Clinical trials: Cancer of Brain
Brain Cancer, Glioblastoma Multiforme
Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)
Phase I Objectives: -To determine the maximum tolerated dose (MTD) of vorinostat + erlotinib versus vorinostat + erlotinib + temozolomide in adult patients with recurrent glioblastoma multiforme (GBM) and anaplastic gliomas.
- Trial name
- NCT01110876
- Testing
- Vorinostat, Erlotinib, Temozolomide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy Volunteers, Recurrent Glioma
MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors
This first-in-human study will establish the human safety and radiation dosimetry of the system A amino acid transport substrate, (R)-3-[F-18]fluoro-2-methyl-2-(methylamino)propanoic acid ([F-18]MeFAMP), for positron emission…
- Conditions
- Healthy Volunteers, Recurrent Glioma, Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT05676489
- Testing
- [F-18]MeFAMP PET
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Brain Tumor
Brain Tumor Patient-Caregiver Congruence, MD Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT)
The goal of this study is to compare patient ratings of how severe their own symptoms may be, with their caregivers' ratings of how severe they think the patients' symptoms may be.
- Trial name
- NCT00748774
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Brain Tumor, Childhood Cancer
Biomarkers of Brain Injury in Children With Brain Tumors
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors.
- Conditions
- Brain Tumor, Childhood Cancer, Childhood Brain Tumor
- Trial name
- BiomarkCBT (NCT07381959)
- Where
- Sweden
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Diffuse Intrinsic Pontine Glioma
Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma
This phase I trial studies the side effects and best dose of temsirolimus when given together with vorinostat and with or without radiation therapy in treating younger patients with newly diagnosed or progressive diffuse…
- Trial name
- NCT02420613
- Testing
- Radiation Therapy, Temsirolimus, Vorinostat
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Solid Tumors
A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
This is an open-label, multicenter Phase 2 study evaluating Navlimetostat (BMS-986504) in participants with advanced and/or metastatic solid tumors that have MTAP deletion.
- Trial name
- NCT07492680
- Testing
- Navlimetostat, Daraxonrasib, Temozolomide
- Where
- 58 sites in United States, Belgium and 11 more
- Volunteers
- 254 people
- Sponsor
- Bristol-Myers Squibb
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Brain Tumor
Fluoro-L-Thymidine Positron Emission Tomography (FLT PET) vs. Adv. Magnetic Resonance (MR) Techniques in Recurrent Glioma
The goal of this clinical research study is to learn if using a new imaging solution, 3'-Deoxy-3'-18f-Fluorothymidine, in a positron emission tomography (PET) scan can help doctors determine if your brain lesion is from the tumor…
- Trial name
- NCT02241668
- Testing
- PET Scan, 3'-Deoxy-3'-18f-Fluorothymidine
- Sponsor
- M.D. Anderson Cancer Center
Malignant Brain Tumors
Expert Consensus and Artificial Intelligence in Medical Decision Making in Patients with Malignant Brain Tumors
Nearly 23,000 adults are diagnosed with primary central nervous system (CNS) malignancy yearly. An additional 200,000 adults are diagnosed with brain metastasis. There are significant variations in CNS tumor treatment.
- Trial name
- EC-AIM Brain (NCT06649591)
- Testing
- Survey
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Tufts Medical Center
Recurrent Meningioma, Grade I and Grade II
Ceritinib Treatment for Recurrent Meningiomas
In this study, patients with recurrent grade I and grade II meningiomas will receive a daily dose of ceritinib for abour two years. Patients will visit the clinic on average about every 2 months for assessments.
- Trial name
- CURE-M (NCT07893197)
- Testing
- Ceritinib
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Kevin Petrecca
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Brain and Central Nervous System Tumors
Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells, and may be an effective treatment for anaplastic oligodendroglioma. Combining combination chemotherapy with radiation therapy may kill more tumor cells.
- Trial name
- NCT00002840
- Testing
- lomustine, procarbazine hydrochloride, vincristine sulfate
- Where
- 40 sites in Austria, Belgium and 10 more
- Volunteers
- 350 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Pituitary Neoplasm
Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery
Tumors of the pituitary gland comprise up to 20% of all brain tumors. The central location and the small size of the pituitary gland make the management of tumors particularly challenging.
- Trial name
- NCT03678389
- Testing
- ESC
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cancer
Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as thrombopoietin and G-CSF may increase the number of immune cells found in…
- Trial name
- NCT00003597
- Testing
- recombinant human thrombopoietin, carboplatin, etoposide
- Where
- 24 sites in United States, Australia
- Volunteers
- 16 people
- Sponsor
- Children's Oncology Group
Anxiety
Immersive Virtual Reality (VR) at the Time of Clinical Evaluation to Improve Psychological Distress and Anxiety in Primary Brain Tumor (PBT) Patients
Background: Distress, anxiety, and other psychological disorders may be more common in people with primary brain tumors (PBTs). PBTs can affect their symptoms, quality of life, and their tolerance of cancer treatments.
- Trial name
- NCT04301089
- Testing
- Pico G2 4K Headset with Applied VR software, Patient Reported Questionnaires, Saliva sample collection (hormones)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer, Ovarian Cancer
Deciphering Mechanisms Underlying Cancer Immunogenicity
This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors.
- Conditions
- Head and Neck Cancer, Ovarian Cancer, Cervical Cancer, Cervical Intraepithelial Neoplasia 3
- Trial name
- DECIDE (NCT03958240)
- Testing
- Blood samples, tumor biopsy specimens and ascites samples will be collected.
- Where
- 3 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Institut Claudius Regaud
Brain Tumor
PET (FDG)-MR Imaging for the Adult Patients Presented With Brain Tumor
Background and purpose: In adult, the half of the CNS neoplasms are metastatic, and high grade astrocytomas and oligodendrogliomas are most frequent malignant tumors among the last half.
- Trial name
- NCT02071017
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Seoul National University Hospital
Brain Metastases
Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases
The purpose of the study is to determine in brain metastases and according to feasibility in liquid biopsies: Molecular alterations including in particular mutations, amplifications, Copy number gene variants and fusion…
- Trial name
- METALIQ (NCT05848050)
- Testing
- biological samples (blood test and lumbar puncture)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Brain Metastases
Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis
The goal of this diagnostic intervention clinical trial is to compare 18F-Fluciclovine uptake within brain lesions over 60 minutes compared with standard of care positive histology confirmation or confirmation MRI images.
- Trial name
- NCT06055790
- Testing
- 18F-Fluciclovine (Axumin) PET/CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Supratentorial Neoplasms, Aneurysms
Scalp Nerve Blocks for Post-Craniotomy Pain
The objective of this study is to demonstrate that scalp nerve blocks ("scalp freezing"), performed at the end of supratentorial brain surgery, will reduce post-operative pain, opioids side effects, and the time required for…
- Conditions
- Supratentorial Neoplasms, Aneurysms, Arteriovenous Malformation, Epilepsy
- Trial name
- NCT00972790
- Testing
- Bilateral Scalp Nerve Blocks
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Unity Health Toronto
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