Clinical trials: Cardiac Autonomic Function
Autonomic Nervous System Diseases
HUTT to Assess Cardiac Autonomic Nervous Function
Autonomic nervous system diseases can cause abnormalities in the circulatory system, leading to malignant arrhythmia and sudden cardiac death.
- Trial name
- NCT06236945
- Where
- China
- Volunteers
- 1,122 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Hebei Medical University
Type 1 Diabetes Mellitus
To Evaluate if Wide Blood Sugar Fluctuations Lead to Injury of Heart Function and Heart Nerves
This proposal will test if, in patients with type 1 diabetes, wide blood glucose fluctuations lead to the injury to heart nerves , called cardiac autonomic neuropathy (CAN), and to impaired heart contractile (pumping) function…
- Trial name
- NCT01170832
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Phototherapy, Autonomic Nervous System
Effects of Phototherapy Associated With Sprint and Squat Training on Cardiac Autonomic Modulation
Recent studies have shown positive results in the application of phototherapy for the improvement of performance and acceleration of the healing process of the body homeostasis.
- Conditions
- Phototherapy, Autonomic Nervous System, Training
- Trial name
- NCT03566186
- Testing
- Phototherapy, Passive recovery
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Paulista University
Fatigue; Muscle, Heart, Fatigue, Mental
Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior
The goal of this randomized placebo controlled crossover trial is to determine effects of oral nicotine and caffeine pouches on anaerobic performance, autonomic function, cognition, and behavior in adult non-obese adult male…
- Trial name
- NCT06529055
- Testing
- Oral Pouch - Nicotine, Oral Pouch - Caffeine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Diabetes Mellitus Type 2, Heart Failure
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with…
- Conditions
- Diabetes Mellitus Type 2, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT06774014
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Caffeine, Exercise
7-Day Caffeine and Upper-Body Power in Active Women
This study investigated the effects of a 7-day caffeine supplementation on heart rate variability, cognitive performance, and upper-body anaerobic power in active women.
- Conditions
- Caffeine, Exercise, Physical Fitness
- Trial name
- NCT07771556
- Testing
- Caffeine
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV)
taVNS During Multi-site HRV Measurement: Reliability & Agreement Study
This study examines the reliability and agreement of autonomic nervous system measurements obtained from different anatomical sites during transcutaneous auricular vagus nerve stimulation (taVNS).
- Conditions
- Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV), Blood Pressure Monitoring, Transcutaneous Electric Nerve Stimulation
- Trial name
- taVNS-HRV (NCT07548723)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Atrial Fibrillation
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
The fMRI study is a prospective study with the objective of evaluating the effects of the autonomic central nervous system on the regulation of heart rate in patients with atrial fibrillation (AF).
- Trial name
- fMRI (NCT02524028)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Physiology of Manipulation / Mobilization in Healthy Adults
A Study of the Effects of Mid-Thoracic Spinal Manipulation and Spinal Mobilization on Heart Rate Variability
Spinal mobilization and spinal manipulation are common techniques utilized in the field of physical therapy. Despite their common utility, little is known about the physiological mechanisms underlying the changes experienced…
- Trial name
- NCT02380599
- Testing
- Spinal Manipulation, Spinal Mobilization
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mount St. Mary's College, Los Angeles, CA
Pain
The Effects of Pain and the Memory of Pain on Autonomic and Neuromuscular Function
The prevalence of chronic pain has been estimated at 30% in the US and these values may under report the true prevalence of people who experience long term pain as additional research has shown that 73% will have a reoccurrence…
- Trial name
- NCT02269384
- Testing
- Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mount St. Mary's College, Los Angeles, CA
Sudden Cardiac Death, Implantable Defibrillator User
Implantable Cardioverter Defibrillators - Improving Risk Stratification
Worldwide three million people a year die from sudden cardiac death (SCD). In most cases there is no warning and the heart is stopped by a sudden arrhythmia.
- Conditions
- Sudden Cardiac Death, Implantable Defibrillator User, Myocardial Infarction, Arrhythmias, Cardiac
- Trial name
- ICD-IRS (NCT01944514)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Atrial Fibrillation
Effects of Exercise Training in Patients With Permanent Atrial Fibrillation
Atrial fibrillation (AF) is a common arrhythmia. The proposed patholophysiological mechanisms of AF include abnormal electrical conduction in atrium and sympathovagal imbalance with increased vagal tone.
- Trial name
- NCT01721863
- Testing
- Exercise training
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypoxia, Altitude
Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects.
Exposure of healthy subjects to high altitude hypoxia elicits changes in cardiovascular, respiratory and metabolic features as weel as in exercise performance similar, for some aspects, to those observed in chronic heart failure.
- Conditions
- Hypoxia, Altitude, Heart Failure
- Trial name
- NCT00924833
- Testing
- Carvedilol, Nebivolol
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Autonomic Nervous System Diseases, Baroreflex Failure
Effects of Water and Glucose Drinks on Cardiovascular Function in Subjects With and Without Postprandial Hypotension
To determine whether the changes in blood pressure (BP) which occur following meals in normal people and patients who have substantial falls in BP after a meal postprandial hypotension (PPH)) are associated with changes in…
- Conditions
- Autonomic Nervous System Diseases, Baroreflex Failure, Blood Pressure, Hypotension
- Trial name
- NCT02713412
- Testing
- Glucose, Water
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Pain Perception, Autonomic Nervous System Functioning
Music-based Intervention for the Reduction of Pain
This study aims to compare the impact of listening to frequency-modulated music vs. non-modulated music (both researcher-selected), and to test whether there are differential effects on pain and stress perception.
- Trial name
- MINTREP (NCT02991014)
- Testing
- researcher-selected frequency-modulated music, researcher-selected non-modulated music, participant-selected non-modulated music
- Where
- 2 sites in Austria, Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Spinal Cord Injuries, Cardiovascular Abnormalities
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls…
- Conditions
- Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
- Trial name
- NCT05542238
- Testing
- One bout of moderate-intensity sub-maximal aerobic exercise
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Cryotherapy Effect
The Effects of Cold Water Immersion With Different Dosages (Duration and Temperature Variations) on Heart Rate Variability Post-exercise Recovery
The aim of the present study was to investigate the effects of cold water immersion (CWI) during post-exercise recovery with different durations and temperatures on heart rate variability (HRV) indices.
- Trial name
- NCT02499640
- Testing
- immersion cold water
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Paulista University
Stroke
The Autonomic Nervous System State and Response to Different Stimuli Among Patients Post Stroke: A Follow-up Study
The study describes the autonomic control system function in subjects post stroke in comparison with healthy subjects. Aims: To describe the Autonomic hart rate control system function in post stroke subjects in different…
- Trial name
- NCT01632410
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center