Clinical trials: Cancer of Colon
Colon Cancer, Colo-rectal Cancer
Targeted Polymeric Nanoparticles Loaded With Cetuximab and Decorated With Somatostatin Analogue to Colon Cancer
Due to the great toxicity of chemotherapeutic drugs to both the healthy and cancerous area, the efficient targeting could be of great benefit for a patient with advanced or metastatic tumors.
- Trial name
- NCT03774680
- Testing
- Cetuximab nanoparticles, Oral approved anticancer drug
- Where
- 4 sites in Egypt, Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ahmed A. H. Abdellatif
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer, Healthy, no Evidence of Disease
Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers
This randomized phase I trial studies the side effects and best dose of linaclotide acetate in preventing colorectal cancer in healthy volunteers. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT01950403
- Testing
- linaclotide acetate, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal Cancer, Inflammatory Bowel Disease
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases
Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Disease, Atherosclerotic Cardiovascular Disease, Type2 Diabetes Mellitus
- Trial name
- NCT04924686
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Breast Cancer, Prostate Cancer
Redes III Patient Navigator Qol Study
This proposed 5-year Redes En Acción research study involves a mixed-methods approach that occurs in two phases across two distinct and diverse HL communities.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02275754
- Testing
- PN+LCNC, PN Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Colorectal Cancer
The Safety and Efficacy of Methylene Blue MMX® Modified Release Tablets Administered to Subjects Undergoing Screening or Surveillance Colonoscopy
Evaluation of the histologically proven adenoma and carcinoma detection rate in patients undergoing a full colonoscopy with and without mucosal contrast enhancement, obtained with 200 mg of Methylene Blue MMX® tablets.
- Trial name
- NCT01694966
- Testing
- Methylene Blue MMX®
- Where
- 19 sites in United States, Belgium and 6 more
- Volunteers
- 1,249 people, healthy volunteers welcome
- Sponsor
- Cosmo Technologies Ltd
Stage IV Melanoma, Advanced Lung Cancer
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.
- Conditions
- Stage IV Melanoma, Advanced Lung Cancer, Stage IV Non-Small Cell Lung Cancer, Unresectable Non-Small Cell Lung Carcinoma
- Trial name
- UPLIFT (NCT04670445)
- Testing
- Educational Video and QPL List, Usual Care
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer (Diagnosis)
Secondary Care Colorectal Cancer Pathway Review
Bowel cancer (colorectal cancer) is the 4th most common cancer in Scotland. Approximately 4,000 cases are diagnosed annually. Cancer-related deaths in Scotland are higher than other UK nations.
- Trial name
- NCT07430527
- Testing
- Faecal Immunohistochemical test
- Where
- 2 sites in United Kingdom
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Colorectal Neoplasms, Colonic Polyps
Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study
We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Colorectal Cancer
- Trial name
- NBI (NCT01310699)
- Testing
- Olympus Colonoscope CFHQ190AL
- Where
- 3 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Colorectal Cancer
Feasibility, Reliability, and Satisfaction of CEA Using Home Based (Automated) Capillary Blood Sampling
The goal of this study is to determine the feasibility of CEA assessments at home using (automated) capillary sampling in patients in the follow-up after treatment for colorectal cancer.
- Trial name
- CASA-I (NCT05646030)
- Testing
- TAP-II, Lancet capillary sampling, Venipuncture
- Where
- Netherlands
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Colorectal Cancer
A Multi Center Study Comparing the Efficacy of CAD EYE and the Standard of Care (White Light )
This study is to assess the sensitivity and added benefits of CADEYE compared to standard care (white-light) in detecting colon polyps in patients undergoing colonoscopy.
- Trial name
- NCT05523271
- Testing
- CAD EYE (Computer Aided Diagnosis ----?
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Colon Cancer, Polyp
Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.
The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy.
- Conditions
- Colon Cancer, Polyp, Adenoma
- Trial name
- NCT00245492
- Testing
- Chromocolonoscopy
- Where
- 3 sites in United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer, Screening Compliance
WhatsApp Reminder on FIT Compliance
It is estimated that there are about 1.4 million patients with colorectal cancer (CRC) worldwide, with a rising trend in CRC incidence in many Asian Pacific countries.
- Conditions
- Colorectal Cancer, Screening Compliance, Fecal Immunochemical Test
- Trial name
- NCT03209765
- Testing
- WhatsApp reminder
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer
PillCam Colon Capsule and CT-colonography in the Evaluation of Patients With Incomplete Conventional Colonoscopy
Colorectal cancer (CRC) is the second most common cause of cancer-related death in the Western world, with 500000 deaths per year worldwide. Colonoscopy is accepted as a primary CRC screening tool in many countries.
- Trial name
- NCT01525940
- Testing
- PillCam Colon Capsule Endoscopy (Given® Diagnostic System)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Adenomatous Polyp, New Imaging Techniques in Colonoscopy
Narrow Band Imaging Colon Polyp Study
In this study the investigators hypothesize that High Definition White Light colonoscopy and narrow band imaging (NBI) will detect a higher number of adenomas compared to standard definition white light colonoscopy.
- Trial name
- NCT00614770
- Testing
- standard of care colonoscopy, colonoscopy
- Where
- 2 sites in United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Kansas City Veteran Affairs Medical Center
Colon Cancer Prevention
Effect of Exercise on Biomarkers of Colon Cancer Risk
There is strong observational epidemiologic evidence that physical activity is inversely associated with risk of colon cancer occurrence in both men and women.
- Trial name
- APPEAL (NCT00668161)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Chemotherapy-induced Peripheral Neuropathy
Effects of Massage Therapy on Peripheral Neuropathy and Quality of Life
The aim of this randomized controlled experimental study was to determine the effect of massage applied to colorectal cancer patients receiving chemotherapy on peripheral neuropathy and quality of life.
- Trial name
- NCT05433246
- Testing
- Massage therapy group
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fatma Arikan
Fecal Immunochemical Test, Colorectal Cancer Screening
Implementation Intention Planning Guide for FIT Colon Cancer Screening
Fecal immunochemical tests (FIT) are a primary method of screening for colorectal cancer (CRC). Implementation intention planning involves encouraging completion or eliminating barriers for the participant to make a plan to…
- Trial name
- NCT07183046
- Testing
- Implementation Intention Guide
- Where
- 5 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Colorectal Cancer, Colon Cancer
Pilot Study of Colon Cancer Screening Tests
Colon cancer is the second leading cause of cancer death in North America. These deaths are preventable with proper screening. Fecal occult blood testing, virtual colonoscopy, and standard (optical) colonoscopy are all options…
- Conditions
- Colorectal Cancer, Colon Cancer, Adenomatous Polyps
- Trial name
- NCT00865527
- Testing
- Fecal occult blood test, Virtual colonoscopy, Optical colonoscopy
- Where
- Canada
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation