Clinical trials: Cancer-Related Condition
NSCLC
Evaluation of the High Dose of Icotinib in Advanced Lung Cancer Patients After Failure of Target Therapy
The purpose of this study is to evaluate the efficacy and safety of dose escalation of Icotinib in advanced non small cell lung cancer (NSCLC) patients after the therapy of Icotinib, Iressa and Tarceva.
- Trial name
- NCT01963195
- Testing
- Icotinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Medical University
Malignancy, Immune System Diseases
Immuno-Oncology Database and Bioregistry
Immunotherapy, especially immune checkpoint inhibitors (ICIs), are effective in treating many different types of cancers. ICIs fight cancer by driving the immune system into an "activated state" that makes it harder for tumor…
- Conditions
- Malignancy, Immune System Diseases, Autoimmune Diseases
- Trial name
- IOG (NCT04656873)
- Testing
- Biospecimen Collection, Medical Chart Review, Questionnaires/Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Ultrasound and Chemotherapy of Breast Cancer: Relationship Between Early Vascular Changes of the Tumor and Late Tumoral Response
This study intends to assess the ability of contrast-enhanced ultrasound to make the efficacy of chemotherapy in breast cancer precise.
- Trial name
- NCT00245869
- Testing
- Contrast-enhanced Ultrasound
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Lymphoma
A Study of Brentuximab Vedotin in Adults With CD30-positive Lymphoma
Participants with CD30-positive lympoma will be treated with brentuximab vedotin according to their clinic's standard practice. The main aim of this study is to collect information on any side effects from treatment with…
- Trial name
- NCT04837222
- Testing
- No Intervention
- Where
- 32 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Takeda
Cancer-related Problem/Condition, Cancer-related Fatigue
Engagement and Acceptability of the Untire mHealth App
The aim of this study will be to assess the engagement and acceptability of the Untire mHealth intervention for adults with cancer related fatigue. Acceptability will be assessed after 2, 4, 6 and 12 weeks of app use.
- Trial name
- NCT05891431
- Testing
- Untire mobile app
- Where
- 2 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Bath
Blastomycosis
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or…
- Trial name
- NCT00001702
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Anastomotic Leakage
The Relationship Between Drainage Fluid and Anastomotic Leakage After Colorectal Cancer Surgery
A prospective and analytical study on the detection of early anastomotic leakage by abdominal drainage fluid after colorectal cancer surgery. pay attention to indicators including bilirubin
- Trial name
- NCT05191602
- Testing
- drainge fluid
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Southwest Hospital, China
Tobacco Use Disorder
Assessing the Variability Over Time of Tobacco Carcinogen Biomarkers in Smokers - 2
Lung cancer is the leading cause of cancer death in the United States. Currently it remains impossible to predict which smokers will get cancer. Each puff of a cigarette delivers a mixture of over 60 known carcinogens.
- Trial name
- NCT00158145
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Neoplasm Cervix
Topical Curcumin for HPV Related Cervical Disease
The purpose of this study is to see if curcumin can suppress HPV infection in women with low-grade squamous intraepithelial lesions (LSIL) disease or treated high-grade squamous intraepithelial lesions (HSIL) disease.
- Trial name
- NCT04266275
- Testing
- Curcumin C3 Complex
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Lisa Flowers
CIN 2/3, HPV Infection
Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)
This is a phase II double blind, placebo-controlled, randomized study of Artesunate vaginal inserts for the treatment of women who have cervical high grade intraepithelial neoplasia (CIN2/3).
- Conditions
- CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia
- Trial name
- ART-CIN_IIB (NCT04098744)
- Testing
- Artesunate vaginal insert
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Breast Cancer
Ethnic Differences in the Impact of Breast Cancer on Employment Status, Financial Situation, and Quality of Life
The purpose of this study is to learn more about how being treated for breast cancer affects patients' employment, financial situation, and quality of life on a short-term basis and on a long term basis.
- Trial name
- NCT01134172
- Testing
- survey web-based or telephone interview
- Where
- 12 sites in United States
- Volunteers
- 935 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Colorectal Cancer Metastatic
Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
Colorectal cancer (CRC) has the third highest cancer incidence in the world. There is mounting evidence that the intestinal microbiota plays an important role in colorectal carcinogenesis.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, Intestinal Parasite, Protozoan Infections
- Trial name
- NCT03173001
- Testing
- Parasitological examination
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction
Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction
RATIONALE: The use of endoscopy to place a metal stent in the large intestine is less invasive than surgery for treating cancer-related bowel obstruction and may have fewer side effects and improve recovery.
- Conditions
- Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction, Gastric Cancer, Gastrointestinal Carcinoid Tumor
- Trial name
- NCT00004911
- Testing
- bowel obstruction management, quality-of-life assessment
- Where
- United States
- Sponsor
- Northwestern University
Pleural Effusion, Malignant
Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion
The objective of this study is to analyze the correlation between pleural elastance and the radiological effectiveness (measured by chest tomography) of pleurodesis performed via catheters in patients with RMPE.
- Trial name
- NCT01819363
- Testing
- Pleural elastance
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Lymphoma, Leukemia
Reduced-intensity, Related-donor Bone Marrow Transplantation Followed by High-dose Cyclophosphamide for Hematologic Cancers
This research is being done to learn more about reduced-intensity bone marrow transplantation (BMT), also known as a "mini" transplant for patients with blood cancers, using bone marrow from a relative.
- Conditions
- Lymphoma, Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT01135329
- Testing
- Fludarabine, Busulfan, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Colon Cancer
Exploration of the Relationship Between Mismatch Repair Status of Colorectal Cancer and Lymph Node Metastasis Patterns and Pathological High-risk Factors
This study analyzed the differences in clinical baseline features and survival outcomes between pMMR and dMMR patients. The aim is to evaluate the impact of MMR status on overall survival and disease-free survival of colorectal…
- Trial name
- NCT06798857
- Volunteers
- 1,471 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Breast Cancer
Self-Care for Lymphedema in Patients With Breast Cancer
RATIONALE: Identifying why patients don't do self care for lymphedema may help doctors plan better at-home self-care treatment. PURPOSE: This research study is looking at self-care practices for lymphedema in patients with breast…
- Trial name
- NCT00670644
- Testing
- questionnaire administration, survey administration, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 51 people
- Sponsor
- Vanderbilt University
Chronic Pain, Opioid-use Disorder
Validation of the ASI-SR Form in a Population of Chronic Non-cancer Pain Patients
The Swedish version of ASI-SR has shown good feasibility in assessment of addiction patients functioning compare to long and time-consuming ASI, which is upp to date golden standard in Sweden.
- Conditions
- Chronic Pain, Opioid-use Disorder, Quality of Life, Risk Reduction
- Trial name
- ASI-SR (NCT04998734)
- Testing
- ASI-SR
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Uppsala University
Cancer, Chronic Pain
Cannabis Oil for Pain Effectiveness
This project represents a first systematic, prospective, single-arm cohort study of a safe and effective dosing regimen of an orally administered cannabis oil formulation in a cancer subject population with poorly controlled pain.
- Trial name
- COPE (NCT03522467)
- Testing
- MRCP001
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Aurora Cannabis Inc
Sarcoma, Unspecified Adult Solid Tumor, Protocol Specific
Liposomal Doxorubicin and PSC 833 in Treating Patients With AIDS-Related Kaposi's Sarcoma or Other Advanced Cancers
The rationale for conducting this study lies in the premise that if indeed the reason for a limited response of Kaposi's sarcoma lesions and other advanced malignancies to chemotherapy is attributable to a high expression of…
- Trial name
- NCT00003207
- Testing
- pegylated liposomal doxorubicin hydrochloride, PSC 833
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Washington University School of Medicine
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