Clinical trials: Cannabis Abuse
Cannabis, HIV Neuropathy
Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain
Acute cannabis administration is reported to alleviate HIV neuropathic pain (HIV-NP), but there is limited knowledge about the effects of cannabis constituents (delta-9 tetrahydrocannabinol/THC and cannabidiol/CBD), the…
- Conditions
- Cannabis, HIV Neuropathy, Pain Syndrome
- Trial name
- NCT03099005
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Marijuana Dependence
Effectiveness Study of Dronabinol and BRENDA for the Treatment of Cannabis Withdrawal
This treatment study is targeted specifically for those who want to stop using marijuana. We want to find out if patients who are dependent on marijuana and want to stop using are helped by a combination of the drug dronabinol…
- Trial name
- NCT00480441
- Testing
- Dronabinol, BRENDA therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Pennsylvania
Neoplasms Pancreatic, Cachexia; Cancer
The Effect of Cannabis in Pancreatic Cancer
Cannabinoids are known to increase appetite, but THC components have psychogenic properties too. CBD is the main component in the plant, and have only minimal psychogenic effects.
- Conditions
- Neoplasms Pancreatic, Cachexia; Cancer, Cannabis, Appetite Loss
- Trial name
- NCT03245658
- Testing
- THC and CBD Mixture
- Where
- Denmark
- Sponsor
- Jens Rikardt Andersen
Cannabis Dependence, Psychostimulant Dependence
Evaluation of the Effects of Treatment of Psycho-stimulant and Cannabis-dependent Users in Israel
This study evaluates the effects of psychological and pharmacological treatment of regular users of cannabis and psychostimulants in a treatment center (Kfar Izun) in Israel.
- Trial name
- NCT01510015
- Testing
- Risperidone
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Health, Subjective, Inflammatory Response
Efficacy and Safety of Hemp-derived, Full Spectrum Cannabigerol (CBG) in Adults
The goal of this observational study is to provide exploratory research into the in vivo physiological and psychological effects, if any, of cannabigerol (CBG) in healthy human adults age 21 or over.
- Conditions
- Health, Subjective, Inflammatory Response, Adverse Effect, Side Effect
- Trial name
- NCT05743985
- Testing
- Cannabigerol
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Formula30A LLC
Cannabis, Post Traumatic Stress Disorder
Nabilone in Cannabis Users With PTSD
Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown.
- Trial name
- NCT03251326
- Testing
- Nabilone, Cannabis, Propranolol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Traumatic Injury, Pain, Acute
Evaluation of Dronabinol For Acute Pain Following Traumatic Injury
Single center, non-blinded, randomized controlled trial. Enrollment is based on ≥50 MME within 24 hours of admission, followed by a 24 hour screening/randomization window and a participation period extending through the acute…
- Trial name
- NCT03928015
- Testing
- Adjunctive dronabinol, Systemic analgesics
- Where
- United States
- Sponsor
- CommonSpirit Health
Pain, Insomnia
Effect of Medical Marijuana on Neurocognition and Escalation of Use
This study will use a randomized controlled design to test whether patients who use medical marijuana, compared to a waitlist control group, experience a change in health outcomes (relief of symptoms, or adverse health outcomes…
- Conditions
- Pain, Insomnia, Depression, Anxiety
- Trial name
- MMNE (NCT03224468)
- Testing
- Medical Marijuana
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072560
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Psychosis, Cannabis Use
Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis
Canada reports some of the highest rates of cannabis use in our youth and young adult populations, among all the developed countries.
- Trial name
- NCT07001878
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Nova Scotia Health Authority
Cannabis
Delta-8-THC vs. Delta-9-THC on Simulated Driving Performance
Delta-8-THC is an isomer of delta-9-THC that has become widely available due to the legalization of hemp and its derivatives. Very little controlled research has been conducted with delta-8-THC and some research suggests it…
- Trial name
- NCT06218550
- Testing
- Delta-9-THC, Delta-8-THC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use Disorder, Cannabis Dependence, Continuous
Brain Imaging of Cannabinoid Receptors
All participants will be healthy volunteers and all procedures will be completed for research purposes only. Two groups will be recruited, females who use cannabis (marijuana, MJ), and female who do not use cannabis (controls).
- Trial name
- NCT03204305
- Testing
- 11C-OMAR, Cannabis
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis-Related Disorder, Substance-Related Disorders
First Episode Schizophrenia and Cannabis-Related Disorder Study
Many individuals with schizophrenia abuse cannabis at the onset of their illness, portending a poorer course of illness and poorer treatment response.
- Conditions
- Cannabis-Related Disorder, Substance-Related Disorders, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00573287
- Testing
- clozapine, risperidone
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Opioid Use Disorder, Cannabis Use
Cannabis Effects on Opioid Self-Administration
The study will enroll participants with opioid use disorder and participants will reside at the University of Kentucky Hospital for this 6-week inpatient trial.
- Trial name
- NCT07668635
- Testing
- Cannabis, Intranasal Opioid Agonist, Oral Opioid Agonist
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shanna Babalonis, PhD
Cannabis
A Study of Ingested Cannabidiol in Healthy Occasional Cannabis Users
The purposes of this study are 1) to determine if the administration of different low doses of oral CBD (20 mg, 50 mg, 100 mg and 200 mg) result in detectable subjective pleasant drug effect compared to placebo and 2) to…
- Trial name
- NCT05407285
- Testing
- Cannabis 20 mg,, Cannabis 50 mg, Cannabis 100 mg
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cannabis
Internet-Based Treatment for Individuals With Regular Cannabis Use: A Randomized Controlled Trial
The aim of this randomized controlled trial is to investigate the effects of a Swedish Internet-based treatment program for individuals from the general population with a regular cannabis use.
- Trial name
- NCT02408640
- Testing
- Cannabishjalpen.se
- Where
- Sweden
- Volunteers
- 303 people
- Sponsor
- Karolinska Institutet
Cannabis Use, Driving Impaired
Neural Correlates of Driving and Cannabis
Driving is a set of complex tasks and requires use of multiple cognitive domains, including attention, planning, and memory. In laboratory studies, the main psychoactive component in cannabis, delta-9-tetrahydrocannabinol (THC)…
- Trial name
- NCT03581058
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Unity Health Toronto
Cannabis-use Disorders
Behavioral Effects of Pregabalin and Cannabis
Cannabis is the most commonly used illicit drug in the United States, and its use is associated with rates of development of abuse and dependence, treatment admission and relapse that are comparable to other illicit drugs.
- Trial name
- NCT01511640
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cannabis Use Disorder
Cannabidiol (CBD) for the Management of Cannabis Withdrawal: A Phase II Proof of Concept Study
Single subject repeated measures design of an open label administration of Cannabidiol (CBD) to 5 participants withdrawing from cannabis use in an inpatient setting.
- Trial name
- NCT02083874
- Testing
- CBD
- Volunteers
- 5 people
- Sponsor
- The University of New South Wales
Schizophrenia
Impact of Cannabis Consumption on Psychotic Symptoms and Reality Monitoring in Patients With Schizophrenia: a Real-life Study
This study aims to examine the dual effects of cannabis consumption on both positive and negative symptoms of schizophrenia, across laboratory and real-world contexts.
- Trial name
- F_r_IEND-3 (NCT07309159)
- Testing
- Ecological Momentary Assessment (EMA) and Reality Monitoring tasks
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux