Clinical trials: Cancer of the Head and Neck
the Records of Esophageal Cancer
RESECTED LYMPH NODES AND SURVIVAL OF PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA: AN OBSERVATIONAL STUDY
To clarify the effect of the number of lymph node dissection and the number of stations on survival
- Trial name
- NCT05570487
- Testing
- Since the data were collected retrospectively, there were no interventions
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Yongtao Han
Squamous Cell Carcinoma Mouth
Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma
To evaluate the diagnostic accuracy of preoperative MRI in the determination of the primary tumor depth of invasion (DOI) as a predictor factor in neck lymph nodes management in T1T2N0 oral cavity squamous cell carcinomas as…
- Trial name
- NCT07127614
- Testing
- MRI, Histo-Pathological examination of the resected tumor tissues
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Al-Azhar University
Head and Neck Squamous Cell Carcinoma
Transoral Robotic Surgery and Tailored Radiotherapy in Unknown Primary and Small Squamous Cell Head and Neck Cancer
The purpose of this study is to evaluate the use of Transoral Robotic Surgery (TORS) to identify small oropharyngeal carcinomas.
- Trial name
- FIND (NCT03281499)
- Testing
- da Vinci Surgical System Model IS4000
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Head and Neck Neoplasms, Mucositis Oral
Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy
This study aims to propose an alternative and auxiliary methodology for the prevention and treatment of Oral Mucositis (OM) in patients undergoing radiotherapy or radio and chemotherapy for head and neck neoplasms through the use…
- Conditions
- Head and Neck Neoplasms, Mucositis Oral, Radiotherapy; Complications
- Trial name
- NCT05308732
- Testing
- Copaiba
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Head and Neck Cancer, Oral Complications
Sargramostim in Decreasing Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer
RATIONALE: Sargramostim may lessen symptoms of mucositis in patients receiving radiation therapy for head and neck cancer. It is not yet known if sargramostim is more effective than no treatment in reducing mucositis caused by…
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00008398
- Testing
- sargramostim, quality-of-life assessment, radiation therapy
- Where
- 236 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Head and Neck Cancer
Chemotherapy Plus Gefitinib Followed by Chemotherapy, Radiation Therapy, and Gefitinib For Head and Neck Cancer
Although gefitinib has been combined successfully with various chemotherapeutic regimens with minimal increase in overall toxicity, experience with concurrent radiation therapy is limited.
- Trial name
- NCT00193284
- Testing
- Gefitinib, Docetaxel, Carboplatin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- SCRI Development Innovations, LLC
Head and Neck Cancer
On-treatment Adaptation of Head and Neck Cancer Dosimetry Plans Using Novel Cone-beam CT and AI-driven Software
This is a feasibility study investigating the use of a high-performance HyperSight cone beam CT (CBCT) and adaptive planning software for both online and offline radiotherapy treatment planning for head and neck cancer.
- Trial name
- NCT05666193
- Testing
- CBCT Imaging
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Varian, a Siemens Healthineers Company
Head and Neck Cancer
Panitumumab IRDye800 Optical Imaging Study
Phase I trial to evaluate the safety of escalating dose levels of conjugated panitumumab-IRDye800 in subjects with head and neck squamous cell carcinoma (HNSCC) that undergo surgery with curative intent.
- Trial name
- NCT02415881
- Testing
- Panitumumab IRDye 800, da Vinci Firefly, IMAGE1 + ICG Hopkins telescope and/or VITOM
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Eben Rosenthal
Oral Mucositis
Melatonin Oral Gel for Oral Mucositis in Patients With Head and Neck Cancer Undergoing Chemoradiation
The main purpose of this study is to assess the efficacy of melatonin oral gel compared to placebo in the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing concurrent chemoradiation.
- Trial name
- MUCOMEL (NCT02630004)
- Testing
- Melatonin oral gel 3%
- Where
- 11 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Spherium Biomed
Mouth Neoplasms, Oropharyngeal Neoplasms
F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients
This is an imaging protocol only, not a therapeutic study. The primary goal of the proposed study is to examine the utility of a new imaging study, Positron Emission Tomography with F-18 Fluorothymidine (FLT PET), in the early…
- Conditions
- Mouth Neoplasms, Oropharyngeal Neoplasms, Laryngeal Neoplasms, Head and Neck Neoplasms
- Trial name
- NCT00721799
- Testing
- 18F-Fluorothymidine PET scan
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Iowa
Smoking Cessation
Smoking Cessation Treatment for Head and Neck Cancer Patients
This is a pilot research study examining the use of varenicline (Chantix) and the nicotine patch. The study is designed to find out whether one of these medications is more effective for smoking cessation with head and neck…
- Trial name
- NCT00931021
- Testing
- Varenicline (Chantix), Nicotine Patch
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Head and Neck Cancer
Reduced Radiotherapy With Pac/Cis vs Standard Radiotherapy With 5-FU/Cis in Locally Advanced Head and Neck Cancer
Reduced RT with Pac/Cis vs. standard RCT with 5-FU/Cis
- Trial name
- Paccis-RCT (NCT01126216)
- Testing
- Paclitaxel/Cisplatin, Reduced RT, 5-FU/Cisplatin
- Where
- 13 sites in Germany
- Volunteers
- 221 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary
S0420, Sorafenib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Sorafenib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. It may also stop the growth of tumor cells by stopping blood flow to the tumor.
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT00096512
- Testing
- sorafenib tosylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer
Feasibility of Imaging in the Treatment of Patients With Advanced Head and Neck Cancer
The purpose of this study is to obtain preliminary information on the potential of 99m Tc-EC-DG SPECT imaging to distinguish cancer from non cancer.
- Trial name
- NCT01359267
- Testing
- 99mTc-EC-DG
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Chicago
Head and Neck Squamous Cell Carcinoma
A Phase I Comparative Study of Pharmacokinetics, Safety, and Efficacy of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma
The primary objective of this clinical study is to compare the pharmacokinetic parameters of drugs RPH-002 and Erbitux® after a single intravenous administration, as well as to evaluate the safety of drug RPH-002 in comparison…
- Trial name
- NCT07435311
- Testing
- RPH-002, Erbitux®, cisplatin
- Where
- 18 sites in Russia
- Volunteers
- 118 people
- Sponsor
- R-Pharm
Head and Neck Cancer
Impact of the Oral Microbiota on Relapse in HNSCC Patients
to characterise the impact of microbiota in radiotherapy efficacy
- Trial name
- MICR-ORL (NCT06807034)
- Testing
- buccal swabs
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Sainte Catherine
Adenocarcinoma of the Esophagus or Esophagogastric Junction
Palliative Short-course Hypofractionated Radiotherapy Followed by Chemotherapy in Adenocarcinoma of the Esophagus or Esophagogastric Junction Trial - a Phase II Clinical Trial Protocol.
In this trial, patients with histologically proven adenocarcinoma of the esophagus or esophagogastric junction noneligible for surgery or chemoradiation with curative intent will be included.
- Trial name
- PALAESTRA (NCT02241499)
- Testing
- Radiation therapy, Oxaliplatin and fluorouracil.
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Advanced Solid Tumor
Phase I/IIa Study of BR790 in Combination With Tislelizumab in Adult Subjects With Advanced Solid Tumors
This study is a Phase I/IIa, multi-center, open-label study of BR790 in combination with Tislelizumab with a dose escalation part followed by a dose expansion part in adult subjects with advanced solid tumors.
- Trial name
- NCT05505877
- Testing
- BR790+Tislelizumab
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Gopherwood Biotech Co., Ltd.
Head and Neck Cancer, Cancer of the Head and Neck
Fluorescence Imaging in Head and Neck Cancer
Fluorescent technology continues to advance in the detection of sentinel lymph nodes (SLNs). Currently, this requires switching from near-infrared light to white light to be able to identify the fluorescent tissue contrasting…
- Trial name
- NCT03297957
- Testing
- Hands-free goggle system
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Head and Neck Cancer, Head and Neck (HNSCC)
APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma
This Phase 3, multicenter, randomized, open-label study evaluates APG-157 in adults with newly diagnosed locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
- Conditions
- Head and Neck Cancer, Head and Neck (HNSCC), Oropharyngeal, Oral Cavity
- Trial name
- NCT07667296
- Testing
- APG-157, Surgery, Radiation/Chemotherapy
- Volunteers
- 826 people
- Sponsor
- Aveta Biomics, Inc.
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