Clinical trials: Cancer-Associated Pain
Breakthrough Cancer Pain
A Dose Titration Study of Fentanyl Buccal Soluble Film for Breakthrough Cancer Pain in Taiwan
Primary Objective: To determine the feasible dose range of Painkyl® required for Taiwanese population. Secondary Objectives: To evaluate the efficacy of Painkyl® by calculating squared mean of pain intensity difference at 30…
- Trial name
- NCT03669263
- Testing
- Fentanyl buccal soluble film (FBSF)
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Cancer, Chronic Pain
Tapentadol in Chronic Malignant Tumour Related Pain
The purpose of this trial is the characterization of the long term safety profile and long-term dose requirements of tapentadol PR (prolonged release) in patients with malignant tumor-related pain.
- Conditions
- Cancer, Chronic Pain, Pain
- Trial name
- NCT01264887
- Testing
- Tapentadol Prolonged Release
- Where
- 12 sites in Bulgaria, Hungary and 5 more
- Volunteers
- 31 people
- Sponsor
- Grünenthal GmbH
Acute Ankle Sprain
Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain
This is a randomized, multi-center, double-blind, placebo-controlled, multi-dose, parallel-group study. Approximately 300 subjects (150 per group) 16 years of age and older with a current (within 24 hours from Visit 1) Grade I or…
- Trial name
- NCT01874626
- Testing
- SST-0225 Topical Ibuprofen Cream
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- Strategic Science & Technologies, LLC
Pain, Analgesics, Opioid
A Repeated Dose Study of the Metabolism and Action Evaluation of OROS Hydromorphone HCI (Slow Release) Tablets in Patients With Chronic Pain
The purpose of this study was to characterize the steady-state pharmacokinetic (metabolism and action) profile of OROS hydromorphone HCI (slow release) in patients who required opioid therapy on a daily basis for chronic pain…
- Trial name
- NCT00410878
- Testing
- OROS Hydromorphone HCI (slow release)
- Volunteers
- 22 people
- Sponsor
- Alza Corporation, DE, USA
Advanced Solid Cancers
Opioid Rotation Versus Combination for Chronic Uncontrolled Cancer Pain
For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered for anecdotal reasons.
- Trial name
- NCT00478101
- Testing
- oxycodone fentanyl
- Volunteers
- 2,006 people
- Sponsor
- Gachon University Gil Medical Center
Pain
Procedures of Locoregional Analgesia and Quality of Life in Palliative Care Units
Number of patients in mobile palliative care units have pain of both nociceptive and neuropathic origin. In certain cases, procedures of locoregional analgesia can be helpful.
- Trial name
- TALViSoP (NCT01094912)
- Testing
- opioids
- Where
- 6 sites in France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Limoges
Breast Cancer
A Randomized Controlled Trial (RCT) to Determine the Efficacy of a Multidisciplinary CBT Based Pain Management Program for the Treatment of Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS) in Breast Cancer Survivors
The purpose of this research is to evaluate the effectiveness of a multidisciplinary pain management program for AIMSS in reducing pain, subjective cognitive complaints, psychological distress, and impaired functional status…
- Trial name
- NCT06831838
- Testing
- Cognitive Behavioral Therapy based Pain Management Program
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Mayo Clinic
PCST-Full (Pain Coping Skills Training), PCST-Brief
Optimizing Delivery of a Behavioral Cancer Pain Intervention Using a SMART
This trial is a sequential multiple assignment randomized trial (SMART), that will examine response to differing doses of a behavioral cancer pain intervention (Pain Coping Skills Training [PCST]) and subsequent response-based…
- Trial name
- SMART (NCT02791646)
- Testing
- Pain Coping Skills Training Full, Pain Coping Skills Brief
- Where
- United States
- Volunteers
- 327 people
- Sponsor
- Duke University
Neoplasm Metastasis, Pain
Virtual Reality for Advanced Cancer Pain
Background Pain is commonly experienced by people who are living with advanced (incurable) cancer. There is evidence to suggest virtual reality could help to relieve this pain: however, this evidence is poor quality with the…
- Conditions
- Neoplasm Metastasis, Pain, Palliative Care
- Trial name
- VRcan (NCT06534580)
- Testing
- Virtual Reality
- Where
- 4 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Chronic Pain
Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain
The purpose of this study is to confirm effectiveness and safety of fentanyl transdermal patch Durogesic® D-Trans for treatment of chronic pain in participants with chronic non-cancer pain.
- Trial name
- NCT01902524
- Testing
- Fentanyl-TTS
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Janssen Korea, Ltd., Korea
Cancer Pain, Cancer
Treatment Efficacy of Mindfulness-based Cognitive Therapy for Distress in Advanced Cancer Patients
'Distress' refers to emotional distress, including psychological distress, in cancer patients. This study aims to explore whether mindfulness-based cognitive-behavioral therapy for cancer patients is effective in relieving…
- Conditions
- Cancer Pain, Cancer, Distress, Emotional, Therapy-Associated Cancer
- Trial name
- MBCT (NCT05768256)
- Testing
- Mindfulness-Based Cognitive-behavioral Therapy for Distress
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- CHA University
Interviews
Impact of a Pharmaceutical Interview at the Initiation of Opioid Treatment for Acute Non-cancer Pain
In adult emergency departments, the number of admissions for adverse effects related to opioid use is constantly increasing. However, the massive flow of patients, lack of time, and rapid rotation of physicians in this department…
- Trial name
- OPI-HOME (NCT07049796)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Upper Abdominal Cancer Pain, Pancreatic Cancer
Outcomes of Fluoroscopy-Guided Transdiscal Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain.
The goal of this prospective study is to learn whether fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal cancer pain in adults with pancreatic, gastric, or hepatobiliary cancer.
- Conditions
- Upper Abdominal Cancer Pain, Pancreatic Cancer, Gastric Cancer, Hepatobiliary Cancer
- Trial name
- NCT07825870
- Testing
- Chemical Neurolysis
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Sahiwal medical college sahiwal
Intractable Pain, Palliative Care
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
This study will examine the safety of giving the experimental drug, resiniferatoxin (RTX), to treat severe pain in patients with advanced cancer. RTX is a chemical extracted from a cactus-like plant.
- Trial name
- NCT00804154
- Testing
- Intrathecal Resiniferatoxin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Interactable Malignant Perineal Pain
Thermal Radiofrequency Versus Neurolytic Saddle Rhizotomyfor Severe Pereneal Cancer Pain
The control of perineal malignant pain is difficult and challenging for pain physicians. Different modalities have been tried to treat this complex pain syndrome including pharmacotherapy and interventional therapy.
- Trial name
- NCT03084575
- Testing
- Thermal radio Frequency, selective (unilateral S3, bilateral S4 and S5) saddle rhizotomy, hyperbaric chemical saddle Rhizotomy (6 % pherol in glycerin), Thermal RF lesioning is done using Bailys RF generator
- Volunteers
- 40 people
- Sponsor
- Cairo University
Breast Cancer, Arthralgia
Observational Study to Evaluate Mechanisms of Aromatase Inhibitor Associated Musculoskeletal Symptoms
Early stage hormone receptor positive breast cancer is typically treated with adjuvant endocrine therapy in order to decrease risk of breast cancer recurrence and to improve overall survival from the disease.
- Trial name
- NCT02118636
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Lynn Henry
Bone Metastasis, Oncology Pain
Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality
The goal of this clinical trial is to assess the impact of reducing the volume of palliative metastatic bone irradiation on analgesic effectiveness at day 30 and to evaluate the efficiency of telemonitoring in identifying…
- Trial name
- SPINAL (NCT06884332)
- Testing
- Sparing irradiation, Conventional spinal irradiation
- Where
- 4 sites in France
- Volunteers
- 598 people
- Sponsor
- Institut de Cancérologie de Lorraine
Pain, Advanced Cancer
Sativex® for Relieving Persistent Pain in Patients With Advanced Cancer
This 9-week study aimed to determine the efficacy, safety, and tolerability of nabiximols (Sativex®) as an adjunctive treatment, compared with placebo in relieving uncontrolled persistent chronic pain in participants with…
- Trial name
- SPRAY III (NCT01361607)
- Testing
- Nabiximols
- Where
- 68 sites in United States, Bulgaria and 8 more
- Volunteers
- 399 people
- Sponsor
- Jazz Pharmaceuticals
Chronic Pain, Musculoskeletal Diseases
Effectiveness of Coping Strategies on the Control of Chronic Non-Cancer Pain and Quality of Life (CNCP_CopQol)
Introduction and objectives: Non-pharmacological interventions in patients with musculoskeletal chronic non-cancer pain (mCNCP) are positioning themselves as an essential pillar in treatment along with pharmacological and…
- Conditions
- Chronic Pain, Musculoskeletal Diseases, Quality of Life, Pain Measurement
- Trial name
- CNCP_CopQol (NCT04696107)
- Testing
- Psychoeducative intervention
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Hospital San Juan de Dios del Aljarafe de Sevilla
Cancer Pain
3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain
This study aims to evaluate the safety and efficacy of 3D1002 alone or in combination with oxycodone hydrochloride sustained-release tablets (OxyContin) for the management of moderate or severe cancer pain.
- Trial name
- NCT05265052
- Testing
- 3D1002 (50 mg)(Phase IIa), 3D1002 (100 mg)(Phase IIa), 3D1002 (150 mg)(Phase IIa)
- Volunteers
- 177 people
- Sponsor
- 3D Medicines