Clinical trials: Cancer of the Esophagus
Cancer
Dose Escalation Study of I-131-CLR1404 in Subjects With Cancer That Does Not Respond to Treatment or Has Returned
The purpose of this study is to determine the recommended dose of I-131-CLR1404, a radiolabeled therapy compound, for treating subjects with cancer that does not respond to treatment or has returned.
- Trial name
- NCT01495663
- Testing
- I-131-CLR1404
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Cellectar Biosciences, Inc.
Esophageal Cancer, Esophagus Cancer
Sequentially Administered CPT-11 and Mitomycin C in Patients With Advanced Esophageal and Stomach Cancer
To determine the most efficacious of two combination regimens of sequential CPT-11 and MMC in patients with advanced and previously untreated esophageal and GE junction adenocarcinomas.
- Conditions
- Esophageal Cancer, Esophagus Cancer, Cancer of Stomach, Stomach Cancer
- Trial name
- NCT00201747
- Testing
- CPT-11, Mitomycin C
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Advanced Cancers
Randomized Trial of Glutamine in Patients With Mucositis or Esophagitis
The goal of this clinical research study is to learn if glutamine can help control and prevent sores, blisters, or inflammation in your mouth or esophagus due to your current treatment.
- Trial name
- NCT01952847
- Testing
- Glutamine, Questionnaires
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer, Esophagus Cancer
Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis
This study constitutes a case-control investigation employing a retrospective approach. Plasma samples from individuals with esophageal cancer, benign esophageal diseases, gastric cancer, benign gastric diseases, and a healthy…
- Trial name
- NCT06278064
- Testing
- Gastric Cancer, Esophagus Cancer
- Where
- 3 sites in China
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Chemotherapy, Radiation Therapy
Immunotherapy Plus Chemotherapy vs. Chemoradiotherapy for Thoracic Squamous Esophageal Carcinoma
The investigators conducted a phase II, prospective, two-arm clinical study to explore the efficacy of Camrelizumab combined with chemotherapy versus chemoradiotherapy for conversion therapy of potentially resectable advanced…
- Trial name
- NCT05821452
- Testing
- Camrelizumab, Paclitaxel, Cisplatin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Cancer
Phase I/II Study of Taxotere,CDDP and 5-FU(TPF) in Pre-treated Pts With Metastatic Esophageal Cancer.
A phase I/II study is conducted to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and efficacy of a combination chemotherapy using docetaxel, cisplatin and 5-fluorouracil (TPF) in Pre-treated patients…
- Trial name
- NCT00209716
- Testing
- Taxotere, 5-Fluorouracil, Briplatin
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Hokkaido Gastrointestinal Cancer Study Group
Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms
Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
This is an Open, Single Arm, Exploratory and Phase II Clinical Trial of Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma (ESCC) Patients as Postoperative Adjuvant Therapy.
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Esophageal Diseases, Gastrointestinal Neoplasms
- Trial name
- ALTER-E005 (NCT05252078)
- Testing
- Anlotinib hydrochloride, TQB2450
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Esophageal Carcinoma
Cadonilimab Combined With Anlotinib Followed by Radiotherapy in Recurrent or Metastatic Esophageal Squamous Cell Carcinoma (CAR-RMEC)
GLOBOCAN 2020 reported that the global incidence of esophageal cancer climbed to 604,100, accounting for 3.1% of all tumor sites and ranking 7th out of 36 cancers.
- Trial name
- CAR-RMEC (NCT06681285)
- Testing
- Cadonilimab ;Anlotinib
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Hebei Medical University Fourth Hospital
Esophageal Carcinoma Salivary Gland Type, Radiotherapy
The Study on the Mechanism of Radiotherapy-elicited Immune Response
Radiotherapy plays an important role in multidisciplinary treatment of esophageal cancer. Data from many laboratories indicate that local radiation produces systemic, immune-mediated anti¬tumour and, potentially, antimetastatic…
- Trial name
- NCT06393140
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Esophageal Neoplasms, Esophageal Diseases
Combination of Radiation Therapy and Peptide Specific CTL Therapy in Treating Patients With Esophageal Cancer
Immunotherapy is now considered to be one of promising approaches for treating cancer. Radiation therapy has been to be a cornerstone treatment for unresectable advanced esophageal cancer.
- Conditions
- Esophageal Neoplasms, Esophageal Diseases, Digestive System Diseases
- Trial name
- NCT03011255
- Testing
- peptide specific CTL
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shixiu Wu
Ovarian Cancer, Non Small Cell Lung Cancer
A Study in Ovarian, Non-Small Cell Lung, Prostate, Colorectal, Gastroesophageal Cancers, and Squamous Cell Carcinoma of the Head and Neck
The purpose of the study is to estimate the rate of response for patients with ovarian, non-small cell lung, prostate, colorectal, gastroesophageal, and head and neck cancers who are administered LY2523355.
- Conditions
- Ovarian Cancer, Non Small Cell Lung Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT01059643
- Testing
- LY2523355, pegfilgrastim
- Where
- 18 sites in United States
- Volunteers
- 103 people
- Sponsor
- Eli Lilly and Company
Esophageal Carcinoma
Nimotuzumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age
The research subjects of this project are mainly aimed at patients with locally advanced esophageal cancer who cannot be treated surgically, in nimotuzumab 3 months after the end of concurrent chemoradiotherapy, RECIST is pressed…
- Trial name
- NCT06048913
- Testing
- Nimotuzumab, S-1, Concurrent radiation therapy
- Where
- China
- Volunteers
- 56 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastric Cancer, Esophageal Cancer
Safety and Efficacy of Personalized Neoantigen Vaccine in Advanced Gastric Cancer, Esophageal Cancer and Liver Cancer
This trial is an investigator-initiated, single-center, open-label, single-arm exploratory study of mRNA neoantigen tumor vaccine in the treatment of advanced gastric cancer, esophageal cancer, and liver cancer, including two…
- Conditions
- Gastric Cancer, Esophageal Cancer, Liver Cancer
- Trial name
- NCT05192460
- Testing
- neoantigen tumor vaccine with or without PD-1/L1
- Where
- China
- Volunteers
- 30 people
- Sponsor
- jianming xu
Breast Cancer, Colorectal Cancer
A Study to Evaluate the Safety and Dosimetry of 68Ga-labelled OncoFAP Derivatives in Solid Tumors
The primary objectives of this trial are to evaluate the safety and dosimetry of [68Ga]Ga-OncoFAP for detection/imaging of solid tumors.
- Conditions
- Breast Cancer, Colorectal Cancer, Oesophageal Cancer, Pancreas Adenocarcinoma
- Trial name
- FAPrimo (NCT05784597)
- Testing
- [68Ga]Ga-OncoFAP administration
- Where
- 5 sites in Italy
- Volunteers
- 18 people
- Sponsor
- Philogen S.p.A.
Colorectal Carcinoma, Rectal Prolapse
Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic Surgery
Robotic assisted surgery has been performed for more than two decades with good success and safety profile. However, there was only one dominating robotic surgical system available in the past which led to high cost for robotic…
- Conditions
- Colorectal Carcinoma, Rectal Prolapse, Prostate Cancer (Adenocarcinoma), Bladder Cancer
- Trial name
- NCT06926374
- Testing
- Robotic surgery using the Sentire Surgical System
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Blood Pressure, Hypertension
Onco-primary Care Networking to Support TEAM-based Care
The proposed ONE TEAM Study is an 18-month, cluster randomized controlled trial. This study will use a sequential multiple assignment randomized trial (SMART) design with a second randomization for the intervention group using a…
- Conditions
- Blood Pressure, Hypertension, Cancer, Cancer, Breast
- Trial name
- ONE TEAM (NCT04258813)
- Testing
- iGuide Intervention (Self-guided), iGuide 2 Intervention (Tailored/Targeted), Control
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- Duke University
Esophageal Squamous Cell Carcinoma, Esophageal Squamous Dysplasia
Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma
In the current protocol, we propose a study to evaluate a novel, combined esophageal sponge-methylation biomarker strategy for the early detection of esophageal squamous cell carcinoma (ESCC) as well as its precursor, esophageal…
- Trial name
- NCT05028725
- Testing
- EsophaCap Sponge, Chromoendoscopy, EsoCAN assay
- Where
- 2 sites in Tanzania
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gastrointestinal Neoplasms, Pancreatic Neoplasms
Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery
Major visceral oncologic surgery is associated with high postoperative morbidity, prolonged hospitalization, delayed recovery, and reduced quality of life.
- Conditions
- Gastrointestinal Neoplasms, Pancreatic Neoplasms, Liver Neoplasm, Oesophageal Cancer
- Trial name
- P2R-OncoVis (NCT07658313)
- Testing
- Digitally Supported Multimodal Prehabilitation
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Ludwig Boltzmann Institute for Digital Health and Prevention
Esophageal Cancer, Gastric Cancer
Avastin and Taxotere for Esophagogastric Cancer
The purpose of this study is to determine what effects (good and bad) bevacizumab (Avastin) and docetaxel (Taxotere), used in combination, have on metastatic gastric and esophageal cancer.
- Trial name
- NCT00137813
- Testing
- Docetaxel, Bevacizumab
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Dana-Farber Cancer Institute
Barrett's Esophagus, Esophageal Squamous Dysplasia
Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium
Assess Cryoablation (CryoBalloon Ablation cryotherapy) for treatment of Dysplastic Barrett's Esophagus, Esophageal Squamous Dysplasia and early Esophageal Cancer.
- Conditions
- Barrett's Esophagus, Esophageal Squamous Dysplasia, Esophageal Cancer
- Trial name
- ColdPlay2 (NCT02534233)
- Testing
- CryoBalloon
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
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