Clinical trials: Cardiac
Anxiety, Chest Tube Removal
Virtual Reality-Based Breathing Yoga Before Chest Tube Removal After Cardiac Surgery
This randomized controlled trial was conducted to evaluate the effect of virtual reality-based breathing yoga applied before chest tube removal on pain and anxiety in patients after cardiac surgery.
- Conditions
- Anxiety, Chest Tube Removal, Pain After Surgery
- Trial name
- NCT07794709
- Testing
- Virtual Reality-Based Breathing Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sennur Kula Şahin
Cardiac Arrhythmia, Syncope
Comparative Study of the Sternal Patch System With a Conventional Holter Recorder
This study will be a comparison of two externally worn recording systems for documentation of cardiac arrhythmias in symptomatic patients or patients at risk for arrhythmia.
- Trial name
- NCT04241692
- Testing
- CarnationTM Ambulatory Monitoring Sternal ECG Patch System, Conventional 24-Hour 7 Lead Holter Monitor Recorder
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Cardiac Resynchronization Therapy, Magnetic Resonance Imaging (MRI)
MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)
The goals of this project are to: 1) explore the potential use of magnetic resonance imaging (MRI) data for improved prediction of response to cardiac resynchronization (CRT), and 2) use the MRI-derived data together with a…
- Trial name
- NCT02728336
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Fever, Heart Rate, Fetal (FHR)
Acetaminophen for Fetal Tachycardia: a Randomized Pilot Trial
The most common cause of fetal tachycardia is maternal fever. Fetal tachycardia often precedes the maternal fever, and fetal tachycardia confounds the interpretation of electronic fetal monitoring (EFM), increasing the rate of…
- Trial name
- NCT00377832
- Testing
- Acetaminophen 975 mg
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Heart Failure, Pulmonary Hypertension
Development of Novel Physiological CMR Methods in Health and Disease
Physiological cardiovascular stress test plays a crucial role in the assessment of patients with suspected heart disease. There are several methods of cardiac physiological stress tests and each of them offer varied insight into…
- Conditions
- Heart Failure, Pulmonary Hypertension, Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT03854071
- Testing
- intravenous fluid challenge
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Heart Transplantation, Elevated Resting Heart Rate
An Interventional Study to Evaluate the Effect of Ivabradine on Exercise Capacity in Heart Transplant Recipients
The hypothesis is that the treatment with ivabradine will increase pVO2 after 16 weeks of treatment compared to baseline in the heart transplant recipient population with elevated resting HR.
- Trial name
- NCT03619187
- Testing
- Ivabradine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Amgen
Healthy Subjects
A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects
The purpose of this study is to demonstrate a lack of effect of venlafaxine (Effexor XR) on QTc intervals relative to time matched placebo in healthy volunteers
- Trial name
- NCT02637193
- Testing
- Venlafaxine, Moxifloxacin
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB
Turner Syndrome, Infertility, Female
Turner Syndrome Minipuberty Study
Rationale: Due to accelerated germ cell loss, infertility is a major problem in girls with Turner syndrome (TS). Therefore, cryopreservation of ovarian tissue or oocytes before exhaustion of the ovarian reserve may preserve…
- Conditions
- Turner Syndrome, Infertility, Female, Premature Ovarian Failure, Gonadal Dysgenesis
- Trial name
- Minipuberty (NCT04189406)
- Testing
- Venapunction
- Where
- 13 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Assess the Relation Between Glycemic Gab and Adverse Clinical Outcomes in Diabetic Patients Who Hospitalized With Heart Failure
Glycemic Gap Versus Admission Plasma Glucose Level As Predictors of ICU Out Comes in Type 2 Diabetic Patients With Acute Heart Failure
assess the relation between glycemic gab and adverse clinical outcomes in diabetic patients who hospitalized with heart failure
- Trial name
- NCT04922099
- Testing
- glycemic gap
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Assiut University
Blood Pressure, Heart Rate Variability
The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia.
- Trial name
- NCT00809432
- Testing
- Face mask (Dust Respirator), No Face mask
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Laminopathy, Lamin A/C Gene Mutation
Subanalysis in Patients With CARDIoLAMinopathy Enrolled to REPORT-CCM Registry
Observational, retrospective registry with acute and chronic endpoints
- Conditions
- Laminopathy, Lamin A/C Gene Mutation, Heart Failure
- Trial name
- CARDILAM-CCM (NCT04904393)
- Testing
- Implant of the device for Cardiac Contractility Modulation (CCM) Therapy
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Monaldi Hospital
CORONARY ARTERY DISEASE
Multisensor Array for the Localisation of Coronary Artery Stenosis (MALCAS)
This is a proof of concept study involving a novel medical device, developed to investigate the potential for detecting and localising coronary artery stenosis.
- Trial name
- MALCAS (NCT04647448)
- Testing
- Application of sensor patch
- Volunteers
- healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Cardiac Diseases
The Effect of Perioperative Medications on the Outcomes of Patients Undergoing Cardiac Surgery
This study will be a retrospective study. The patient data from the electronic medical records and existing database will be collected and analyzed.
- Trial name
- NCT01683448
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Congenital Heart Disease
Genetics of Congenital Heart Disease
Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown.
- Trial name
- NCT01192048
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Chest Pain
Validation of the Siemens System Somatom Definition and Operating Software for Cardiac CT Studies
We are evaluating a new computer software package to help us acquire and interpret heart CT studies, which is the purpose of this research project.
- Trial name
- SOMARIS (NCT00481468)
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Cardiac Arrest
Improving Defibrillation Pad Position
Manufacturer's diagrams showing defibrillation pad positioning (as used on public access defibrillators) are anatomically incorrect and are likely to lead to poor position of defibrillation pads, with reduced defibrillation…
- Trial name
- NCT03476720
- Testing
- Pad positioning according to a manufacturer's diagram
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Heart Failure, Aortic Stenosis
The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis
The role of cardiac mechanics, circulating biomarkers and frailty in predicting outcomes in patients with aortic stenosis after aortic valve replacement (SCRABLES -The 2-Parts Study) Part I: Observational study to characterize…
- Trial name
- SCRABLES (NCT02856620)
- Testing
- Observational only
- Where
- Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Christine Henri
Anxiety Depression
Influence of Oral Probiotics on Anxiety and Depression in Adolescents After Non-cardiac and Non-gastrointestinal Surgeries: A Prospective, Double-blind, Placebo-controlled Study
This study intends to conduct a prospective, double-blind, randomized, controlled trial. Adolescents aged 12-17 years old and American Society of Anesthesiologists (ASA) physical status I and II are selected as subjects.
- Trial name
- NCT07640490
- Testing
- C Group, P Group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Erectile Dysfunction, Coronary Artery Disease
Erectile and Ejaculatory Function Following Coronary Revascularization
This observational, cross-sectional study aims to compare erectile and ejaculatory function between men with a history of coronary revascularization and men without known coronary artery disease.
- Conditions
- Erectile Dysfunction, Coronary Artery Disease, Ejaculation Disorders
- Trial name
- NCT07878260
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
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