Clinical trials: Cancer-Associated Pain
Opioid-Induced Constipation
Study Evaluating Safety & Efficacy of Subcutaneous Methylnaltrexone on Opioid-Induced Constipation in Cancer Subjects
This purpose of this study is to evaluate the safety and effectiveness of a subcutaneous (injection beneath the skin) form of methylnaltrexone in subjects who have cancer-related pain and constipation from taking opioids.
- Trial name
- NCT00858754
- Testing
- methylnaltrexone
- Where
- 8 sites in United States, Canada and 2 more
- Sponsor
- Bausch Health Americas, Inc.
Anxiety Disorder, Chronic Myeloproliferative Disorders
Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation
RATIONALE: Music therapy may be effective in relieving pain and emotional distress in patients who are undergoing cancer therapy.
- Conditions
- Anxiety Disorder, Chronic Myeloproliferative Disorders, Depression, Lymphoma
- Trial name
- NCT00014482
- Testing
- pain therapy, psychosocial assessment and care
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Therapeutic Touch, Cancer
Reiki for Cancer: Pain, Anxiety, and Stress
The goal of this clinical trial is to investigate the effects of Reiki, Sham Reiki, and Progressive Relaxation Exercise on the levels of pain, anxiety, and stress in cancer patients.
- Trial name
- NCT06296680
- Testing
- Reiki, Progressive Relaxation Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Ege University
Pain, Burning, Pain, Crushing
A Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Cancer-related Pain
The purpose of this study is to compare the safety and effectiveness of JNJ-42160443 with placebo in the treatment of chronic, moderate to severe cancer-related pain in terminally ill patients with a diagnosis of active cancer.
- Conditions
- Pain, Burning, Pain, Crushing, Pain, Migratory, Pain, Radiating
- Trial name
- NCT00929188
- Testing
- JNJ-42160443
- Where
- 40 sites in United States, France and 3 more
- Volunteers
- 100 people
- Sponsor
- Janssen Research & Development, LLC
Cancer, Pain
Acetaminophen for Cancer Pain
Many patients with cancer pain have pain not fully controlled on opioids (eg. morphine). The addition of acetaminophen (Tylenol) to opioids in a small study in cancer patients demonstrated better pain control without an increase…
- Trial name
- NCT00152854
- Testing
- Acetaminophen
- Where
- 2 sites in Australia, Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Chronic Pain
Intrathecal Therapy for Chronic Non-Cancer Pain: An Analysis of Its Efficacy
Our hypothesis is that patients with intrathecal delivery systems for chronic non-cancer pain will report no improvement treatment efficacy when compared to patients with chronic pain managed with oral or systemic opioid…
- Trial name
- NCT01564069
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS)
Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms
Both Tart Cherry and Omega 3 FAs have better side effect profiles compared to other commonly used medications for AIMSS, such as nonsteroidal anti-inflammatories, steroids, and serotonin norepinephrine reuptake inhibitors.
- Conditions
- Breast Cancer, Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS), Joint Pain
- Trial name
- NCT06123286
- Testing
- Tart Cherry, Omega 3 FA (Fish Oil)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Philip Chang
Pancreatic Cancer Non-resectable, Tumor Pancreas
Upfront EUS CGN/CPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer
Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment.
- Conditions
- Pancreatic Cancer Non-resectable, Tumor Pancreas, Pain Cancer
- Trial name
- NCT06160323
- Testing
- EUS-guided coeliac ganglion neurolysis / celiac plexus neurolysis
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- Chinese University of Hong Kong
Pain
Fentanyl for Breakthrough Pain in the Emergency Department
The goal of this clinical research study is to learn if fentanyl nasal spray can help decrease pain related to cancer when used with other drugs for pain.
- Trial name
- NCT01812759
- Testing
- Fentanyl Nasal Spray, Hydromorphone PCA
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Myeloproliferative Disorders, Leukemia
Treatment for Chronic Pain in Patients With Advanced Cancer
RATIONALE: Different drug formulations and combinations of drugs may help patients with chronic pain live more comfortably. It is not yet known which regimen is most effective for chronic pain.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003687
- Testing
- dextromethorphan hydrobromide, morphine sulfate
- Where
- 4 sites in Canada
- Volunteers
- 87 people
- Sponsor
- NCIC Clinical Trials Group
Bone Metastases of a Malignant Tumor, Cancer Pain
Single Fraction and Multifraction Arc-Based Radiotherapy for Painful Bone Metastases
This prospective randomised pilot feasibility study will compare single-fraction radiotherapy (8 Gy × 1) with multifraction radiotherapy (20 Gy in 5 fractions) for the palliation of painful bone metastases.
- Trial name
- SMART (NCT07772206)
- Testing
- Single-Fraction Radiotherapy (8Gy x 1#), Multifraction Radiotherapy (20 Gy in 5 #)
- Where
- Oman
- Volunteers
- 70 people
- Sponsor
- Oman Ministry of Health
Cancer Rectum, Cancer Vulva
Interventions for the Management of Perineal Cancer Pain
Pain associated with neoplasms may be of somatic, visceral, or neuropathic origin.Visceral pain or pain that is mediated by the sympathetic fibers in the perineal area associated with malignancy in the pelvis may be effectively…
- Conditions
- Cancer Rectum, Cancer Vulva, Cancer Vagina
- Trial name
- NCT06392399
- Testing
- cooled radiofrequency ,, conventional radiofrequency, neurolysis of ganglion
- Volunteers
- 60 people
- Sponsor
- Assiut University
Nausea Post Chemotherapy, Vomiting
Pharmacokinetic and Pharmacodynamic Evaluation of Formulations of Δ9-THC
Study based on the pharmacokinetic, pharmacodynamic, safety and stability evaluation of 3 standardized formulations of THC, to be used in healthy volunteers and post-chemotherapy patients as an adjuvant in the symptomatic…
- Conditions
- Nausea Post Chemotherapy, Vomiting, Cancer Pain, Cancer Related Pain
- Trial name
- NCT05272865
- Testing
- Pharmacokinetic and pharmacodynamic profile of THC oral formulations with Dronabinol as comparator
- Where
- Colombia
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- LaSanta S A S
Cancer Pain, Neoplasm-Related Pain
Treatment of Cancer Pain Using an Implantable Intrathecal Pump
This study evaluates the effectiveness and safety of an implantable intrathecal pump for the treatment of cancer-related pain compared with standard subcutaneous analgesic infusion.
- Trial name
- NCT07427888
- Testing
- Subcutaneous Analgesic Pump, Implantable Intrathecal Pump
- Where
- Slovenia
- Volunteers
- 8 people
- Sponsor
- Institute of Oncology Ljubljana
Cancer
An Internet-based Program to Help Cancer Survivors Manage Pain
To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the…
- Trial name
- IMPACTS (NCT04462302)
- Testing
- Internet-based pain coping skills program
- Where
- 150 sites in United States, Guam
- Volunteers
- 456 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer Survivors
taVNS for Breast Cancer Pain and Symptom Management
1. To evaluate the feasibility and acceptability of a home-based taVNS intervention and follow-up for pain and symptom management in breast cancer survivors. 2.
- Trial name
- NCT07500012
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Florida State University
Chronic Nociceptive Pain, Neuropathic Pain
A Pilot Study of Ultra Rapid Opioid Rotation and Titration of Oxymorphone
This project will explore the safety and feasibility of performing a successful intravenous patient controlled analgesia (IV PCA) Oxymorphone titration and conversion to oral ER Oxymorphone (extended release or OPANA ER) in the…
- Conditions
- Chronic Nociceptive Pain, Neuropathic Pain, Non-cancer Pain
- Trial name
- NCT00945919
- Testing
- Oxymorphone ER
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cancer, Pain
Determine the Safety and Efficacy of Oxy/Nal Tablets Compared to Oxy PR in Subjects With Cancer Pain
To Determine the Safety and Efficacy of Oxycodone / Naloxone Prolonged Release Tablets compared to Oxycodone PR in Subjects with Moderate to Severe, Chronic Cancer Pain
- Trial name
- NCT01885182
- Testing
- Oxycodone/Naloxone, Oxycodone
- Where
- 28 sites in China
- Volunteers
- 232 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Chronic Pain
Effect and Safety of Listening to Music for Chronic Pain Relief
Chronic pain is a multidimensional pathological condition that reduces patients' quality of life and interferes with their daily family and work activities. Opioids are the most powerful analgesics in the treatment of pain.
- Trial name
- NCT05726266
- Testing
- Music, Audiobook
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Víctor Fernández-Dueñas
Cancer, Pain
A Study to Compare the Titration Efficacy and Safety of Control-released Oxycodone and Immediate-released Oxycodone in Patients With Moderate to Severe Cancer Pain
This study is to evaluate the efficacy and safety of a titration method by selects 10 mg control-released (CR) oxycodone tablet as background drug in combined with immediate-released (IR) oxycodone, compared to conventional…
- Trial name
- NCT03176199
- Testing
- Oxycodone
- Where
- 4 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- Taiwan Mundipharma Pharmaceuticals Ltd.