Clinical trials: Cardiac Arrest, active
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
The Danish Out-of-Hospital Cardiac Arrest Study
After resuscitation from Out-of-Hospital Cardiac Arrest (OHCA) patients experience Post Cardiac Arrest Syndrome due to ischemia and reperfusion injury.
- Trial name
- DANOHCA (NCT05895838)
- Testing
- Dexamethasone, Backrest elevation, Early wakeup call
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Christian Hassager
Cardiac Arrest (CA), Cardiogenic Shock
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder
- Trial name
- VentilO CU (NCT07484828)
- Testing
- Initiation of mechanical ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Cardiac Arrest (CA), Carotid Doppler
CAROTID DOPPLER AND CEREBRAL OXIMERY IN POST CARDIAC ARREST ICU PATIENTS
Out-of-hospital cardiac arrest (OHCA) is one of the most critical conditions in emergency medicine, causing high mortality and severe neurological sequelae due to the sudden cessation of circulation.
- Trial name
- NCT07918391
- Testing
- Carotid Doppler Ultrasonography, Transcranial Doppler, Optic Nerve Sheath Diameter Measurement, and Cerebral Oximetry
- Volunteers
- 28 people
- Sponsor
- Inonu University
Cardiac Arrest
Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds…
- Trial name
- AfterROSC2 (NCT05606809)
- Testing
- Calculation of early prognosis score
- Where
- 5 sites in France
- Volunteers
- 4,500 people
- Sponsor
- AfterROSC
Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
Compression-Only Versus Standard Basic Life Support Training in Nursing Students
Survival after out-of-hospital cardiac arrest rarely exceeds 10%, and cardiopulmonary resuscitation (CPR) started by bystanders is a key factor for survival.
- Trial name
- NCT07915778
- Testing
- BLS and AED Training With Rescue Breaths, BLS and AED Training Without Rescue Breaths
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage
Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU
The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Cardiac Arrest (CA)
- Trial name
- SMART-CMD (NCT07917728)
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 240 people
- Sponsor
- Columbia University
Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest
Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse
FLECAPRO is a randomized controlled crossover trial assessing the effect and safety of adding flecainide to standard beta-blocker therapy to reduce the burden of ventricular arrhythmias in patients with arrhythmic mitral valve…
- Trial name
- FLECAPRO (NCT05631730)
- Testing
- Flecainide, Metoprolol
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Post-cardiac Arrest Brain Injury
Continuous Noninvasive Multimodal Neuromonitoring at the ICU After Cardiac Arrest
The goal of this observational study is to investigate the relationship between non-invasive brain monitoring measurements and neurological recovery six months after cardiac arrest in patients admitted to the intensive care unit…
- Trial name
- NCT07912411
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
Out-of-hospital Cardiac Arrest (OHCA)
Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) remains a major global public health challenge. Despite continuous advancements in resuscitation strategies, overall survival rates remain low.
- Trial name
- EXECT-CPR-2 (NCT07909642)
- Testing
- Transesophageal Echocardiography-Guided Chest Compression, Conventional Cardiopulmonary Resuscitation
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Far Eastern Memorial Hospital
Cardiac Arrest
Accuracy of Doppler Ultrasound Versus Manual Palpation of Pulse in Cardiac Arrest
The FloPatch FP120 device is indicated for use for the noninvasive assessment of blood flow in the carotid artery. The FloPatch FP120 device uses ultrasound and the Doppler effect to non-invasively assess the flow of flood.
- Trial name
- NCT05558228
- Testing
- FloPatch FP120
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Northwell Health
Cardiac Arrest, Out-Of-Hospital
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
The goal of this clinical trial is to learn if applying positive end-expiratory pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves neurological outcome in adults with out-of-hospital cardiac arrest who receive an…
- Trial name
- REVIVE-PEEP (NCT07905482)
- Testing
- Fixed PEEP Valve
- Where
- 3 sites in Netherlands
- Volunteers
- 3,200 people
- Sponsor
- Jeroen van Eijk
Cardiac Arrest
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
RACE-CARS is a real-world cluster-randomized trial designed to evaluate a multifaceted community and health systems intervention aimed to improve outcomes of out-of-hospital cardiac arrest.
- Trial name
- NCT04660526
- Testing
- Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use.
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Duke University
Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR)
The OXY-VENT Study
Effective ventilation during cardiopulmonary resuscitation is essential but can be difficult to achieve consistently. Current practice relies on visible chest rise to guide ventilation volume, although this may not always…
- Trial name
- OXY-VENT (NCT07870551)
- Testing
- Ventilation Feedback Device (Active), Control (Recording-Only)
- Where
- Netherlands
- Volunteers
- 515 people
- Sponsor
- Jeroen van Eijk
Cardiac Arrest, Out-Of-Hospital, Hypotension
Cardiac Arrest - Ultrasound Detection of Occult Perfusion
The goal of this study is to describe the population of patients presenting after out of hospital cardiac arrest with occult perfusion, defined as a patient without a palpable pulse but with some evidence of pulsatile arterial…
- Trial name
- NCT07897370
- Where
- 8 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- University of Massachusetts, Worcester
Cardiac Arrest, Cardiopulmonary Resuscitation
Generative AI and Gamified Simulation-Based Train-the-Trainer Basic Life Support Training for High School Teachers in Vietnam
The goal of this randomized controlled trial is to learn whether adding generative artificial intelligence (AI) feedback, gamified practice and a structured Train-the-Trainer component to a one-day simulation-based Basic Life…
- Trial name
- NCT07898891
- Testing
- Generative AI and Gamified Simulation-Based Train-the-Trainer BLS Programme, Conventional Instructor-Led Simulation-Based BLS Training
- Where
- 2 sites in Thailand, Vietnam
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Eastern International University
Survival to Discharge With Good Neurologic Outcome Among in Hospital Cardiac Arrest Patients
Therapeutic Outcomes of In-Hospital Resuscitation of Patients Admitted to the Internal Medicine Wards
In-hospital cardiac arrest is a common phenomenon associated with high mortality rates. In the United States, 290,000 cases of in-hospital cardiac arrest among adult patients occur annually (1).
- Trial name
- NCT07899645
- Volunteers
- 2,000 people
- Sponsor
- Meir Medical Center
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Cardiac Arrest
Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns
Newborn infants who require cardiopulmonary resuscitation at birth receive chest compression using a 3-Compression to 1-Ventilation (3:1 C:V) ratio.
- Trial name
- SUR1VE-2 (NCT06577818)
- Testing
- CC+SI (Chest compression during sustained inflation), 3:1 C:V (3:1 Compression:Ventilation ratio)
- Where
- Canada
- Volunteers
- 554 people
- Sponsor
- University of Alberta
Cardiac Arrest (CA)
The VENTOR Clinical Study
To evaluate the initial safety and effectiveness of the Ventor Airway System in providing short-term ventilation support in non-breathing subjects during cardiopulmonary resuscitation (CPR) and respiratory arrests.
- Trial name
- VENTOR (NCT06759389)
- Testing
- Resuscitation (Ventor)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- CoLabs Medical
Cardiac Arrest (CA)
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital…
- Trial name
- PEDICA (NCT07890610)
- Where
- 22 sites in United States
- Volunteers
- 1,620 people
- Sponsor
- Children's Hospital of Philadelphia