Imaging of Pre-cancers of Vulva and Cervix
The multimodal imaging technology, OCT-AFI, will be used to image sites on the cervix, the endocervical canal and vulva. The imaging probe is small enough, it can be inserted into the endocervical canal for imaging.
- Conditions
- Cervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar Cancer
- Trial name
- NCT03285841
- Testing
- OCT-AFI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Uterine Cervical Neoplasms
Irinotecan Study For Cervical Cancer
The purpose of the study is to evaluate the efficacy and safety of Irinotecan plus cisplatin as first-line chemotherapy for advanced or recurrent cervical cancer
- Trial name
- NCT00136955
- Testing
- Irinotecan
- Where
- 5 sites in Taiwan
- Volunteers
- 41 people
- Sponsor
- Pfizer
Cervical Cancers
Use Misoprostol to Optimize Prevention of Cervical Cancer
This is a double-blind randomized controlled trial of 420 non-pregnant women undergoing cancer screening by visual inspection with acetic acid (VIA) who have Type 3 transformation zone (TZ) and randomized to receive either…
- Trial name
- MISOPCx (NCT06669533)
- Testing
- Misoprostol
- Where
- Cameroon
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cancer Cervix
Image Guided Brachytherapy in Locally Advanced Cancer Cervix
This is non comparative prospective interventional study with some areas for observational research to implement based image guided adaptive cervical cancer brachytherapy ( BT ) combined with Intensity Modulated Radiotherapy …
- Trial name
- NCT04767425
- Testing
- Brachytherapy
- Volunteers
- 50 people
- Sponsor
- Fatma Ahmed Abdelfatah Rikabe
Cervical Intraepithelial Neoplasia
Immediate Treatment vs Colposcopic Follow-up for Biopsy-Proven CIN 1
This study looks at immediate treatment of a cervix with CIN 1 versus regular six-month follow-up with colposcopy and treatment if CIN 1 progresses.
- Trial name
- NCT00156026
- Testing
- loop electrosurgical excision procedure (LEEP)
- Where
- 10 sites in Brazil, Canada
- Volunteers
- 415 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion
REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)
HPV-303 is a prospective, randomized, double-blind, placebo-controlled study of VGX-3100 delivered intramuscularly (IM) followed by electroporation (EP) delivered with CELLECTRA™ 5PSP in adult women with histologically confirmed…
- Conditions
- Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion, HSIL
- Trial name
- NCT03721978
- Testing
- VGX-3100, CELLECTRA™-5PSP
- Where
- 53 sites in United States, Argentina and 8 more
- Volunteers
- 203 people
- Sponsor
- Inovio Pharmaceuticals
Cervical Cancer, Precancerous Condition
Spectroscopy in Diagnosing Dysplasia and Neoplasia in the Cervix in Women Undergoing Colposcopy
RATIONALE: New diagnostic procedures, such as spectroscopy, may be a less invasive way to check for dysplasia and neoplasia in the cervix.
- Trial name
- NCT00632190
- Testing
- fluorophotometry, colposcopic biopsy, colposcopy
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Cervical Cancer
Evaluate Efficacy of the Association Nimotuzumab(HR3) /Cisplatin-Vinorelbine on Patients With Cervical Carcinom
The objective of the present study is to estimate the overall survival of patients with cervical cancer after the administration of monoclonal antibody (mAb) Nimotuzumab (hR3) in combination with chemotherapy of first intention.
- Trial name
- CIMAHOPE (NCT03413579)
- Testing
- Nimotuzumab ( h-R3)
- Where
- 5 sites in Algeria
- Volunteers
- 37 people
- Sponsor
- El Kendi Pharmaceuticals Manufacturing Company
Prostate Cancer, Cervix Cancer
Medico-economic Evaluation of IMRT by Hi Art, RapidArc, VMAT Therapy in Prostate, Cervix and Anal Canal Cancers
The aim of the study is a medico-economic evaluation to estimate a cost differential between three modalities of Intensity-Modulated Radiation Therapy for cancers of the prostate, cervix and anal canal with pelvic lymph node…
- Conditions
- Prostate Cancer, Cervix Cancer, Anal Canal Cancers
- Trial name
- RCMI-PELVIS (NCT01325961)
- Testing
- IMRT using Rapid Arc - prostate cancer, IMRT using Rapid Arc - Anal canal cancer, IMRT using Rapid Arc - Cervix cancer
- Where
- 15 sites in France
- Volunteers
- 215 people
- Sponsor
- Institut Cancerologie de l'Ouest
Papillomavirus Infections, Early Detection of Cancer
HPV Self-sampling for Women Who do Not Attend Cervical Cancer Screening Programme
This study aims to test the effectiveness and cost-effectiveness of two different strategies of home-delivered HPV self-sampling, in comparison to the standard of care strategy, to increase adherence to cervical cancer screening.
- Conditions
- Papillomavirus Infections, Early Detection of Cancer, Cervix Cancer, Self-Examination
- Trial name
- HERSELF (NCT06371118)
- Testing
- Directly mailed self-sampling kit to collect a vaginal sample, Mailed self-sampling kit to collect a vaginal sample after opt-in prodecure, Standard of care - screening in a clinical setting
- Where
- 2 sites in Portugal
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto